Zobrazeno 1 - 10 of 12 pro vyhledávání: '"J N Samsom"'
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Akademický článek
TGFβR signalling controls CD103+CD11b+ dendritic cell development in the intestine
Autor: C. C. Bain, J. Montgomery, C. L. Scott, J. M. Kel, M. J. H. Girard-Madoux, L. Martens, T. F. P. Zangerle-Murray, J. Ober-Blöbaum, D. Lindenbergh-Kortleve, J. N. Samsom, S. Henri, T. Lawrence, Y. Saeys, B. Malissen, M. Dalod, B. E. Clausen, A. McI. Mowat
Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Developmental cues for the different dendritic cell (DC) subsets in the intestine are yet to be defined. Here the authors show that TGFβR1 signalling is needed for development of CD103+CD11b+ intestinal DCs from CD103−CD11b+ cells and that they co
Externí odkaz: https://doaj.org/article/4581ca774d5841c890557730e8ad8bd2
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2
P064 High intestinal Secretory Leukocyte Protease Inhibitor (SLPI) expression correlates with abundant neutrophilic inflammation and identifies Inflammatory Bowel Disease patients with a strong IL-17 response
Autor: S Nugteren, B Calado, Y Simons-Oosterhuis, D H Hulleman-van Haaften, R Klomberg, B Tuk, M Charrout, D J Lindenbergh-Kortleve, W K Smits, M Doukas, M A Sanders, G van Beek, J C Escher, L de Ridder, J N Samsom
Publikováno v: Journal of Crohn's and Colitis. 17:i232-i233
Background Inflammatory bowel disease, comprising Crohn’s disease (CD) and ulcerative colitis (UC), is driven by aberrant host-microbial immune interactions. Disease heterogeneity and severity hamper effective treatment, thus new therapeutic strate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e6212f2541afdfdb0f5e52ce69ed411
https://doi.org/10.1093/ecco-jcc/jjac190.0194
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3
OP39 The effect of phenotype and genotype on the plasma proteome in patients with Inflammatory Bowel Disease
Autor: A R Bourgonje, S Hu, L M Spekhorst, D V Zhernakova, A Vich Vila, Y Li, M D Voskuil, L A van Berkel, B Bley Folly, M Charrout, A Mahfouz, M J T Reinders, J I P van Heck, L A B Joosten, M C Visschedijk, H M van Dullemen, K N Faber, J N Samsom, E A M Festen, G Dijkstra, R K Weersma
Publikováno v: Journal of Crohn's and Colitis. 15:S036-S039
Background Protein profiling in patients with inflammatory bowel diseases (IBD) for diagnostic and therapeutic purposes is underexplored. Assessment of interactions between genetics and the plasma proteome could lead to identification of novel diseas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c75c3cbe482a02ee26f2455b8df36c01
https://doi.org/10.1093/ecco-jcc/jjab075.038
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4
P100 Serum inflammatory protein profiling to corroborate selection of therapy naïve moderate-to-severe pediatric Crohn’s disease patients eligible for first-line infliximab treatment
Autor: M M E Jongsma, L M M Costes, I Tindemans, M A Cozijnsen, R H C Raatgreep, M van Pieterson, Y Li, J C Escher, L de Ridder, J N Samsom
Publikováno v: Journal of Crohn's and Colitis. 16:i197-i198
Background Early intervention with biologic therapy, especially with anti-Tumor Necrosis Factor-a, is very effective and now more commonly used to prevent disease progression and complications in Crohn’s disease (CD). However, a rational approach t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::10ab31f0773cc5fa1bf99613a32e9d07
https://doi.org/10.1093/ecco-jcc/jjab232.228
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5
P237 Proteomic analyses do not reveal subclinical inflammation in fatigued patients with quiescent Inflammatory Bowel Disease
Autor: A R Bourgonje, S J Wichers, S Hu, H M van Dullemen, M C Visschedijk, K N Faber, E A M Festen, G Dijkstra, J N Samsom, R K Weersma, L M Spekhorst
Publikováno v: Journal of Crohn's and Colitis. 16:i284-i285
Background Fatigue is a common and clinically challenging symptom in patients with inflammatory bowel diseases (IBD). While fatigue occurs most often in patients with active disease, up to 50% of patients with quiescent disease still report significa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aad2642bb7292c2fe0acf1d00a6f0688
https://doi.org/10.1093/ecco-jcc/jjab232.364
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6
P061 Circulating inflammatory protein and cellular profiles at time of diagnosis classify inflammatory bowel disease patients according to their underlying immune response and clinical disease course
Autor: M Heredia, M Charrout, R C W Klomberg, M A Aardoom, M M E Jongsma, P Kemos, D H van Haaften, B Tuk, L A van Berkel, B Bley Folly, A Mahfouz, M J T Reinders, F Ruemmele, N Croft, J C Escher, L de Ridder, J N Samsom
Publikováno v: Journal of Crohn's and Colitis. 16:i171-i171
Background Chronicity of inflammatory bowel disease (IBD) is driven by reactivation of inflammatory memory CD4+ T helper (Th) cells which activate an inflammatory cascade involving innate immune cells and structural intestinal tissue cells. Because o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67edd0f92e77d29223d0dd6e8b5c1e02
https://doi.org/10.1093/ecco-jcc/jjab232.190
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7
P045 TIGIT expression differentiates regulatory from inflammatory Th1* gut-homing effector CD4+ T cells in inflammatory bowel disease patients
Autor: M Heredia, L M M Costes, I Tindemans, M A Aardoom, R C W Klomberg, P Kemos, M E Joosse, D H van Haaften, B Tuk, F Ruemmele, N M Croft, J C Escher, L de Ridder, J N Samsom
Publikováno v: Journal of Crohn's and Colitis. 16:i161-i161
Background Crohn’s disease (CD) and ulcerative colitis (UC) are characterized by intestinal infiltration of pathogenic effector CD4+ T cells. The defects driving loss of T-cell regulation vary between patients and remain undefined. Previously, we h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5423d28e6f9be4acf3d77c1b74fe97d7
https://doi.org/10.1093/ecco-jcc/jjab232.174
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8
IL-10 signaling in dendritic cells controls IL-1β-mediated IFNγ secretion by human CD4
Autor: S, Veenbergen, P, Li, H C, Raatgeep, D J, Lindenbergh-Kortleve, Y, Simons-Oosterhuis, A, Farrel, L M M, Costes, M E, Joosse, L A, van Berkel, L F, de Ruiter, M A, van Leeuwen, D, Winter, S M, Holland, A F, Freeman, Y, Wakabayashi, J, Zhu, L, de Ridder, G J, Driessen, J C, Escher, W J, Leonard, J N, Samsom
Publikováno v: Mucosal immunology
Uncontrolled interferon γ (IFNγ)-mediated T-cell responses to commensal microbiota are a driver of inflammatory bowel disease (IBD). Interleukin-10 (IL-10) is crucial for controlling these T-cell responses, but the precise mechanism of inhibition r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a3c2cf46092edc5409d229eaadf5dd0f
https://pubmed.ncbi.nlm.nih.gov/31417161
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IL-10 signaling prevents gluten-dependent intraepithelial CD4
Autor: L M M, Costes, D J, Lindenbergh-Kortleve, L A, van Berkel, S, Veenbergen, H R C, Raatgeep, Y, Simons-Oosterhuis, D H, van Haaften, J J, Karrich, J C, Escher, M, Groeneweg, B E, Clausen, T, Cupedo, J N, Samsom
Publikováno v: Mucosal immunology. 12(2)
Breach of tolerance to gluten leads to the chronic small intestinal enteropathy celiac disease. A key event in celiac disease development is gluten-dependent infiltration of activated cytotoxic intraepithelial lymphocytes (IELs), which cytolyze epith
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1b07708455241d434e4f1afeb0b58468
https://pubmed.ncbi.nlm.nih.gov/30542112
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