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Protein kinase C isoforms α, δ and θ require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells)

Autor: Harald Mischak, Monika Kellerer, E. Seffer, Axel Ullrich, HU Häring, J. Mushack

Publikováno v: Diabetologia. 41:833-838

Protein kinase C (PKC) isoforms are potentially important as modulators of the insulin signalling chain and could be involved in the pathogenesis of cellular insulin resistance. We have previously shown that phorbol ester stimulated PKC beta1 and bet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ffaf5c1659231f80b8c8251e919285
https://doi.org/10.1007/s001250050995

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A 973 valine to methionine mutation of the human insulin receptor: interaction with insulin-receptor substrate-1 and Shc in HEK 293 cells

Autor: B. Bossenmaier, HU Häring, Volker Strack, J. Mushack, Borislav Stoyanov

Publikováno v: Diabetologia. 40:1135-1140

A population-based study in the Netherlands has recently demonstrated that a mutation of the human insulin receptor (HIR-973 valine to methionine) is associated with hyperglycaemia and an increased prevalence of non-insulin-dependent diabetes mellitu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c1a825f9d366abd105cabf8158b7c3
https://doi.org/10.1007/s001250050798

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C-Terminus or Juxtamembrane Deletions in the Insulin Receptor do not Affect the Glucose-Dependent Inhibition of the Tyrosine Kinase Activity

Autor: Hans-Ulrich Häring, Monika Kellerer, E Seffer, Axel Ullrich, Lucia Berti, Mathew Coghlan, J. Mushack, Birgit Bossenmaier, Luitgard Mosthaf, Kenneth Siddle

Publikováno v: European Journal of Biochemistry. 227:787-791

We have previously shown, in rat-1 fibroblasts which stably overexpress high levels of human insulin receptor (HIR), that high glucose levels induce an inhibition of insulin receptor tyrosine kinase (IRK) activity [Berti, L., Mosthaf, L., Kellerer, M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b09cdaf45d935e74007650a5320eb1cf
https://doi.org/10.1111/j.1432-1033.1995.tb20202.x

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Glucose-induced translocation of protein kinase C isoforms in rat-1 fibroblasts is paralleled by inhibition of the insulin receptor tyrosine kinase

Autor: J Mushack, Hans-U. Häring, E Seffer, Stefanie Tippmer, L Mosthaf, Monika Kellerer, L Berti, K Seedorf, G Kroder

Publikováno v: Journal of Biological Chemistry. 269:3381-3386

Rat-1 fibroblasts stably overexpressing high levels of human insulin receptor were used as a model system to study the effects of hyperglycemia on insulin receptor tyrosine kinase (IRK) activity and protein kinase C (PKC) translocation in parallel in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::23ed208a278dab7c64c3f25c9eb7e408
https://doi.org/10.1016/s0021-9258(17)41873-4

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Stimulation of phospholipase C activity by insulin is mediated by both isotypes of the human insulin receptor

Autor: Axel Ullrich, E Seffer, Monika Kellerer, Fausto Machicao, Hans-Ulrich Häring, J. Mushack

Publikováno v: Biochemical and Biophysical Research Communications. 181:566-572

The human insulin receptor exists in two isoforms, HIR-A and HIR-B. We studied whether both insulin receptor isotypes are able to mediate an insulin signal to phospholipase C. Plasma membranes were prepared from rat-1 fibroblasts transfected either w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a1270ea191ea3d89d53aa857eba2827
https://doi.org/10.1016/0006-291x(91)91227-4

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Protein kinase C (PKC) epsilon enhances the inhibitory effect of TNF alpha on insulin signaling in HEK293 cells

Autor: Monika Kellerer, J. Mushack, Harald Mischak, Hans-Ulrich Häring

Publikováno v: FEBS letters. 418(1-2)

Recently we have shown that PKC beta1 and beta2 are able to inhibit the tyrosine kinase activity of the human insulin receptor (HIR). Now we have investigated whether a distinct PKC isoform might be involved in the inhibitory effect of TNF alpha on i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a825e6a9e941d4ffb28dae8cdccd71
https://pubmed.ncbi.nlm.nih.gov/9414108

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Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways

Autor: J. Mushack, Hans-Ulrich Häring, Monika Kellerer, E. Metzinger, Edison Capp, M. Koch

Publikováno v: Diabetologia. 40(11)

We have recently shown that leptin mimicks insulin effects on glucose transport and glycogen synthesis through a phosphatidylinositol-3 (PI) kinase dependent pathway in C2C12 myotubes. The aim of the present study was to identify the signalling path

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f77869b65f95eb05640fac1eb506133a
https://pubmed.ncbi.nlm.nih.gov/9389430

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