Zobrazeno 1 - 8
of 8
pro vyhledávání: '"J O, Peggins"'
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 24:213-223
Multiple doses of arteether (ARTE) at 25 mg/kg cause CNS and anorectic toxicities in rats. The same dose of ARTE was used to study the toxicokinetics (TK) after multiple injections and the pharmacokinetics (PK) following single administration. Animal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f842570b5a9bf0ed9bfe580f907f1dd
https://doi.org/10.1007/bf03190023
https://doi.org/10.1007/bf03190023
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 26(4)
beta-Arteether (AE) is an endoperoxide sesquiterpene lactone derivative currently being developed for the treatment of severe, complicated malaria caused by multidrug-resistant Plasmodium falciparum. Studies were undertaken to determine which form(s)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::25a9dfd3afc4fad9c194465af26b31f4
https://pubmed.ncbi.nlm.nih.gov/9531517
https://pubmed.ncbi.nlm.nih.gov/9531517
Publikováno v:
Pharmaceutical research. 14(10)
To study the reaction of artelinic acid with chemical model systems of cytochrome P-450 as a means of obtaining authentic samples of the putative metabolites necessary for identification of the mammalian metabolites of artelinic acid.Artelinic acid w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::405f796c8adaaff707f6ba95f47b9ea0
https://pubmed.ncbi.nlm.nih.gov/9358560
https://pubmed.ncbi.nlm.nih.gov/9358560
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 23(1)
The in vitro metabolism of the 8-aminoquinoline, 8-(4-amino-1- methylbutylamino-2,6-dimethoxy-4-methyl-5-(3-trifluromethyl- phenoxy)quinoline (WR 238605), by rat liver microsomes was studied. After incubation of WR 238605 with rat liver microsomes, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::75887fab414c9b62711c86c65e700044
https://pubmed.ncbi.nlm.nih.gov/7720510
https://pubmed.ncbi.nlm.nih.gov/7720510
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 23(1)
Primaquine, 8-(4-amino-1-methylbutylamino)-6-methoxyquinoline, is an antimalarial 8-aminoquinoline derivative. Although it has been in use since 1952, its metabolism has not been clearly defined. This is due to the instability of the expected aminoph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cf88f5dcd41f821c48daf2f218483347
https://pubmed.ncbi.nlm.nih.gov/7720521
https://pubmed.ncbi.nlm.nih.gov/7720521
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 22(3)
Malaria is a major cause of health problems in a large portion of the world. The 8-aminoquinoline compound, primaquine, is one of the only compounds useful for relapses of Plasmodium vivax and Plasmodium ovale malaria. Primaquine has several toxiciti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9e55c36612634495a9e9e79b65f73af4
https://pubmed.ncbi.nlm.nih.gov/8070311
https://pubmed.ncbi.nlm.nih.gov/8070311
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 20(5)
1. Age-related changes in hepatic hydroxylation of azoxymethane (AZO) to methylazoxymethanol (MAM), as well as colonic phase I metabolism of MAM by alcohol dehydrogenase (ADH) were examined in young (2-4 months), middle-aged (12-14 months), and old (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c32986bba1bf7855b98d330d1c2ab61
https://pubmed.ncbi.nlm.nih.gov/2112289
https://pubmed.ncbi.nlm.nih.gov/2112289
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 15(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::236c4e2349d302a41463b05a12b65cd6
https://pubmed.ncbi.nlm.nih.gov/2882990
https://pubmed.ncbi.nlm.nih.gov/2882990