Zobrazeno 1 - 10 of 172 pro vyhledávání: '"J Oliver Dolly"'
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Akademický článek
Disruption of myelin leads to ectopic expression of K(V)1.1 channels with abnormal conductivity of optic nerve axons in a cuprizone-induced model of demyelination.
Autor: Bandita Bagchi, Ahmed Al-Sabi, Seshu Kaza, Dimitri Scholz, Valerie B O'Leary, J Oliver Dolly, Saak V Ovsepian
Publikováno v: PLoS ONE, Vol 9, Iss 2, p e87736 (2014)
The molecular determinants of abnormal propagation of action potentials along axons and ectopic conductance in demyelinating diseases of the central nervous system, like multiple sclerosis (MS), are poorly defined. Widespread interruption of myelin o
Externí odkaz: https://doaj.org/article/b2e9988c15d54a3aac934168086d3463
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3
Bipartite Activation of Sensory Neurons by a TRPA1 Agonist Allyl Isothiocyanate Is Reflected by Complex Ca2+ Influx and CGRP Release Patterns: Enhancement by NGF and Inhibition with VAMP and SNAP-25 Cleaving Botulinum Neurotoxins
Autor: Mariia Belinskaia, Jiafu Wang, Seshu Kumar Kaza, Caren Antoniazzi, Tomas Zurawski, J. Oliver Dolly, Gary W. Lawrence
Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 2; Pages: 1338
The trafficking of transient receptor potential (TRP) channels to the plasma membrane and the release of calcitonin gene-related peptide (CGRP) from trigeminal ganglion neurons (TGNs) are implicated in some aspects of chronic migraines. These exocyto
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71dcb20455c7b85f34479048d6cde016
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4
Population Coding of Capsaicin Concentration by Sensory Neurons Revealed Using Ca2+ Imaging of Dorsal Root Ganglia Explants from Adult pirt-GCaMP3 Mouse
Autor: J. Oliver Dolly, Gary W. Lawrence, Tomas H. Zurawski, Xinzhong Dong
Publikováno v: Cellular Physiology and Biochemistry, Vol 55, Iss 4, Pp 428-448 (2021)
Background/Aims: Nociceptors detect noxious capsaicin (CAPS) via the transient receptor potential vanilloid 1 (TRPV1) ion channel, but coding mechanisms for relaying CAPS concentration [CAPS] remain obscure. Prolonged (up to 1h.) exposure to CAPS is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5954e2bd565790976475e19a004479
https://www.cellphysiolbiochem.com/Articles/000394/
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5
Botulinum Neurotoxin Chimeras Suppress Stimulation by Capsaicin of Rat Trigeminal Sensory Neurons In Vivo and In Vitro
Autor: Caren Antoniazzi, Mariia Belinskaia, Tomas Zurawski, Seshu Kumar Kaza, J. Oliver Dolly, Gary W. Lawrence
Publikováno v: Toxins; Volume 14; Issue 2; Pages: 116
Chimeras of botulinum neurotoxin (BoNT) serotype A (/A) combined with /E protease might possess improved analgesic properties relative to either parent, due to inheriting the sensory neurotropism of the former with more extensive disabling of SNAP-25
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d9e8ac30d5bab994793b5541183114
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6
Neurobiology and therapeutic utility of neurotoxins targeting postsynaptic mechanisms of neuromuscular transmission
Autor: Valerie B. O’Leary, J. Oliver Dolly, Naira M. Ayvazyan, Saak V. Ovsepian
Publikováno v: Drug Discovery Today. 24:1968-1984
The neuromuscular junction (NMJ) is the principal site for the translation of motor neurochemical signals to muscle activity. Therefore, the release and sensing machinery of acetylcholine (ACh) along with muscle contraction are two of the main target
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0807e2d8be93ba45471daa024008043b
https://doi.org/10.1016/j.drudis.2019.06.012
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7
Ca
Autor: J. Oliver Dolly, Gary W. Lawrence, Tomas H. Zurawski
Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 5
International Journal of Molecular Sciences, Vol 22, Iss 2589, p 2589 (2021)
Nociceptors sense hazards via plasmalemmal cation channels, including transient receptor potential vanilloid 1 (TRPV1). Nerve growth factor (NGF) sensitises TRPV1 to capsaicin (CAPS), modulates nociceptor excitability and induces thermal hyperalgesia
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c25c01a27975d53e38e2bc06ed58d5c
https://pubmed.ncbi.nlm.nih.gov/33806699
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NGF Enhances CGRP Release Evoked by Capsaicin from Rat Trigeminal Neurons: Differential Inhibition by SNAP-25-Cleaving Proteases
Autor: Mariia Belinskaia, Tomas Zurawski, Seshu Kumar Kaza, Caren Antoniazzi, J. Oliver Dolly, Gary W. Lawrence
Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 2; Pages: 892
International Journal of Molecular Sciences, Vol 23, Iss 892, p 892 (2022)
International Journal of Molecular Sciences
Nerve growth factor (NGF) is known to intensify pain in various ways, so perturbing pertinent effects without negating its essential influences on neuronal functions could help the search for much-needed analgesics. Towards this goal, cultured neuron
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::357374a15cabb47b412fe0c971cd10e8
https://doi.org/10.3390/ijms23020892
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9
A SNAP-25 cleaving chimera of botulinum neurotoxin /A and /E prevents TNFα−induced elevation of the activities of native TRP channels on early postnatal rat dorsal root ganglion neurons
Autor: J. Oliver Dolly, Jianghui Meng, Yamil R. Yusef, Jiafu Wang, Marc Nugent
Publikováno v: Neuropharmacology. 138:257-266
Transient receptor potential (TRP) vallinoid 1 (TRPV1) and ankyrin 1 (TRPA1) are two transducing channels expressed on peripheral sensory nerves involved in pain sensation. Upregulation of their expression, stimulated by inflammatory cytokines and gr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed35ed2841bccb11c6806912ef578129
https://doi.org/10.1016/j.neuropharm.2018.06.016
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10
Amyloid Plaques of Alzheimer’s Disease as Hotspots of Glutamatergic Activity
Autor: J. Oliver Dolly, Valerie B. O'Leary, Saak V. Ovsepian, Laszlo Zaborszky, Vasilis Ntziachristos
Publikováno v: The Neuroscientist. 25:288-297
Deposition of amyloid plaques in limbic and associative cortices is amongst the most recognized histopathologic hallmarks of Alzheimer’s disease. Despite decades of research, there is a lack of consensus over the impact of plaques on neuronal funct
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8115741a1fbfef9b30c186f7f796dce
https://doi.org/10.1177/1073858418791128
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