Výsledky vyhledávání

A case-control study reveals immunoregulatory gene haplotypes that influence inhibitor risk in severe haemophilia A

Autor: J N, Lozier, P S, Rosenberg, J J, Goedert, I, Menashe

Publikováno v: Haemophilia : the official journal of the World Federation of Hemophilia. 17(4)

Several genes that modify risk of factor VIII (FVIII) inhibitors in haemophilia A patients have been identified. Aside from the underlying mutations that cause haemophilia A, inhibitor risk appears to be modified by polymorphisms in various cytokines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dfdfaa5bc4645310a95d559c7f84d31c
https://pubmed.ncbi.nlm.nih.gov/21362111

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Thrombocytopenia and hemostatic disorders in chronic graft versus host disease

Autor: J N Lozier, Dražen Pulanić, S.Z. Pavletic

Publikováno v: Bone marrow transplantation. 44(7)

Chronic graft versus host disease (cGVHD) is a major and frequent late complication in allogeneic stem cell transplantation recipients. Although thrombocytopenia in cGVHD patients is among the most consistent and strongest predictors of poor survival

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b25e33dbdfee80501c69ac3725f9545
https://pubmed.ncbi.nlm.nih.gov/19684626

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Adenovirus-mediated expression of human coagulation factor IX in the rhesus macaque is associated with dose-limiting toxicity

Autor: J N, Lozier, M E, Metzger, R E, Donahue, R A, Morgan

Publikováno v: Blood. 94(12)

We used a first-generation adenovirus vector (AVC3FIX5) to assess whether human factor IX could be expressed and detected in the rhesus macaque, which we have shown does not make high-titer antibodies to human factor IX protein. Three animals receive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::940963afadcd61319b92eeaef75bb77b
https://pubmed.ncbi.nlm.nih.gov/10590039

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The rhesus macaque as an animal model for hemophilia B gene therapy

Autor: J N, Lozier, M E, Metzger, R E, Donahue, R A, Morgan

Publikováno v: Blood. 93(6)

We have determined the 2905 nucleotide sequence of the rhesus macaque factor IX complementary DNA (cDNA) and found it to be greater than 95% identical to that of the human factor IX cDNA. The cDNA has a large 3' untranslated region like the human cDN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d902d4d3e106ba766b593c5126d3b016
https://pubmed.ncbi.nlm.nih.gov/10068660

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Safety profile of porcine factor VIII and its use as hospital and home-therapy for patients with haemophilia-A and inhibitors: the results of an international survey

Autor: C R, Hay, J N, Lozier, C A, Lee, M, Laffan, F, Tradati, E, Santagostino, N, Ciavarella, M, Schiavoni, H, Fukui, A, Yoshioka, J, Teitel, P M, Mannucci, C K, Kasper

Publikováno v: Thrombosis and haemostasis. 75(1)

A multicentre retrospective survey was conducted to re-assess the use of porcine factor VIII (HYATE:C), its side effects and the selection of patients for regular or home-therapy. 15,152,000 units of HYATE:C were used by 154 patients. The median inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::410083da6c98d12c85bec8a92d4cb3af
https://pubmed.ncbi.nlm.nih.gov/8713775

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Porcine factor VIII therapy in patients with congenital hemophilia and inhibitors: efficacy, patient selection, and side effects

Autor: C R, Hay, J N, Lozier, C A, Lee, M, Lafan, H, Tradati, E, Santagostino, N, Ciavarella, M, Schiavoni, H, Fukui, A, Yoshioka

Publikováno v: Seminars in hematology. 31(2 Suppl 4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d50f4355ce3c400a02f1e3a350a28f28
https://pubmed.ncbi.nlm.nih.gov/7939768

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Gene therapy and the hemophilias

Autor: J N, Lozier, K M, Brinkhous

Publikováno v: JAMA. 271(1)

Gene therapy for hemophilia A and B, now in the developmental stage, holds promise of a therapeutic revolution, resulting in amelioration or cure of the hemorrhagic diatheses. The genes for factor VIII and IX have been cloned, and vectors for the tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8ce27161897f950bfd10eb8a5e2f3415
https://pubmed.ncbi.nlm.nih.gov/8182804

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Use of porcine factor VIII for surgical procedures in hemophilia A patients with inhibitors

Autor: J N, Lozier, E, Santagostino, C K, Kasper, J M, Teitel, C R, Hay

Publikováno v: Seminars in hematology. 30(2 Suppl 1)

We have described the use of polyelectrolyte fractionated porcine factor VIII (HYATE:C, Porton Speywood Ltd, Wrexham, UK) to provide hemostasis in 45 patients with hemophilia A complicated by inhibitor antibodies. The cases were collected from hemoph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ba815ba6802788e7b6bd0f224b01fa8f
https://pubmed.ncbi.nlm.nih.gov/8480192

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