Zobrazeno 1 - 10
of 71
pro vyhledávání: '"J P, Herault"'
Autor:
Nathalie Alet, Philippe Valet, Françoise Bono, Catherine Muller, J.-P. Herault, Cédric Dray, Paul J. Schaeffer, L. Millet, N. Delesque-Touchard, Isabelle Castan-Laurell, P. Savi, Oksana Kunduzova
Publikováno v:
FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2008, 22 (12), pp.4146-53. ⟨10.1096/fj.07-104018⟩
FASEB Journal, 2008, 22 (12), pp.4146-53. ⟨10.1096/fj.07-104018⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2008, 22 (12), pp.4146-53. ⟨10.1096/fj.07-104018⟩
FASEB Journal, 2008, 22 (12), pp.4146-53. ⟨10.1096/fj.07-104018⟩
International audience; Adipose tissue is an active endocrine organ that produces a variety of secretory factors involved in the initiation of angiogenic processes. The bioactive peptide apelin is the endogenous ligand of the G protein-coupled recept
Publikováno v:
Journal of Thrombosis and Haemostasis. 1:1959-1965
Factor (F)Xa and thrombin bound to the clot during its formation contribute to the propensity of thrombi to activate the coagulation system. The aim of this work was to study the inhibition of clot-bound FXa and clot-bound thrombin by SanOrg123781A,
Autor:
A Bernat, D.G. Meuleman, C. A. A. Van Boeckel, J.M. Herbert, J. P. Herault, M Petitou, J.C. Lormeau, Peter R. Hoffmann, van Rgm Amsterdam
Publikováno v:
Blood : the Journal of Hematology, 91(11), 4179-4205. American Society of Hematology
SANORG 34006 is a new sulfated pentasaccharide obtained by chemical synthesis. It is an analog of the “synthetic pentasaccharide” (SR 90107/ ORG 31540) which represents the antithrombin (AT) binding site of heparin. SANORG 34006 showed a higher a
Autor:
Jean-Marc Herbert, F. Dol, C. Avril, Françoise Bono, J.-P. Herault, Paul Schaeffer, A.M. Mares
Publikováno v:
Journal of Clinical Investigation. 101:993-1000
The binding of 125I-factor Xa to human aortic smooth muscle cell (SMC) monolayers was studied. At 4 degreesC, 125I-factor Xa bound to a single class of binding sites with a dissociation constant value of 3.6+/-0.7 nM and a binding site density of 11,
Publikováno v:
Blood Coagulation & Fibrinolysis. 8:161-167
The 'synthetic pentasaccharide', SR 90107A/Org 31540 (SP) representing the minimal AT-binding sequence of heparin is a catalyst of factor Xa inhibition. Affinity of SP, Sanorg 32701 (32701) and SR 80027 (80027), two close analogues of SP for rat, rab
Publikováno v:
Blood Coagulation & Fibrinolysis. 8:175-184
This study was done to document further the mechanism of the antithrombotic effect of CY 216 after subcutaneous injection in the rabbit. We first measured the circulating anti-factor Xa and anti-thrombin activities expressed in either International U
Autor:
J C Lormeau, J P Herault
Publikováno v:
Thrombosis and Haemostasis. 74:1474-1477
SummaryThe inhibition of thrombin generation (TG) was studied in plasma from human volunteers after single subcutaneous administrations of 4000, 8000 or 12,000 anti-Xa units (i.e., 6, 12 or 18 mg) of the synthetic pentasaccharide (SR 90107/ORG 31540)
Publikováno v:
Journal de Physique III. 1:389-414
Autor:
S K, Das, J M, Mallet, J, Esnault, P A, Driguez, P, Duchaussoy, P, Sizun, J P, Herault, J M, Herbert, M, Petitou, P, Sinaÿ
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 7(22)
We have used organic synthesis to understand the role of L-iduronic acid conformational flexibility in the activation of antithrombin by heparin. Among known synthetic analogues of the genuine pentasaccharidic sequence representing the antithrombin b
Publikováno v:
Thrombosis and haemostasis. 79(2)
The effect of SR121566A, a new non-peptide GP IIb-IIIa antagonist was studied in vitro with regard to thrombin generation in platelet rich plasma and in vivo on stasis-induced venous thrombosis in the rabbit. SR121566A inhibited ADP-, arachidonic aci