Zobrazeno 1 - 10
of 30
pro vyhledávání: '"J N Skepper"'
Publikováno v:
Oncogene. 28:2128-2141
The binding of Bcl-2 to Beclin-1 reduces Beclin-1's capacity to induce autophagy. Here, we have tested whether the interaction is reciprocated by loss of Bcl-2's anti-apoptotic function. We targeted Bcl-2 to mitochondria or endoplasmic reticulum (ER)
Autor:
S, Chen, A E, Goode, J N, Skepper, A J, Thorley, J M, Seiffert, K F, Chung, T D, Tetley, M S P, Shaffer, M P, Ryan, A E, Porter
Publikováno v:
Journal of microscopy. 261(2)
Electron microscopy has been applied widely to study the interaction of nanomaterials with proteins, cells and tissues at nanometre scale. Biological material is most commonly embedded in thermoset resins to make it compatible with the high vacuum in
Publikováno v:
Scopus-Elsevier
We reported that administration of anti-tumor necrosis factor alpha (anti-TNF-alpha) antibodies exacerbates the course of a Salmonella infection in both susceptible and resistant mice by preventing the suppression of bacterial growth in the reticuloe
Publikováno v:
Pharmacology. 63(2)
Adenosine 5'-triphosphate (ATP) is known to play a significant role as a neurotransmitter in smooth muscle. There is evidence to show that ATP can cause bladder contractions and may also be involved in the processing of sensory information in the uri
Publikováno v:
Journal of virology. 75(12)
Herpes simplex virus (HSV) nucleocapsids acquire an envelope by budding through the inner nuclear membrane, but it is uncertain whether this envelope is retained during virus maturation and egress or whether mature progeny virions are derived by deen
Publikováno v:
Journal of neurocytology. 29(9)
The significance of neuronal intranuclear inclusions (NIIs) and extranuclear inclusions (ENNIs) in the brains of patients with polyglutamine repeat diseases and transgenic mice modelling these diseases is hotly debated. We examined inclusions in the
Publikováno v:
Journal of muscle research and cell motility. 21(1)
The effect of loop diuretics at concentrations known to influence cellular water entry coupled to Na-K-Cl co-transport, upon the vacuolation and detubulation following osmotic shock, was investigated in amphibian skeletal muscles. These were exposed
Autor:
J N, Skepper, I, Karydis, M R, Garnett, L, Hegyi, S J, Hardwick, A, Warley, M J, Mitchinson, N R, Cary
Publikováno v:
The Journal of pathology. 188(1)
This study examines ion homeostasis in monocyte-macrophages committed to death by apoptosis. X-ray microanalysis has been used to demonstrate that intracellular concentrations of potassium decreased whilst those of sodium increased following 3 h of e
Cardiac glycosides inhibit detubulation in amphibian skeletal muscle fibres exposed to osmotic shock
Publikováno v:
Journal of muscle research and cell motility. 20(1)
It has recently been suggested that the 'vacuolation' of the transverse tubular system that follows the imposition of an osmotic shock is a component process in the eventual 'detubulation' of amphibian skeletal muscle. However, such a hypothesis requ
Publikováno v:
Microscopy research and technique. 42(5)
The cell populations in the dorsal motor nucleus of the vagus (DMNV) of the rat were studied by light microscopy and transmission electron microscopy, including retrograde labeling with horseradish peroxidase and histochemical demonstration of the di