Zobrazeno 1 - 9
of 9
pro vyhledávání: '"J O Bartus"'
Publikováno v:
Receptor. 1(3)
Incubation of cultured rat aortic smooth muscle cells (A-10) with activators of cyclic nucleotides resulted in transiently increased activity of extractable topoisomerase I or topoisomerase II. ANF, which induces cGMP accumulation, potentiated campto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b2197e09d367066c4c3e7d959c6168e3
https://pubmed.ncbi.nlm.nih.gov/1668830
https://pubmed.ncbi.nlm.nih.gov/1668830
Autor:
G D, Hoke, F L, McCabe, L F, Faucette, J O, Bartus, C M, Sung, B D, Jensen, J R, Heys, G F, Rush, D W, Alberts, R K, Johnson
Publikováno v:
Molecular pharmacology. 39(1)
Bis(diphenylphosphine)ethane (DPPE) and its gold coordination complexes have demonstrated antitumor activity in transplantable tumor models. This report describes the development of a P388 cell line (P388/DPPEc) that is resistant to DPPE and its anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c94eeef59de6aa9401d55e04f2e64056
https://pubmed.ncbi.nlm.nih.gov/1898982
https://pubmed.ncbi.nlm.nih.gov/1898982
Publikováno v:
Biochemical Journal. 262:485-489
Incubation of cultured rat aortic smooth muscle cells (A-10, ATCC CRL 1476) with [8-arginine]vasopressin (AVP) or thrombin increased the amount of DNA strand breakage induced by camptothecin, an inhibitor of topoisomerase I (DNA topoisomerase; EC 5.9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cada1cba9fb0f80cf850a2dff1cd4060
https://doi.org/10.1042/bj2620485
https://doi.org/10.1042/bj2620485
Autor:
Blaine M. Sutton, David T. Hill, D. B. Bryan, Stanley T. Crooke, Leo F. Faucette, Randall K. Johnson, Gerald R. Girard, J O Bartus, Christopher K. Mirabelli, Francis L. McCabe
Publikováno v:
Journal of medicinal chemistry. 30(12)
Bisphosphines related to bis(diphenylphosphino)ethane (dppe) and their gold complexes are described that are active in a spectrum of transplantable tumor models. When administered ip on days 1-5 at its maximally tolerated dose (MTD) of 40 mumol/kg, d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a47462ac8ed4c9b08b986fece1189626
https://pubmed.ncbi.nlm.nih.gov/3681888
https://pubmed.ncbi.nlm.nih.gov/3681888
Autor:
F H, Drake, G A, Hofmann, S M, Mong, J O, Bartus, R P, Hertzberg, R K, Johnson, M R, Mattern, C K, Mirabelli
Publikováno v:
Cancer research. 49(10)
Merbarone has previously been shown to have antitumor activity of unknown mechanism in P388 and L1210 tumor models (A. D. Brewer et al., Biochem. Pharmacol., 34:2047-2050, 1985) and is currently undergoing Phase I clinical trials. Here we report that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4a78cb95becd1181d8c02f6a6ba067a0
https://pubmed.ncbi.nlm.nih.gov/2540903
https://pubmed.ncbi.nlm.nih.gov/2540903
Autor:
Robert P. Hertzberg, Randall K. Johnson, J O Bartus, Shau Ming Mong, Michael R. Mattern, Dalia R. Jakas, Gregory Gallagher, Kenneth G. Holden, Mary Jo Caranfa, William D. Kingsbury
Publikováno v:
Journal of medicinal chemistry. 32(3)
Several camptothecin derivatives containing a modified hydroxy lactone ring have been synthesized and evaluated for inhibition of topoisomerase I and cytotoxicity to mammalian cells. Each of the groups of the hydroxy lactone moiety, the carbonyl oxyg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e64bf81b071908f0e11fe418a95215
https://pubmed.ncbi.nlm.nih.gov/2537428
https://pubmed.ncbi.nlm.nih.gov/2537428
Autor:
Gerald R. Girard, Randall K. Johnson, Stanley T. Crooke, Christopher K. Mirabelli, Francis L. McCabe, J O Bartus, Leo F. Faucette, D. B. Bryan, Blaine M. Sutton, David T. Hill
Publikováno v:
ChemInform. 19
Bisphosphines related to bis(diphenylphosphino)ethane (dppe) and their gold complexes are described that are active in a spectrum of transplantable tumor models. When administered ip on days 1-5 at its maximally tolerated dose (MTD) of 40 mumol/kg, d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a30be8e68c051f396f8e84c56f521d52
https://doi.org/10.1002/chin.198824313
https://doi.org/10.1002/chin.198824313
Autor:
M R, Mattern, K B, Tan, J P, Zimmerman, S M, Mong, J O, Bartus, G A, Hofmann, F H, Drake, R K, Johnson, S T, Crooke, C K, Mirabelli
Publikováno v:
Anti-cancer drug design. 4(2)
CHO-Cdr20 cells are 10-20 times more resistant to killing by cadmium than the parental CHO cells. Resistance has been linked to amplification of the metallothionein genes MT-I and MT-II and their coordinate induction by cadmium and other toxic metals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7c3aaa8db5ac3bb8507f94ea5f192f83
https://pubmed.ncbi.nlm.nih.gov/2478139
https://pubmed.ncbi.nlm.nih.gov/2478139
Autor:
Stanley T. Crooke, Christopher K. Mirabelli, Cheng Po Sung, Shau Ming Mong, Henry F. Bartus, Randall K. Johnson, J O Bartus
Publikováno v:
The Journal of antibiotics. 38(6)
A method is described by which the growth inhibitory effects of cytotoxic compounds and fermentation broth cultures on adherent tumor cell lines can be quantitated. Cells are seeded into 96-well microtiter plates and 16 hours later the test compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25a92f64ff612c5711ef4c5be81e25f6
https://pubmed.ncbi.nlm.nih.gov/4019319
https://pubmed.ncbi.nlm.nih.gov/4019319