Zobrazeno 1 - 10
of 261
pro vyhledávání: '"J P, Hénichart"'
Publikováno v:
Prostaglandins, Leukotrienes and Essential Fatty Acids. 73:411-417
The arachidonic acid metabolizing enzymes, the cyclooxygenases (COXs) and lipoxygenases (LOXs), have been implicated in the development of a variety of cancers and numerous new therapeutic inhibitors are currently under investigation. However, given
Autor:
N. Pommery, J.-P. Hénichart
Publikováno v:
Annales Pharmaceutiques Françaises. 63:69-75
Because of the unavailability of effective therapies to block or reverse the progression of androgen-independent prostate cancer, it seems obvious to target growth signaling pathways for which frequently recurring mutations have been identified. Acqu
Autor:
N, Pommery, J-P, Hénichart
Publikováno v:
Annales pharmaceutiques francaises. 63(1)
Because of the unavailability of effective therapies to block or reverse the progression of androgen-independent prostate cancer, it seems obvious to target growth signaling pathways for which frequently recurring mutations have been identified. Acqu
Autor:
R, Millet, L, Goossens, J F, Goossens, P, Chavatte, K, Bertrand-Caumont, R, Houssin, J P, Hénichart
Publikováno v:
Journal of peptide science : an official publication of the European Peptide Society. 7(6)
Chemical modifications of dual NK1/NK2 ligand Cbz-Gly-Leu-Trp-OBzl(CF3)2 (1) enabled us to create a high NK1 selective ligand Cbz-Pro-Leu-Trp-OBzl(CF3)2 (2). A determination of the conformational behavior of tripeptide 2 in solution is described. The
Publikováno v:
Anti-cancer drug design. 13(8)
The mitogenic action of EGF is mediated by ligand-induced autophosphorylation of the EGF receptor (EGF-R), which is commonly overexpressed in numerous human cancers. Inhibitors of receptor tyrosine kinase (RTK) activity could therefore be considered
Publikováno v:
Anti-cancer drug design. 12(6)
A combilexin molecule containing two netropsin moieties attached to the aminoalkyl side chains of mitoxantrone has been synthesized and evaluated for cytotoxic activity towards murine L1210 leukaemia and human MCF7 carcinoma cells in vitro. It is mar
Publikováno v:
Peptide research. 9(6)
Five peptides related to the N-terminal sequence of the vasoactive intestinal peptide (VIP) have been synthesized. Two-dimensional nuclear magnetic resonance (2D-NMR) experiments (i.e., correlated spectroscopy [COSY]) and low temperature coefficient
Autor:
E, Differding, M, Gillard, N, Moguilevsky, F, Varsalona, M, Noyer, J, Daliers, S, Goldstein, M, Neuwels, M A, Lassoie, J P, Guillaume, M, Bascour, A, Bollen, J P, Hénichart
Publikováno v:
Journal de pharmacie de Belgique. 51(3)
The binding cavity of histamine and histamine antagonists is explored using site directed mutagenesis of the human histamine H1 receptor and the amino acids involved in ligand binding are identified. Whereas Asp107 and Phe199 are important for both a
Publikováno v:
Peptide research. 9(1)
Three different peptides, A13, A14x2 and A20, related to the Arc repressor from Salmonella phage P22, were synthesized. They all contained the 13 N-terminal residues of Arc known to form a beta-sheet interacting with the operator OArc. In the case of
Publikováno v:
Anti-cancer drug design. 10(2)
A variety of spectroscopic and biochemical techniques have been employed to investigate the extent to which binding to DNA of an intercalator (amsacrine or its 4-carboxamide derivative SN16713) affects the binding of netropsin, a minor groove-targete