Zobrazeno 1 - 10
of 80
pro vyhledávání: '"J Nikolić-Zugić"'
Publikováno v:
The Journal of Immunology. 159:3866-3874
The effect of age on the diversity of the murine Ig heavy chain repertoire has been studied in unimmunized C57BL/6 mice. We examined the heterogeneity of complementarity-determining region 3 (CDR3) sizes of Ig mRNA of the IgM and IgG isotypes using t
Publikováno v:
The Journal of Immunology. 158:2527-2534
Apoptosis plays an essential role in the development and homeostasis of the immune system. During lymphocyte development, potentially autoreactive cells are eliminated via the activation of a tightly regulated cell death program(s). Similar processes
Autor:
J Nikolić-Zugić, Karen Onel, Dalit Ashany, Elizabeth Lacy, Carolyn L. Tucek-Szabo, Keith B. Elkon
Publikováno v:
European Journal of Immunology. 25:2940-2947
Mice defective in Fas-mediated apoptosis (lpr phenotype) have an intrinsic B cell abnormality that predisposes them to autoantibody production. To investigate potential roles for the Fas receptor (FasR) in B cell tolerance, FasR expression and functi
Autor:
J Nikolić-Zugić, Ruben Dyall
Publikováno v:
The Journal of Experimental Medicine
We have previously isolated, and characterized in vitro, two subsets of CD4hi T cell receptor (TCR)hi single positive (SP) thymocytes: CD8- and CD8lo. In this report, we have analyzed phenotypic, functional, and developmental characteristics of these
Publikováno v:
The Journal of Experimental Medicine
Fas-deficient lpr and gld mice develop lymphadenopathy due to the accumulation of T cells with an unusual double negative (DN) (CD4-CD8-) phenotype. Previous studies have shown that these abnormal cells are capable of inducing redirected lysis of cer
Publikováno v:
European Journal of Immunology. 23:2109-2115
CD8lo4lo cells are the immediate precursors of immature CD8hi4loTcRlo, CD8lo4hiTcRlo and CD8hi4hiTcRlo double-positive (DP) thymocytes in the adult murine thymus. These cells are the first subset in the adult thymus to express accessory CD8 and CD4 m
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 164(4)
The murine class I molecule H-2Kb and its natural gene conversion variant, H-2Kbm8, which differs from H-2Kb solely at 4 aa at the bottom of the peptide-binding B pocket, are expressed in coisogenic mouse strains C57BL/6 (B6) and B6.C-H-2bm8 (bm8). T
Publikováno v:
European journal of immunology. 29(12)
Cytotoxicity is a major effector function of CD8(+) T cells. Although mitogen-activated protein kinase (MAP kinase) / extracellular regulatory kinase (ERK) activity is indispensable for cytotoxic activity of most CD8(+) T cells a portion of CD8(+) T
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(8)
After puberty, the thymus undergoes a dramatic loss in volume, in weight and in the number of thymocytes, a phenomenon termed age-associated thymic involution. Recently, it was reported that age-associated thymic involution did not occur in mice expr
Autor:
J Nikolić-Zugić, Ruben Dyall
Publikováno v:
The Journal of Experimental Medicine
The majority ( approximately 70%) of postselection CD4(+) single-positive (SP) thymocytes are CD8(lo)CD4(hi). These cells express very low levels of CD8, undetectable by flow cytofluorimetric (FCM) analysis, but sufficiently high to allow purificatio