Zobrazeno 1 - 10
of 59
pro vyhledávání: '"J P, Fletcher"'
Autor:
A. D. Reed, J. R. Fletcher, Y. Y. Huang, R. Thanissery, A. J. Rivera, R. J. Parsons, A. K. Stewart, D. J. Kountz, A. Shen, E. P. Balskus, C. M. Theriot
Publikováno v:
mSphere, Vol 7, Iss 2 (2022)
ABSTRACT An intact gut microbiota confers colonization resistance against Clostridioides difficile through a variety of mechanisms, likely including competition for nutrients. Recently, proline was identified as an important environmental amino acid
Externí odkaz:
https://doaj.org/article/14ceeff9285f45de842391279dba1aea
Publikováno v:
BMC Neuroscience, Vol 20, Iss 1, Pp 1-10 (2019)
Abstract Background Parkinson’s disease (PD) is characterised by dopaminergic cell loss within the substantia nigra pars compacta (SNc) that leads to reduced striatal dopamine content and resulting motor deficits. Identifying new strategies to prot
Externí odkaz:
https://doaj.org/article/bc2b3464a17249d2937c80ef13208d7f
Publikováno v:
Pharmacology Research & Perspectives, Vol 9, Iss 4, Pp n/a-n/a (2021)
Abstract Parkinson's disease is a highly disabling, progressive neurodegenerative disease that manifests as a mix of motor and non‐motor signs. Although we are equipped with some symptomatic treatments, especially for the motor signs of the disease
Externí odkaz:
https://doaj.org/article/f730110fd360437a87b9a098a3eff3ee
Autor:
J. D. Fletcher, N. Johnson, E. Locane, P. See, J. P. Griffiths, I. Farrer, D. A. Ritchie, P. W. Brouwer, V. Kashcheyevs, M. Kataoka
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
Quantum tomographic techniques enable the complete characterisation of continuous variable quantum states. Here the authors demonstrate a broadband tomography protocol for single electrons that goes beyond the bandwidth restrictions of existing metho
Externí odkaz:
https://doaj.org/article/9f406d46359343a0ab4d5e771c42e07d
Autor:
Emily Clarke, Pawel Stocki, Elizabeth H. Sinclair, Aziz Gauhar, Edward J. R. Fletcher, Alicja Krawczun-Rygmaczewska, Susan Duty, Frank S. Walsh, Patrick Doherty, Julia Lynn Rutkowski
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1335 (2022)
Single domain shark antibodies that bind to the transferrin receptor 1 (TfR1) on brain endothelial cells have been used to shuttle antibodies and other cargos across the blood brain barrier (BBB) to the brain. For these studies the TXB4 brain shuttle
Externí odkaz:
https://doaj.org/article/7e8201a7d0904e04a5f05e9349a1bc37
Autor:
Edward J. R. Fletcher, Clare J. Finlay, Ana Amor Lopez, William R. Crum, Anthony C. Vernon, Susan Duty
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Dyskinesia associated with chronic levodopa treatment in Parkinson’s disease is associated with maladaptive striatal plasticity. The objective of this study was to examine whether macroscale structural changes, as captured by magnetic resonance ima
Externí odkaz:
https://doaj.org/article/728b6f2a2ad5471b9a03e5fa63346c57
Publikováno v:
Science and Technology of Nuclear Installations, Vol 2020 (2020)
Atmospheric dispersion modelling and radiological safety analysis have been performed for a postulated accident scenario of a generic VVER-1000 nuclear power plant using the HotSpot Health Physics code. The total effective dose equivalent (TEDE), the
Externí odkaz:
https://doaj.org/article/4c6f70b018db41af8f8c12e99d532381
Autor:
J. D. Fletcher
Publikováno v:
International Journal of STEM Education, Vol 5, Iss 1, Pp 1-10 (2018)
Abstract This article provides brief comments and reflections on Intelligent Tutoring Systems (ITS) and their use in providing STEM (science, technology, engineering, and mathematics) education and training as described in the four articles prepared
Externí odkaz:
https://doaj.org/article/8818010914e147a585f10d732942fffe
Publikováno v:
Bulletin of Chemical Reaction Engineering & Catalysis, Vol 12, Iss 1, Pp 106-112 (2017)
The use of high throughout and combinatorial experimentation is becoming commonplace in catalytic research. The benefits of parallel experiments are not only limited to reducing the time-to-market, but also give an opportunity to study processes in m
Externí odkaz:
https://doaj.org/article/fdc27731827e49668b65d5e92ad61fb9
Publikováno v:
Geoscientific Model Development, Vol 7, Iss 5, Pp 2107-2120 (2014)
The current operational version of National Centers for Environmental Prediction (NCEP) Global Forecasting System (GFS) shows significant low cloud bias. These biases also appear in the Coupled Forecast System (CFS), which is developed from the GFS.
Externí odkaz:
https://doaj.org/article/6b9f956fda3b41a4be3c4b6e8fc05663