Zobrazeno 1 - 10
of 577
pro vyhledávání: '"J Novick"'
Autor:
Ali Fatehi Hassanabad, MD, MSc, Friederike I. Schoettler, MD, William D.T. Kent, MD, MSc, Corey A. Adams, MD, MSc, Daniel D. Holloway, MD, MSc, Imtiaz S. Ali, MD, Richard J. Novick, MD, MSc, Muhammad R. Ahsan, MBBS, Robert Scott McClure, MD, MSc, Ganesh Shanmugam, MD, William T. Kidd, MD, Teresa M. Kieser, MD, PhD, Paul W.M. Fedak, MD, PhD, Justin F. Deniset, PhD
Publikováno v:
JTCVS Open, Vol 16, Iss , Pp 389-400 (2023)
Objectives: Cardiac surgery using cardiopulmonary bypass contributes to a robust systemic inflammatory process. Local intrapericardial postsurgical inflammation is believed to trigger important clinical implications, such as postoperative atrial fibr
Externí odkaz:
https://doaj.org/article/77fb7a8e72644a0fb844c0a7ac7a2e72
Autor:
Ali Fatehi Hassanabad, MD, MSc, Friederike I. Schoettler, MD, William D.T. Kent, MD, MSc, Corey A. Adams, MD, MSc, Daniel D. Holloway, MD, MSc, Imtiaz S. Ali, MD, Richard J. Novick, MD, MSc, Muhammad R. Ahsan, MBBS, Robert Scott McClure, MD, MSc, Ganesh Shanmugam, MD, William T. Kidd, MD, Teresa M. Kieser, MD, PhD, Paul W.M. Fedak, MD, PhD, Justin F. Deniset, PhD
Publikováno v:
JTCVS Open, Vol 12, Iss , Pp 118-136 (2022)
Objective: There is a paucity of data on the inflammatory response that takes place in the pericardial space after cardiac surgery. This study provides a comprehensive assessment of the local postoperative inflammatory response. Methods: Forty-three
Externí odkaz:
https://doaj.org/article/104f69dfe5ae4b8cb7ab78cb2efbf00e
Autor:
Christoph Rader, Adrian Wiestner, Jing Chang, Matthew G Cyr, Maissa Mhibik, Junpeng Qi, Haiyong Peng, Erika M Gaglione, David Eik, John Herrick, Thomas Venables, Scott J Novick, Valentine V Courouble, Patrick R Griffin
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 11 (2022)
Background Despite numerous therapeutic options, safe and curative therapy is unavailable for most patients with chronic lymphocytic leukemia (CLL). A drawback of current therapies such as the anti-CD20 monoclonal antibody (mAb) rituximab is the elim
Externí odkaz:
https://doaj.org/article/540fafe660a248c8baf6af7c92d6611f
Autor:
Shanwen Zhang, Qian Ren, Scott J. Novick, Timothy S. Strutzenberg, Patrick R. Griffin, Huan Bao
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Circularised nanodiscs (cNDs) are able to stabilise large lipid bilayer patches and are used for structural and functional studies. Current techniques to build cNDs have numerous steps and low yields; here the authors report a single step constructio
Externí odkaz:
https://doaj.org/article/abcf045a3b4d48039b28f9381ec9e24a
Autor:
Mia Shin, Edmond R. Watson, Albert S. Song, Jeffrey T. Mindrebo, Scott J. Novick, Patrick R. Griffin, R. Luke Wiseman, Gabriel C. Lander
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The human mitochondrial protease LONP1 is an AAA+ ATP-dependent quality control protease. Here, the authors present the cryo-EM structures of human LONP1 in three distinct states and provide insights into the mechanism and regulation of this importan
Externí odkaz:
https://doaj.org/article/bb66b8ea8165482a8ae94b393309ce0d
Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ
Autor:
Zahra Heidari, Ian M. Chrisman, Michelle D. Nemetchek, Scott J. Novick, Anne-Laure Blayo, Trey Patton, Desiree E. Mendes, Philippe Diaz, Theodore M. Kamenecka, Patrick R. Griffin, Travis S. Hughes
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The repressive states of peroxisome proliferator-activated receptor γ (PPARγ) are ill-defined, despite nuclear receptors being a major drug target. Here authors demonstrate multiple structurally distinct repressive states, providing a structural ra
Externí odkaz:
https://doaj.org/article/27b2fda7dc814baabc2b2a797db6f945
Autor:
Saswata Deb, Steve K. Singh, Domingos de Souza, Michael W. A. Chu, Richard Whitlock, Steven R. Meyer, Subodh Verma, Anders Jeppsson, Ayman Al-Saleh, Katheryn Brady, Purnima Rao-Melacini, Emilie P. Belley-Cote, Derrick Y. Tam, P. J. Devereaux, Richard J. Novick, Stephen E. Fremes, on behalf of The SUPERIOR SVG Study Investigators
Publikováno v:
Journal of Cardiothoracic Surgery, Vol 14, Iss 1, Pp 1-10 (2019)
Abstract Background Single centre studies support No Touch (NT) saphenous vein graft (SVG) harvesting technique. The primary objective of the SUPERIOR SVG study was to determine whether NT versus conventional (CON) SVG harvesting was associated with
Externí odkaz:
https://doaj.org/article/52e6a3deb4c04fe4877938bc82a1025b
Autor:
Jie Zheng, Chen Wang, Mi Ra Chang, Swapnil C. Devarkar, Brandon Schweibenz, Gogce C. Crynen, Ruben D. Garcia-Ordonez, Bruce D. Pascal, Scott J. Novick, Smita S. Patel, Joseph Marcotrigiano, Patrick R. Griffin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
RIG-I is a critical receptor in the induction of innate immune responses, but mutations in RIG-I can be associated with hyperactive signalling and autoimmune disease. Here Zheng et al. apply HDX-MS approaches to reveal dysregulated checkpoints that r
Externí odkaz:
https://doaj.org/article/8317c8b61e4844eb852d67a0ef3d5f02
Autor:
Thomas K. Green, Matthew Vanagel, Anil Damarancha, Brandon Showalter, Scott J. Novick, Harvinder Chagger Maniar
Publikováno v:
Journal of Chemical Education. 100:745-750
Autor:
A. Dave Nagpal, Andrea Cowan, Linna Li, Graeme Nusca, Linrui Guo, Richard J. Novick, Chris C. Harle, Andrew A. House, Stephanie Fox, Philip M. Jones
Publikováno v:
Canadian Journal of Kidney Health and Disease, Vol 7 (2020)
Background: Despite decades of investigation, the balance of clinical risks and benefits of fluid supplementation with starch remain unresolved. Patient-centered outcomes have not been well explored in a “real-world” trial in cardiac surgery. Obj
Externí odkaz:
https://doaj.org/article/6009d814801b440883d76969cb386ac5