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Akademický článek

Osmotic disruption of chromatin induces Topoisomerase 2 activity at sites of transcriptional stress

Autor: William H. Gittens, Rachal M. Allison, Ellie M. Wright, George G. B. Brown, Matthew J. Neale

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Abstract Transcription generates superhelical stress in DNA that poses problems for genome stability, but determining when and where such stress arises within chromosomes is challenging. Here, using G1-arrested S. cerevisiae cells, and employing rapi

Externí odkaz: https://doaj.org/article/ad0e51d0d35b4319b2b87cad8f49db70

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Akademický článek

Inhibition of topoisomerase 2 catalytic activity impacts the integrity of heterochromatin and repetitive DNA and leads to interlinks between clustered repeats

Autor: Michalis Amoiridis, John Verigos, Karen Meaburn, William H. Gittens, Tao Ye, Matthew J. Neale, Evi Soutoglou

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)

Abstract DNA replication and transcription generate DNA supercoiling, which can cause topological stress and intertwining of daughter chromatin fibers, posing challenges to the completion of DNA replication and chromosome segregation. Type II topoiso

Externí odkaz: https://doaj.org/article/d7622845b0994768a17aea775ae7a74d

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Akademický článek

Sorption of colored vs. noncolored organic matter by tidal marsh soils

Autor: P. J. Neale, J. P. Megonigal, M. Tzortziou, E. A. Canuel, C. R. Pondell, H. Morrissette

Publikováno v: Biogeosciences, Vol 21, Pp 2599-2620 (2024)

Tidal marshes are significant sources of colored (or chromophoric) dissolved organic carbon (CDOC) to adjacent waters and, as a result, contribute substantially to their optical complexity and ultimately affect their water quality. Despite this, our

Externí odkaz: https://doaj.org/article/f343b23725e54b8e95af7e5e56e91292

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Akademický článek

Repeated mild traumatic brain injury causes sex-specific increases in cell proliferation and inflammation in juvenile rats

Autor: Katie J. Neale, Hannah M. O. Reid, Barbara Sousa, Erin McDonagh, Jamie Morrison, Sandy Shultz, Eric Eyolfson, Brian R. Christie

Publikováno v: Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-20 (2023)

Abstract Childhood represents a period of significant growth and maturation for the brain, and is also associated with a heightened risk for mild traumatic brain injuries (mTBI). There is also concern that repeated-mTBI (r-mTBI) may have a long-term

Externí odkaz: https://doaj.org/article/b8085d1f6f5a4c10b9b8f54c794fcea8

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