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Akademický článek
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Publikováno v:
European Heart Journal. 43
Background and purpose EndMT describes a process in which endothelial cells lose their endothelial features such as the maintenance of the vascular barrier function and trans-differentiate into mesenchymal like cells. ECs which have underwent EndMT a
Autor:
V Filipova, P E Stuerzebecher, S Kralisch, M R Schubert, A Hoffmann, F Oliveira, B Sheikh, M Blueher, A Kogel, M Scholz, K Miehle, T Ebert, U Laufs, A Toenjes, J N Boeckel
Publikováno v:
European Heart Journal. 43
Introduction and purpose Lipodystrophy (LD) syndromes are characterized by the loss of adipose tissue resulting in metabolic complications and accelerated atherosclerosis. The systemic concentration of the adipokine leptin is reduced in LD as a resul
Autor:
M Winkler, J M Kneuer, T Meinecke, M N Moebius-Winkler, R Weiss, J Haas, T Garfias-Veitl, S Von Haehling, T Keller, H Thiele, P Lurz, T Speer, U Laufs, J N Boeckel
Publikováno v:
European Heart Journal. 43
Background and purpose Cardiogenic shock (CS) remains the leading cause of death in acute myocardial infarction (AMI), with high mortality rates of 40–50%. The long non-coding RNA (lncRNA) Heat4 is associated with the inflammatory response of non-c
Autor:
J M Kneuer, M Winkler, T Meinecke, M N Moebius-Winkler, R Weiss, J Haas, T Garfias-Veitl, S Von Haehling, T Keller, H Thiele, P Lurz, T Speer, U Laufs, J N Boeckel
Publikováno v:
European Heart Journal. 43
Background and purpose Activation of the immune system correlates with the severity and the prognosis of patients with heart failure (HF). Here, we aim to identify and characterize long non-coding RNAs (lncRNAs) as a potential mechanistic link betwee
Autor:
S Gaul, K Shahzad, R Medert, I Gadi, C Maeder, D Schumacher, A Wirth, S Fatima, J N Boeckel, H Khawaja, M Brune, P P Nawroth, B Isermann, U Laufs, M Freichel
Publikováno v:
European Heart Journal. 43
Background and aims Atherosclerosis, the main pathology underlying cardiovascular diseases is accelerated in diabetic patients (1,2). Genetic mouse models require breeding efforts which are time-consuming and costly. Our aim was to establish a new no
Publikováno v:
European Heart Journal. 42
Background and purpose Trimethylamine N-oxide (TMAO) is associated with a higher risk of atherosclerotic diseases. However, the underlying molecular mechanisms are not completely understood. Inflammation and following endothelial-to-mesenchymal trans
Autor:
Benjamin Meder, Holger Thiele, M Andritschke, M. Mueller, S Dimmeler, David John, J.-N Boeckel, Ulrich Laufs, Florian Leuschner, Karoline E. Kokot, Jan Haas, M Moebius-Winkler, S Gaul, B Sheikh, J Kneuer
Publikováno v:
European Heart Journal. 42
Background and purpose Post-transcriptional RNA editing is an important mechanism in the development of human diseases. RNA editing can affect RNA stability and alternative splicing. The aim of our study was to characterize RNA editing and its impact
Autor:
Karen Marie Schaeffer, Pablo Pelegrín, Lena Opitz, Ulrich Laufs, Alexander Kogel, Susanne Gaul, Ulf Wagner, Jan Haas, Christina Maeder, Amirhossein Behzadi, J.-N Boeckel, Luisa Uhlmann, Hermann Kalwa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Scientific Reports
Inflammation driven by intracellular activation of the NLRP3 inflammasome is involved in the pathogenesis of a variety of diseases including vascular pathologies. Inflammasome specks are released into the extracellular compartment from disrupting pyr