Zobrazeno 1 - 10
of 5 069
pro vyhledávání: '"J O'Neill"'
Autor:
Matthew J. O’Neill, Tao Yang, Julie Laudeman, Maria E. Calandranis, M. Lorena Harvey, Joseph F. Solus, Dan M. Roden, Andrew M. Glazer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Interpreting the clinical significance of putative splice-altering variants outside canonical splice sites remains difficult without time-intensive experimental studies. To address this, we introduce Parallel Splice Effect Sequencing (ParSE-
Externí odkaz:
https://doaj.org/article/8f555e7c501b489da69369ad216d2e01
Autor:
Gabrielle A. Hartley, Stephen R. Frankenberg, Natasha M. Robinson, Anna J. MacDonald, Rodrigo K. Hamede, Christopher P. Burridge, Menna E. Jones, Tim Faulkner, Hayley Shute, Karrie Rose, Rob Brewster, Rachel J. O’Neill, Marilyn B. Renfree, Andrew J. Pask, Charles Y. Feigin
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-8 (2024)
Abstract The eastern quoll (Dasyurus viverrinus) is an endangered marsupial native to Australia. Since the extirpation of its mainland populations in the 20th century, wild eastern quolls have been restricted to two islands at the southern end of the
Externí odkaz:
https://doaj.org/article/97aebde6cfec494c85d37c8f1bc550dc
Autor:
Matthias Pfeifer, Jonathan S. Brammeld, Stacey Price, James Pilling, Deepa Bhavsar, Anca Farcas, Jessica Bateson, Anjana Sundarrajan, Ricardo J. Miragaia, Nin Guan, Stephanie Arnold, Laiba Tariq, Michael Grondine, Sarah Talbot, Maria Lisa Guerriero, Daniel J. O’Neill, Jamie Young, Carlos Company, Shanade Dunn, Hannah Thorpe, Matthew J. Martin, Kimberly Maratea, Daniel Barrell, Miika Ahdesmaki, Jerome T. Mettetal, Functional Genomics Centre, James Brownell, Ultan McDermott
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract Most lung cancer patients with metastatic cancer eventually relapse with drug-resistant disease following treatment and EGFR mutant lung cancer is no exception. Genome-wide CRISPR screens, to either knock out or overexpress all protein-codin
Externí odkaz:
https://doaj.org/article/ed715ab2efbd4a99b27d7f1bbae4d95d
Autor:
Rocio Sanchez-Gallardo, Paula M. O’Connor, Ian J. O’Neill, Brian McDonnell, Ciaran Lee, Rebecca L. Moore, Fionnuala M. McAuliffe, Paul D. Cotter, Douwe van Sinderen
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
Bacteriocins are broad or narrow-spectrum antimicrobial compounds that have received significant scientific attention due to their potential to treat infections caused by antibiotic-resistant pathogenic bacteria. The genome of Bifidobacterium pseudoc
Externí odkaz:
https://doaj.org/article/ae577354e2314282907f25466435ad2f
Autor:
Lisa Friess, Francesca Bottacini, Fionnuala M. McAuliffe, Ian J. O’Neill, Paul D. Cotter, Ciaran Lee, Jose Munoz-Munoz, Douwe van Sinderen
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
ABSTRACTMembers of the genus Bifidobacterium are commonly found in the human gut and are known to utilize complex carbohydrates that are indigestible by the human host. Members of the Bifidobacterium longum subsp. longum taxon can metabolize various
Externí odkaz:
https://doaj.org/article/9e7f402f002f4507b90ebce58dd1cbf2
Autor:
Jay C. Horvat, Richard Y. Kim, Natasha Weaver, Christopher Augood, Alexandra C. Brown, Chantal Donovan, Pierrick Dupre, Lakshitha Gunawardhana, Jemma R. Mayall, Nicole G. Hansbro, Avril A. B. Robertson, Luke A. J. O’Neill, Matthew A. Cooper, Elizabeth G. Holliday, Philip M. Hansbro, Peter G. Gibson
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-14 (2023)
Abstract Background Increased airway NLRP3 inflammasome-mediated IL-1β responses may underpin severe neutrophilic asthma. However, whether increased inflammasome activation is unique to severe asthma, is a common feature of immune cells in all infla
Externí odkaz:
https://doaj.org/article/60288ffe24fd40148d0b5a1960f9d444
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
CARD-BCL10-MALT1 (CBM) signalosomes connect distal signaling of innate and adaptive immune receptors to proximal signaling pathways and immune activation. Four CARD scaffold proteins (CARD9, 10, 11, 14) can form seeds that nucleate the assembly of BC
Externí odkaz:
https://doaj.org/article/a5408c1324fe4188b62473466bc0a7b6
Publikováno v:
Evolutionary Applications, Vol 17, Iss 4, Pp n/a-n/a (2024)
Abstract DNA methylation is critical to the regulation of transposable elements and gene expression and can play an important role in the adaptation of stress response mechanisms in plants. Traditional methods of methylation quantification rely on bi
Externí odkaz:
https://doaj.org/article/e115d3a507584b58874f40f330af12c2
Autor:
Christopher V McCabe, Peter D Price, Gemma F Codner, Alasdair J Allan, Adam Caulder, Skevoulla Christou, Jorik Loeffler, Matthew Mackenzie, Elke Malzer, Joffrey Mianné, Krystian J Nowicki, Edward J O'Neill, Fran J Pike, Marie Hutchison, Benoit Petit-Demoulière, Michelle E Stewart, Hilary Gates, Sara Wells, Nicholas D Sanderson, Lydia Teboul
Publikováno v:
PLoS Genetics, Vol 20, Iss 3, p e1011187 (2024)
BackgroundRecent developments in CRISPR/Cas9 genome-editing tools have facilitated the introduction of precise alleles, including genetic intervals spanning several kilobases, directly into the embryo. However, the introduction of donor templates, vi
Externí odkaz:
https://doaj.org/article/bb312da1ed8649b9bf1f17a2c3bba609
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Ocean warming favors pelagic tunicates, such as salps, that exhibit increasingly frequent and rapid population blooms, impacting trophic dynamics and composition and human marine-dependent activities. Salp blooms are a result of their succes
Externí odkaz:
https://doaj.org/article/d535b866e2c445e2a5ee22e591eae53a