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The impact of aromatase mechanism on other P450s

Autor: J. N. Wright, Peter Lee-Robichaud, M. E. Akhtar, M. Akhtar

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 61:127-132

Experimental findings from a number of laboratories have converged to show that the conversion of androgens into oestrogen, catalysed by aromatase, involves three distinct reactions which occur at a single active site. That each one of these reaction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4c3c56c0f999163e0aa38ca777f48cb
https://doi.org/10.1016/s0960-0760(97)80003-9

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Crystallization and preliminary X-ray diffraction analysis of calexcitin fromLoligo pealei: a neuronal protein implicated in learning and memory

Autor: R. Gill, Fiyaz Mohammed, J. Vernon, J. N. Wright, Peter T. Erskine, Jonathan B. Cooper, K. P. Giese, Steve P. Wood, G. D. E. Beaven

Publikováno v: Acta Crystallographica Section F Structural Biology and Crystallization Communications. 61:879-881

The neuronal protein calexcitin from the long-finned squid Loligo pealei has been expressed in Escherichia coli and purified to homogeneity. Calexcitin is a 22 kDa calcium-binding protein that becomes up-regulated in invertebrates following Pavlovian

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68dbec7c4ce3f5ab6ad5dfd787ed5e08
https://doi.org/10.1107/s1744309105026758

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A transition from ionic to free-radical mechanisms in chemistry and enzymology

Autor: P. Robichaud, A. Z. Shyadehi, Muhammad Akhtar, J. N. Wright

Publikováno v: Pure and Applied Chemistry. 66:2387-2390

Examples were presented of enzymes which catalyse different generic reactions at the same These enzymes which belong to the P-450 class are aromatase, 1401- active site. demethylase, 17a-hydroxylase-17,20-lyase and nitric oxide synthase. 2) The multi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::62c35f408d9c7024f76c0d968e0a9ad0
https://doi.org/10.1351/pac199466102387

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Akademický článek

Intraoperative Resection Guidance and Rapid Pathological Diagnosis of Osteosarcoma using B7H3 Targeted Probe under NIR‐II Fluorescence Imaging.

Autor: Zeng, Fanwei¹ (AUTHOR), Li, Changjian² (AUTHOR), Wang, Han¹ (AUTHOR), Wang, Yueqi³ (AUTHOR), Ren, Tingting¹ (AUTHOR), He, Fangzhou¹ (AUTHOR), Jiang, Jie¹ (AUTHOR), Xu, Jiuhui¹ (AUTHOR), Wang, Boyang¹ (AUTHOR), Wu, Yifan¹ (AUTHOR), Yu, Yiyang¹ (AUTHOR), Hu, Zhenhua³ (AUTHOR) zhenhua.hu@ia.ac.cn, Tian, Jie^2,3 (AUTHOR) jie.tian@ia.ac.cn, Wang, Shidong¹ (AUTHOR) stonewang@bjmu.edu.cn, Tang, Xiaodong¹ (AUTHOR) tang15877@126.com

Publikováno v: Advanced Science. 9/4/2024, Vol. 11 Issue 33, p1-15. 15p.

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Akademický článek

Food selection of tree seeds under three-week laboratory conditions in the bank vole and yellow-necked mouse.

Autor: MÜHLBÖCK, Peter¹ peter.muehlboeck@drei.at, ŠERÁ, Božena² bozena.sera@uniba.sk, SEDLÁČEK, František¹ fsedlac@prf.jcu.cz

Publikováno v: Journal of Vertebrate Biology. 7/19/2024, Vol. 73 Issue 24040, p1-14. 14p.

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Akademický článek

Does Patellar Height Influence Range of Motion and Anterior Knee Pain after Distal Femur Endoprosthesis Reconstruction?

Autor: Sambri, Andrea¹ (AUTHOR) andrea_sambri@libero.it, Paganelli, Chiara¹ (AUTHOR) stefania.parisi@ior.it, Parisi, Stefania Claudia¹ (AUTHOR) matteo.filippini@ior.it, Filippini, Matteo¹ (AUTHOR) marta.bortoli@ior.it, Cevolani, Luca² (AUTHOR) luca.cevolani@ior.it, Stimolo, Davide³ (AUTHOR) davide.stimolo@unifi.it, Bortoli, Marta¹ (AUTHOR) alessandro.bruschi@aosp.bo.it, Guarino, Andrea³ (AUTHOR) andrea.guarino@unifi.it, Bruschi, Alessandro¹ (AUTHOR) michele.fiore@aosp.bo.it, Fiore, Michele¹ (AUTHOR) massimiliano.depaolis@aosp.bo.it, Campanacci, Domenico Andrea³ (AUTHOR) domenico.campanacci@unifi.it, Donati, Davide Maria² (AUTHOR) davide.donati@ior.it, De Paolis, Massimiliano¹ (AUTHOR)

Publikováno v: Journal of Clinical Medicine. Jul2024, Vol. 13 Issue 14, p4194. 9p.

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Crystallization and preliminary X-ray diffraction analysis of the protease from Southampton norovirus complexed with a Michael acceptor inhibitor

Autor: Paul R. Lambden, Leighton Coates, R. J. Hussey, Steve P. Wood, Ian N. Clarke, P. T. Erskine, Jonathan B. Cooper, J. N. Wright, S. Coker, R. Broadbridge, Peter M. Shoolingin-Jordan, M. Sarwar, R. Gill

Noroviruses are the predominant cause of human epidemic nonbacterial gastroenteritis. Viral replication requires a cysteine protease that cleaves a 200 kDa viral polyprotein into its constituent functional parts. Here, the crystallization of the reco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c862cde6562c4ed741984900230ac75b
https://europepmc.org/articles/PMC3001671/

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Crystallization and preliminary X-ray diffraction analysis of L-threonine dehydrogenase (TDH) from the hyperthermophilic archaeon Thermococcus kodakaraensis

Autor: J. N. Wright, Muhammad Akhtar, Jonathan B. Cooper, Alun R. Coker, Peter T. Erskine, Naeem Rashid, Farrukh Jamil, A. Bowyer, Qamar Bashir, Halina Mikolajek

Publikováno v: Acta crystallographica. Section F, Structural biology and crystallization communications. 64(Pt 9)

The enzyme L-threonine dehydrogenase catalyses the NAD(+)-dependent conversion of L-threonine to 2-amino-3-ketobutyrate, which is the first reaction of a two-step biochemical pathway involved in the metabolism of threonine to glycine. Here, the cryst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b248ea0723b6d578786365367613ed55
https://pubmed.ncbi.nlm.nih.gov/18765916

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