Zobrazeno 1 - 10
of 59
pro vyhledávání: '"J N, Wells"'
Publikováno v:
European journal of cancer care. 20(2)
This study investigated coping and quality of life in men with prostate cancer (n= 105, 48-86 years of age) and their partners (n= 85, 48-84 years). Participants completed the Abbreviated Dyadic Adjustment Scale, Brief COPE, European Organisation for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::63cd2541fb21a69b6de9b04621fdfebe
https://pubmed.ncbi.nlm.nih.gov/20825459
https://pubmed.ncbi.nlm.nih.gov/20825459
Publikováno v:
Journal of Medicinal Chemistry. 33:1906-1910
8-Substituted xanthines currently represent the most potent class of adenosine-receptor antagonists. A series of 8-substituted 1,3-dipropylxanthines was prepared and their potency as antagonists of A1 and A2 adenosine receptors of human platelets and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1cb0381b4099cef58669fe3f3078a94
https://doi.org/10.1021/jm00169a012
https://doi.org/10.1021/jm00169a012
Publikováno v:
Circulation Research. 66:637-646
The purpose of this study was to test the hypothesis that endogenous adenosine functions to restrain the renin release response to pharmacological and pathophysiological stimuli. To achieve this objective, we examined the effects of an adenosine rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b067cc3814bf68106431d7cd0fc0e62
https://doi.org/10.1161/01.res.66.3.637
https://doi.org/10.1161/01.res.66.3.637
Autor:
I, Feoktistov, E M, Garland, A E, Goldstein, D, Zeng, L, Belardinelli, J N, Wells, I, Biaggioni
Publikováno v:
Biochemical pharmacology. 62(9)
The antiasthmatic drug enprofylline was the first known selective, though not potent, A(2B) antagonist. On the basis of structure-activity relationships (SARs) of xanthine derivatives, we designed a novel selective adenosine A(2B) receptor antagonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::50b2a992e2c4a9177b76a00d37e37049
https://pubmed.ncbi.nlm.nih.gov/11705449
https://pubmed.ncbi.nlm.nih.gov/11705449
Publikováno v:
Molecular pharmacology. 50(4)
Structure-based design of subtype-selective ligands for the A1 adenosine receptor will require a reliable model of the ligand-binding pocket. It should be possible to develop a reliable model based on the results of affinity labeling experiments that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b00e04e430aa7ce2ace04150735d1b62
https://pubmed.ncbi.nlm.nih.gov/8863823
https://pubmed.ncbi.nlm.nih.gov/8863823
Publikováno v:
The Journal of biological chemistry. 271(2)
The alpha 2A adrenergic receptor (alpha 2AAR) previously was shown to be directly delivered to and retained on the lateral subdomain of renal epithelial cells. The present studies demonstrate that, in contrast, wild-type and epitope-tagged canine A1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::56e260dd1e245d8341f5851183f13cdf
https://pubmed.ncbi.nlm.nih.gov/8557716
https://pubmed.ncbi.nlm.nih.gov/8557716
Publikováno v:
Molecular pharmacology. 45(5)
The amino acids that comprise the ligand binding sites of adenosine receptors have not been identified. Adenosine and its agonist analogues differ from ligands for the well studied biogenic amine receptors and rhodopsin in that the adenosine receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f3b464142c17341cfdbf6ab2ba42e710
https://pubmed.ncbi.nlm.nih.gov/8190103
https://pubmed.ncbi.nlm.nih.gov/8190103
Publikováno v:
Molecular pharmacology. 45(5)
We have shown previously that 125I-2-[4-[2-[2-[(4-azidophenyl)methylcarbonylamino] ethylaminocarbonyl]ethyl]phenyl] ethylamino-5'-N-ethylcarboxamidoadenosine (125I-azido-PAPA-APEC) specifically and selectively photolabels RDC8 A2a adenosine receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bf17b75d6088e14d58fa8857cdf8ad72
https://pubmed.ncbi.nlm.nih.gov/8190104
https://pubmed.ncbi.nlm.nih.gov/8190104
Autor:
K R, Sekhar, R J, Hatchett, J B, Shabb, L, Wolfe, S H, Francis, J N, Wells, B, Jastorff, E, Butt, M M, Chakinala, J D, Corbin
Publikováno v:
Molecular pharmacology. 42(1)
Smooth muscle preparations of human aorta or pig coronary arteries contain nearly equal amounts of cGMP-dependent protein kinase isozymes (cGMP kinase I alpha and I beta). In order to understand the roles of these isozymes in relaxing vascular smooth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b6a2cec778465beb633bcc7a3c01dca9
https://pubmed.ncbi.nlm.nih.gov/1321950
https://pubmed.ncbi.nlm.nih.gov/1321950
Publikováno v:
Molecular pharmacology. 39(5)
We have studied the effects of a synthetic peptide that is based on the autoinhibitory domain of protein kinase C on tension development in detergent-permeabilized coronary artery smooth muscle. This peptide inhibited two forms of protein kinase C th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e63cef75acc29449e4a9797adee8c956
https://pubmed.ncbi.nlm.nih.gov/2034234
https://pubmed.ncbi.nlm.nih.gov/2034234