Zobrazeno 1 - 10
of 101
pro vyhledávání: '"J Necciari"'
Autor:
Pierre Sie, J Necciari, C Gaud, H Caplain, J. P. Duret, Bernard Boneu, P. d’Azemar, C. Navarro, J P Cambus
Publikováno v:
Thrombosis and Haemostasis. 79:338-341
SummaryVenous thromboembolism may be efficiently treated by once-a-day (o.d.) administration of a high dose of low molecular weight heparin (LMWH) instead of administration of the same total dose in two injections a day (b.i. d.). To reduce the volum
Autor:
J. Necciari, P. Zandberg, R. Cariou, R. G. M. Van Amsterdam, Petitou Maurice, D.G. Meuleman, H.N. Magnani, J. M. Herbert, Jean-C. Lormeau, C. A. A. Van Boeckel
Publikováno v:
Cardiovascular Drug Reviews. 15:1-26
Publikováno v:
Bone. 17:S479-S483
Tiludronate is a bisphosphonate evaluated extensively as an osteoregulator in the treatment of metabolic bone disorders. It is highly polar and has a low and variable oral absorption similar to its related compounds. An absolute bioavailability of ap
Publikováno v:
Journal of Pharmaceutical Sciences. 83:1461-1464
The pharmacokinetics of valproic acid after oral administration of sustained-release formulations were studied in 12 healthy volunteers. The objective of the present study was to find an appropriate mathematical model to describe the complex drug int
Autor:
Y. Berger, G. Kieffer, Jean-Pierre Maffrand, G. Defreyn, E. Vallee, Jean-Marc Herbert, J. Necciari, D. Gouy, D. Frehel
Publikováno v:
Cardiovascular Drug Reviews. 11:180-198
Publikováno v:
Journal of Cardiovascular Pharmacology. 16:S31-S37
Among the antihypertensive agents, calcium antagonists and in particular diltiazem play a leading role. To improve the conditions of diltiazem administration in the treatment of hypertensive patients a galenic formulation allowing administration of a
Publikováno v:
Seminars in thrombosis and hemostasis. 25
Two open, randomized, crossover bioavailability studies were carried out to assess the influence of concurrent antacid medication and food on the bioavailability of clopidogrel. A fed/fasting study was conducted in 12 elderly male subjects. Each subj
Publikováno v:
Seminars in thrombosis and hemostasis. 25
In order to obtain a global assessment of circulating clopidogrel-related products and of the excretion of the drug, the pharmacokinetic behavior and the excretion balance of 14C radioactivity following the administration of a single dose of 75 mg of
Autor:
C H, Pierce, J M, Houle, J P, Dickinson, M, Kindermans, E, Serre-Lacroix, G, Kieffer, J, Necciari
Publikováno v:
Seminars in thrombosis and hemostasis. 25
The influence of clopidogrel 75 mg, given once daily for 10 days on hepatic P-450 mixed function oxidases, was examined by assessing its effect on the disposition of antipyrine, on urinary 6-betahydroxycortisol (6beta-OHC) and on the plasma activity
Publikováno v:
Seminars in thrombosis and hemostasis. 25
The safety, and the pharmacodynamic and pharmacokinetic compatibility of clopidogrel, 75 mg daily, with the cardiac glycoside digoxin, were assessed in 12 healthy male subjects who took digoxin 0.25 mg once daily for 20 days and, in addition, clopido