Zobrazeno 1 - 10
of 18
pro vyhledávání: '"J N, de Hoon"'
Autor:
Carol Addy, Ashley Martucci, Marleen Depré, J. N. de Hoon, Joanna Z. Peng, John A. Wagner, Amy O. Johnson-Levonas, I.N. Gendrano, Rajesh Krishna, S. Aubrey Stoch, Wouter Haazen, Martine Robberechts, Xiaoli S. Glasgow, Daniel Tatosian
Publikováno v:
Journal of Clinical Pharmacology
The pharmacokinetics (PK), and pharmacodynamics (PD) of omarigliptin, a novel once-weekly DPP-4 inhibitor, were assessed following single and multiple doses in healthy subjects. Absorption was rapid and food did not influence single dose PK. Accumula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eac3d7bfddd47c77aeb8b72ff77df0be
https://doi.org/10.1002/jcph.773
https://doi.org/10.1002/jcph.773
Autor:
Sandra M. Sanabria-Bohórquez, J. N. de Hoon, K. Van Laere, Richard Hargreaves, Raymond E. Gibson, Spencer J. Tye, Leslie J. Street, Ruth M. McKernan, I De Lepeleire, Robert W. Carling, Keith A. Wafford, Andrew Pike, John R. Atack, Guy Bormans, Christine Ryan, David James Hallett, HD Burns, M. G Murphy, Wai-Si Eng, A. Van Hecken, G. R. Dawson
Publikováno v:
Journal of Psychopharmacology. 25:329-344
In the accompanying paper we describe how MRK-409 unexpectedly produced sedation in man at relatively low levels of GABAA receptor occupancy (∼10%). Since it was not clear whether this sedation was mediated via the α2/α3 or α1 GABAA subtype(s),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea0a5ae22a6d2851dd26b1e9a8bbbb4
https://doi.org/10.1177/0269881109354928
https://doi.org/10.1177/0269881109354928
Autor:
J. N. de Hoon, Guy Bormans, John R. Atack, M. G Murphy, Sandra M. Sanabria-Bohórquez, I De Lepeleire, A. Van Hecken, Keith A. Wafford, G. R. Dawson, K. Van Laere, Richard Hargreaves, Leslie J. Street, Ruth M. McKernan, Spencer J. Tye, HD Burns
Publikováno v:
Journal of Psychopharmacology. 25:314-328
MRK-409 binds to α1-, α2-, α3- and α5-containing human recombinant GABAA receptors with comparable high affinity (0.21–0.40 nM). However, MRK-409 has greater agonist efficacy at the α3 compared with α1 subtypes (respective efficacies relative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e190b386986f0d8f06dedccdb3ce130
https://doi.org/10.1177/0269881109354927
https://doi.org/10.1177/0269881109354927
Autor:
Eseng Lai, T Laethem, J. N. de Hoon, Tami Crumley, M. Oeyen, I De Lepeleire, C. Thach, A. Van Hecken, Marleen Depré, Larissa Wenning, Kathryn E. Mazina, P. Clement, Keith Gottesdiener, Paul J. Deutsch, J. Van Effen
Publikováno v:
European Journal of Clinical Pharmacology. 63:135-141
Nasal congestion in allergic rhinitis results from tissue edema and vasodilatation in the nasal mucosa. Of the mediators released by mast cells in response to allergens, prostaglandin (PG) D(2) is regarded as the most potent inducer of nasal congesti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31e7e3f68ccd68d5ca2b2636709d0d2
https://doi.org/10.1007/s00228-006-0211-2
https://doi.org/10.1007/s00228-006-0211-2
Autor:
A. Dynder, J. N. de Hoon, M. L. Juliano, Kevin J. Petty, Marleen Depré, Jozef Arnout, Keith Gottesdiener, L. Wildonger, I De Lepeleire, A. Van Hecken
Publikováno v:
Alimentary Pharmacology & Therapeutics. 16:1683-1688
SUMMARY Background : Aspirin is widely used as an anti-thrombotic drug; however, it has been suggested that enteric-coated formulations of aspirin may be less bioavailable and less effective as anti-thrombotic agents. Aim : To assess the effect of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb7be2a8778c3747f1687e40d9493663
https://doi.org/10.1046/j.1365-2036.2002.01332.x
https://doi.org/10.1046/j.1365-2036.2002.01332.x
Publikováno v:
European Journal of Clinical Pharmacology. 58:303-308
To compare the sensitivity of three non-invasive techniques for detecting serotonin (5-HT)(1B/1D)-receptor agonist-induced peripheral vascular effects in humans: the measurement of (1) systolic (SBP) and diastolic (DBP) blood pressures, (2) dorsal ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da94cee7fe399e4dd2cea1af0ecdf0ab
https://doi.org/10.1007/s00228-002-0482-1
https://doi.org/10.1007/s00228-002-0482-1
Autor:
C. Macleod, J. N. de Hoon, Deborah Panebianco, Tae H. Han, Chodakewitz Jeffrey A, I. De Lepeleire, M. G Murphy, Martin O. Behm, William B. Smith, John Palcza, Rebecca L. Blanchard, Marleen Depré
Publikováno v:
Cephalalgia : an international journal of headache. 33(16)
Objective The objective of this article is to assess the effects of sumatriptan monotherapy, telcagepant monotherapy, and their combination on blood pressure (BP) in migraine patients during a headache-free period. Methods A double-blind, placebo-con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82e46433a3056c8d8d2db138b8e00cfb
https://pubmed.ncbi.nlm.nih.gov/23798725
https://pubmed.ncbi.nlm.nih.gov/23798725
Autor:
J. N. de Hoon, F. Guillard, Floris H.M. Vanmolkot, James A. Palmer, A. Van Hecken, B. Van der Schueren, Marleen Depré, Martin W. Lunnon, Bart Laurijssens
Publikováno v:
Journal of clinical pharmacology. 49(3)
The objective of this study was to investigate the pharmacodynamics and pharmacokinetics of a single dose of GW273629, a selective iNOS inhibitor, given during and outside a migraine attack. GW273629 1500 mg was administered to 15 migraine patients b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::581082c9ed3cac02b16c79fc9827fd10
https://pubmed.ncbi.nlm.nih.gov/19246728
https://pubmed.ncbi.nlm.nih.gov/19246728
Autor:
Floris H.M. Vanmolkot, J. N. de Hoon, B. Van der Schueren, I. De Lepeleire, A. Rogiers, Stefanie A. Kane, A. Van Hecken, M Depre, S.R. Sinclair
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 325(1)
The purpose of this study was to identify the mediators involved in capsaicin-induced vasodilation in the human skin and to evaluate a pharmacodynamic model for the early clinical evaluation of calcitonin gene-related peptide (CGRP) receptor antagoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8dec47d7cb4a55283c54e9af9a1e4b3
https://pubmed.ncbi.nlm.nih.gov/18216286
https://pubmed.ncbi.nlm.nih.gov/18216286
Autor:
D Hilliard, I De Lepeleire, J. N. de Hoon, KG Gottesdiener, Fang Liu, A. Van Hecken, Marleen Depré, JA Wagner, Larissa Wenning, E Lai, Gary P. O'Neill, Howard E. Greenberg, Kathleen M. Metters, TM Crumley
Publikováno v:
Clinical pharmacology and therapeutics. 83(6)
Laropiprant is a selective antagonist of the prostaglandin D(2) (PGD(2)) receptor subtype 1 (DP1). Three double-blind, randomized, placebo-controlled studies evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of single and mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5d614f81ee3fea6648d3eb2dcf74e8e
https://pubmed.ncbi.nlm.nih.gov/17882161
https://pubmed.ncbi.nlm.nih.gov/17882161