Zobrazeno 1 - 10
of 101
pro vyhledávání: '"J P, Condreay"'
Autor:
S W Ng, K Thompson, M.R.P. Hall, Anton D. Michel, Stefan Senger, J P Condreay, Shilina Roman, Livermore David, W C Clay, J Holbrook
Publikováno v:
British Journal of Pharmacology. 155:738-751
Background and purpose: Several P2X7 receptor antagonists are allosteric inhibitors and exhibit species difference in potency. Furthermore, N2-(3,4-difluorophenyl)-N1-(2-methyl-5-(1-piperazinylmethyl)phenyl)glycinamide dihydrochloride (GW791343) exhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea4d80b2aa745bd6ab67645d6e34e15f
https://doi.org/10.1038/bjp.2008.306
https://doi.org/10.1038/bjp.2008.306
Autor:
Anton D. Michel, D S Levy, J P Condreay, W C Clay, J A Goodwin, Elena Fonfria, G D Smith, Shilina Roman
Publikováno v:
British Journal of Pharmacology. 153:544-556
Background and purpose: The human, rat, and mouse P2X7 receptors have been previously characterized, and in this study we report the cloning and pharmacological properties of the guinea pig orthologue. Experimental approach: A cDNA encoding for the g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4df0c4637904a08d389513cab8b387ad
https://doi.org/10.1038/sj.bjp.0707596
https://doi.org/10.1038/sj.bjp.0707596
Autor:
Iain P. Chessell, Anton D. Michel, Laura J. Chambers, W C Clay, Daryl S. Walter, J P Condreay
Publikováno v:
British Journal of Pharmacology. 151:84-95
Background and Purpose: The P2X7 receptor exhibits complex pharmacological properties. In this study, binding of a [3H]-labelled P2X7 receptor antagonist to human P2X7 receptors has been examined to further understand ligand interactions with this re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed691a1366cfce3cbca0ffceb24fda97
https://doi.org/10.1038/sj.bjp.0707196
https://doi.org/10.1038/sj.bjp.0707196
Autor:
Thomas A. Kost, J P Condreay
Publikováno v:
Current Opinion in Biotechnology. 10:428-433
Baculovirus expression vectors are widely used for expressing heterologous proteins in cultured insect cells. Recent advances include further development of the system for production of multi-subunit protein complexes, co-expression of protein-modify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bacc617d65ed7560c676bd80d9a80521
https://doi.org/10.1016/s0958-1669(99)00005-1
https://doi.org/10.1016/s0958-1669(99)00005-1
Publikováno v:
Antimicrobial Agents and Chemotherapy. 40:520-523
The anti-hepatitis B virus (HBV) activity of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine (524W91) in cultures of primary human hepatocytes was examined. 524W91 was anabolized to the active 5'-triphosphate in these cells. HBV re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa90e76492843fab1540743a472f61e
https://doi.org/10.1128/aac.40.2.520
https://doi.org/10.1128/aac.40.2.520
Autor:
A D, Michel, W C, Clay, S W, Ng, S, Roman, K, Thompson, J P, Condreay, M, Hall, J, Holbrook, D, Livermore, S, Senger
Publikováno v:
British journal of pharmacology. 155(5)
Several P2X(7) receptor antagonists are allosteric inhibitors and exhibit species difference in potency. Furthermore, N(2)-(3,4-difluorophenyl)-N(1)-(2-methyl-5-(1-piperazinylmethyl)phenyl)glycinamide dihydrochloride (GW791343) exhibits negative allo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e2066190402261f64fd89b2be6292cba
https://pubmed.ncbi.nlm.nih.gov/18660826
https://pubmed.ncbi.nlm.nih.gov/18660826
Autor:
J P Condreay, Thomas Kost
Publikováno v:
Current drug targets. 8(10)
Functional expression of recombinant proteins has become a routine, but critical tool in modern molecular biology. Since their introduction, the use of baculovirus vectors to produce proteins for purification has become one of the most widely-used vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ee4618dd86927eacca5ab8919a6d5cf
https://pubmed.ncbi.nlm.nih.gov/17979672
https://pubmed.ncbi.nlm.nih.gov/17979672
Publikováno v:
British journal of pharmacology. 151(1)
The P2X(7) receptor exhibits complex pharmacological properties. In this study, binding of a [(3)H]-labelled P2X(7) receptor antagonist to human P2X(7) receptors has been examined to further understand ligand interactions with this receptor.The P2X(7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4c4d020619144b290dea9340a14d08cb
https://pubmed.ncbi.nlm.nih.gov/17339830
https://pubmed.ncbi.nlm.nih.gov/17339830
Publikováno v:
Journal of virology. 75(2)
Our group and others have recently demonstrated the ability of recombinant baculoviruses to transduce mammalian cells at high frequency. To further characterize the use of baculovirus as a mammalian gene delivery system, we examined the status of tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a4949ad171eedb8f9725823501c1473
https://pubmed.ncbi.nlm.nih.gov/11134303
https://pubmed.ncbi.nlm.nih.gov/11134303
Publikováno v:
Cell Engineering ISBN: 9789401058667
The first papers describing the use of insect cell baculoviruses as expression vectors were published in the early 1980’s (Smith et al., 1983; Pennock et al., 1984). Interestingly, as measured by the number of published papers identified using the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a532532002732f6e8ef91ad6e17e392
https://doi.org/10.1007/978-94-011-4315-8_1
https://doi.org/10.1007/978-94-011-4315-8_1
