Zobrazeno 1 - 10
of 93
pro vyhledávání: '"J P, Hieble"'
Autor:
D. Gorny, B. Darblade, D. Brooks, J.-P. Hieble, F. Giuliano, Laurent Alexandre, G. Benoit, D. Behr-Roussel, Thierry Lebret
Publikováno v:
World Journal of Urology. 23:147-151
The aim of this study is to evaluate the potency of piboserod (SB 207266), a selective 5-HT(4) receptor antagonist, at inhibiting the 5-HT(4)-mediated potentiating effect of serotonin (5-HT) on the neurally-mediated contractile responses of human det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd82b859080f816f4ec12ebac3d7c55a
https://doi.org/10.1007/s00345-005-0499-z
https://doi.org/10.1007/s00345-005-0499-z
Publikováno v:
Pharmacology. 55:18-24
Molecular modeling studies have predicted that the beta-hydroxyl group of the catecholamines interacts with the beta 2-adrenoceptor at the serine residue at position 165 (Ser165) located on transmembrane helix IV; however, this has not been confirmed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97b8ae5bc68a3fd4b9f2a4f105cd74b0
https://doi.org/10.1159/000139508
https://doi.org/10.1159/000139508
Publikováno v:
Archiv der Pharmazie. 329:125-132
Vinylogous (Groups III and V) and acetylenologous (Group IV) analogs of the classical β-adrenergic agents - stimulant and blockers - were prepared in order to evaluate the effect of degree of saturation, position of unsaturation and rigidity of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::730bf4f56b477fb8eb766facca9b8b01
https://doi.org/10.1002/ardp.19963290304
https://doi.org/10.1002/ardp.19963290304
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 73:533-543
Adrenoceptors can be subdivided into three major types, the α1-, α2-, and β-adrenoceptors. Each of these types can be further subdivided into three subtypes, based on pharmacological characteristics. Molecular cloning techniques have supported thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84cf09c50ccce4333b3e094bac37c684
https://doi.org/10.1139/y95-068
https://doi.org/10.1139/y95-068
Publikováno v:
European Journal of Medicinal Chemistry. 28:251-257
A series of 2-amino-1,2,3,4-tetrahydro-1,4-epoxynaphthalenes were synthesized and tested for affinity for dopaminergic and α-adrenergic receptor subtypes via radioligand binding assays. The unsubstituted analogue 2a showed weak affinity for both D 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb7338dbc0872630d18650c09bd162ad
https://doi.org/10.1016/0223-5234(93)90141-z
https://doi.org/10.1016/0223-5234(93)90141-z
Publikováno v:
ChemInform. 24
A series of 2-amino-1,2,3,4-tetrahydro-1,4-epoxynaphthalenes were synthesized and tested for affinity for dopaminergic and α-adrenergic receptor subtypes via radioligand binding assays. The unsubstituted analogue 2a showed weak affinity for both D 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c703e565f234fda7c0c84756c5b6730
https://doi.org/10.1002/chin.199336166
https://doi.org/10.1002/chin.199336166
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23ddb1958bb9622678196e9ede1c633e
https://doi.org/10.1002/chin.199628115
https://doi.org/10.1002/chin.199628115
Autor:
R. R. Ruffolo, J. P. Hieble
Publikováno v:
Fundamental & Clinical Pharmacology. 6:7s-13s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14c6abb6ec9862718186d6daefae6ec9
https://doi.org/10.1111/j.1472-8206.1992.tb00136.x
https://doi.org/10.1111/j.1472-8206.1992.tb00136.x
Autor:
J P, Hieble
Publikováno v:
Current opinion in drug discoverydevelopment. 3(4)
Many important drugs act via the activation or blockade of adrenergic receptors. Although research has been ongoing in this area for over fifty years, the continual subdivision of the major adrenoceptor classes has provided new opportunities for drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::39b7cc1b28ceb64e200de944e8d7566e
https://pubmed.ncbi.nlm.nih.gov/19649869
https://pubmed.ncbi.nlm.nih.gov/19649869