Zobrazeno 1 - 10
of 39
pro vyhledávání: '"J Nathaniel, Diehl"'
Autor:
Bartosz Mucha, Shuo Qie, Sagar Bajpai, Vincenzo Tarallo, J. Nathaniel Diehl, Frank Tedeschi, Gao Zhou, Zhaofeng Gao, Samuel Flashner, Andres J. Klein-Szanto, Hanina Hibshoosh, Shimonosono Masataka, Olga S. Chajewski, Ireneusz Majsterek, Dariusz Pytel, Maria Hatzoglou, Channing J. Der, Hiroshi Nakagawa, Adam J. Bass, Kwok-Kin Wong, Serge Y. Fuchs, Anil K. Rustgi, Eckhard Jankowsky, J. Alan Diehl
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Cytoplasmic accumulation of RNA binding protein, hnRNPK in cancer cells is associated with poor prognosis. Here the authors show that SCFFbxo4 E3 ubiquitin ligase-mediated polyubiquitylation of hnRNPK restricts c-Myc translation and limits cancer pro
Externí odkaz:
https://doaj.org/article/fecd2f81e26b43a3b3aad7932728969f
Autor:
J Nathaniel Diehl, Amelia Ray, Lauren B Collins, Andrew Peterson, Kyle C Alexander, Jacob G Boutros, John S Ikonomidis, Adam W Akerman
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0284875 (2023)
The following protocol describes our workflow for isolation and quantification of plasma extracellular vesicles (EVs). It requires limited sample volume so that the scientific value of specimens is maximized. These steps include isolation of vesicles
Externí odkaz:
https://doaj.org/article/be23cf832e4c47009ab89a0074114826
Autor:
Andrew M. Waters, Tala O. Khatib, Bjoern Papke, Craig M. Goodwin, G. Aaron Hobbs, J. Nathaniel Diehl, Runying Yang, A. Cole Edwards, Katherine H. Walsh, Rita Sulahian, James M. McFarland, Kevin S. Kapner, Thomas S.K. Gilbert, Clint A. Stalnecker, Sehrish Javaid, Anna Barkovskaya, Kajal R. Grover, Priya S. Hibshman, Devon R. Blake, Antje Schaefer, Katherine M. Nowak, Jennifer E. Klomp, Tikvah K. Hayes, Michelle Kassner, Nanyun Tang, Olga Tanaseichuk, Kaisheng Chen, Yingyao Zhou, Manpreet Kalkat, Laura E. Herring, Lee M. Graves, Linda Z. Penn, Hongwei H. Yin, Andrew J. Aguirre, William C. Hahn, Adrienne D. Cox, Channing J. Der
Publikováno v:
Cell Reports, Vol 35, Iss 13, Pp 109291- (2021)
Summary: To identify therapeutic targets for KRAS mutant pancreatic cancer, we conduct a druggable genome small interfering RNA (siRNA) screen and determine that suppression of BCAR1 sensitizes pancreatic cancer cells to ERK inhibition. Integrative a
Externí odkaz:
https://doaj.org/article/24ff658919d8494e80b28117e73c541b
Autor:
Irem Ozkan-Dagliyan, J. Nathaniel Diehl, Samuel D. George, Antje Schaefer, Bjoern Papke, Kathleen Klotz-Noack, Andrew M. Waters, Craig M. Goodwin, Prson Gautam, Mariaelena Pierobon, Sen Peng, Thomas S.K. Gilbert, Kevin H. Lin, Onur Dagliyan, Krister Wennerberg, Emanuel F. Petricoin, III, Nhan L. Tran, Shripad V. Bhagwat, Ramon V. Tiu, Sheng-Bin Peng, Laura E. Herring, Lee M. Graves, Christine Sers, Kris C. Wood, Adrienne D. Cox, Channing J. Der
Publikováno v:
Cell Reports, Vol 31, Iss 11, Pp 107764- (2020)
Summary: We address whether combinations with a pan-RAF inhibitor (RAFi) would be effective in KRAS mutant pancreatic ductal adenocarcinoma (PDAC). Chemical library and CRISPR genetic screens identify combinations causing apoptotic anti-tumor activit
Externí odkaz:
https://doaj.org/article/5756388e183142489ccb4823f8985e8f
Autor:
Adam J. Bass, Channing J. Der, Douglas R. Lowy, Adrienne D. Cox, Emanuel F. Petricoin, Kwok-Kin Wong, George Church, Timothy C. Wang, Katherine A. Hoadley, Mariaelena Pierobon, Sarah Derks, Leonie K. de Klerk, Fahire G. Akarca, Zhong Wu, Jin Zhou, Jennifer Liao, Matthew D. Stachler, Alex G. Papageorge, J. Nathaniel Diehl, Devon R. Blake, Richard G. Hodge, Yichen Wang, Antje Schaefer, Haisheng Zhang
Diffuse gastric cancer (DGC) is a lethal malignancy lacking effective systemic therapy. Among the most provocative recent results in DGC has been that of highly recurrent missense mutations in the GTPase RHOA. The function of these mutations has rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a2062b37221a584c9e0557e87fe2a8e
https://doi.org/10.1158/2159-8290.c.6547882.v1
https://doi.org/10.1158/2159-8290.c.6547882.v1
Autor:
Adam J. Bass, Channing J. Der, Douglas R. Lowy, Adrienne D. Cox, Emanuel F. Petricoin, Kwok-Kin Wong, George Church, Timothy C. Wang, Katherine A. Hoadley, Mariaelena Pierobon, Sarah Derks, Leonie K. de Klerk, Fahire G. Akarca, Zhong Wu, Jin Zhou, Jennifer Liao, Matthew D. Stachler, Alex G. Papageorge, J. Nathaniel Diehl, Devon R. Blake, Richard G. Hodge, Yichen Wang, Antje Schaefer, Haisheng Zhang
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32cf2b19817995da9a9a75ad73aa191b
https://doi.org/10.1158/2159-8290.22535578
https://doi.org/10.1158/2159-8290.22535578
Autor:
Adam J. Bass, Channing J. Der, Douglas R. Lowy, Adrienne D. Cox, Emanuel F. Petricoin, Kwok-Kin Wong, George Church, Timothy C. Wang, Katherine A. Hoadley, Mariaelena Pierobon, Sarah Derks, Leonie K. de Klerk, Fahire G. Akarca, Zhong Wu, Jin Zhou, Jennifer Liao, Matthew D. Stachler, Alex G. Papageorge, J. Nathaniel Diehl, Devon R. Blake, Richard G. Hodge, Yichen Wang, Antje Schaefer, Haisheng Zhang
List of Models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a32eefeff46aef947cd43c914935d6ac
https://doi.org/10.1158/2159-8290.22535575
https://doi.org/10.1158/2159-8290.22535575
Autor:
Channing J. Der, Adrienne D. Cox, Udo Rudloff, Krister Wennerberg, Brian M. Wolpin, Andrew J. Aguirre, Dhirendra K. Simanshu, Emanuel F. Petricoin, Sharon L. Campbell, Dominic Esposito, Kirsten L. Bryant, Prson Gautam, Raymond W.S. Ng, Junning Wang, Jonathan M. DeLiberty, Craig M. Goodwin, Jennifer E. Klomp, Richard G. Hodge, Bjoern Papke, J. Nathaniel Diehl, Andrew M. Waters, Andrew O. Anderson, Timothy H. Tran, Mariaelena Pierobon, Ryan D. Thurman, Anne M. Miermont, Nicole M. Baker, G. Aaron Hobbs
Structure factors and crystal information
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216f6e8c4cf83b25972bc99b461169ca
https://doi.org/10.1158/2159-8290.22535650
https://doi.org/10.1158/2159-8290.22535650
Autor:
Adrienne D. Cox, Channing J. Der, Emanuel F. Petricoin, Kris C. Wood, G. Aaron Hobbs, J. Nathaniel Diehl, Kathryn N. Lambert, Andrew M. Waters, Da'Jhnae Gambrell-Sanders, Mariaelena Pierobon, Frances L. Massey, Victoria V. Nguyen, Craig M. Goodwin, Antje Schaefer, Sehrish Javaid
Supplementary Table from Concurrent Inhibition of ERK and Farnesyltransferase Suppresses the Growth of HRAS Mutant Head and Neck Squamous Cell Carcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1af920e77927c4e8025b959ab08c7032
https://doi.org/10.1158/1535-7163.22522299
https://doi.org/10.1158/1535-7163.22522299
Autor:
Adrienne D. Cox, Channing J. Der, Emanuel F. Petricoin, Kris C. Wood, G. Aaron Hobbs, J. Nathaniel Diehl, Kathryn N. Lambert, Andrew M. Waters, Da'Jhnae Gambrell-Sanders, Mariaelena Pierobon, Frances L. Massey, Victoria V. Nguyen, Craig M. Goodwin, Antje Schaefer, Sehrish Javaid
Supplementary Data from Concurrent Inhibition of ERK and Farnesyltransferase Suppresses the Growth of HRAS Mutant Head and Neck Squamous Cell Carcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e1e2d68c6ccd0a9bc7874fcb47f0517
https://doi.org/10.1158/1535-7163.22522308.v1
https://doi.org/10.1158/1535-7163.22522308.v1