The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438

Autor: J. N. Miner, Colin Farquharson, Syed Faisal Ahmed, Helen C. Owen

Publikováno v: Owen, H C, Miner, J N, Ahmed, S F & Farquharson, C 2007, ' The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438 ', Molecular and Cellular Endocrinology, vol. 264, no. 1-2, pp. 164-70 . https://doi.org/10.1016/j.mce.2006.11.006

Long-term use of glucocorticoids (GC) can cause growth retardation in children due to their actions on growth plate chondrocytes. AL-438, a non-steroidal anti-inflammatory agent that acts through the glucocorticoid receptor (GR) retains full anti-inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::719ad3fc1692a04c724840fcf2c6bcf3
https://pubmed.ncbi.nlm.nih.gov/17182172

Glucocorticoid receptor-cAMP response element-binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids

Autor: E, Imai, J N, Miner, J A, Mitchell, K R, Yamamoto, D K, Granner

Publikováno v: The Journal of biological chemistry. 268(8)

The phosphoenolpyruvate carboxykinase (PEPCK) gene encodes the rate-limiting enzyme in gluconeogenesis. Glucocorticoids enhance PEPCK gene expression through a multicomponent regulatory complex. We show that a full response to glucocorticoids require

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5177870e4989cffee41d385467452c6d
https://pubmed.ncbi.nlm.nih.gov/8449898