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Akademický článek

Cycloalkane-modified amphiphilic polymers provide direct extraction of membrane proteins for CryoEM analysis

Autor: Anna J. Higgins, Alex J. Flynn, Anaïs Marconnet, Laura J. Musgrove, Vincent L. G. Postis, Jonathan D. Lippiat, Chun-wa Chung, Tom Ceska, Manuela Zoonens, Frank Sobott, Stephen P. Muench

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)

Higgins et al. present a cycloalkane-modified amphiphilic polymer that can provide direct extraction of membrane proteins for Cryo-EM analysis. They show its utility by extracting and solving the structure of AcrB to a high resolution of 3.2 Å by si

Externí odkaz: https://doaj.org/article/1c131cd75303428686e3487d6389ace3

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BRCA1-BARD1 combines multiple chromatin recognition modules to bridge nascent nucleosomes

Autor: Hayden Burdett, Martina Foglizzo, Laura J. Musgrove, Dhananjay Kumar, Gillian Clifford, Lisa J. Campbell, George R. Heath, Elton Zeqiraj, Marcus D. Wilson

Chromatin association of the BRCA1-BARD1 heterodimer is critical to promote homologous recombination repair of DNA double-strand breaks (DSBs) in S/G2. How the BRCA1-BARD1 complex interacts with chromatin that contains both damage induced histone H2A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93e34e10779b1e9b60372afd5412b072
https://doi.org/10.1101/2023.03.28.533771

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Cycloalkane-modified amphiphilic polymers provide direct extraction of membrane proteins for CryoEM analysis

Autor: Frank Sobott, Laura J. Musgrove, Anna J. Higgins, Chun-wa Chung, Alex J. Flynn, Stephen P. Muench, Tom Ceska, Jonathan D. Lippiat, Manuela Zoonens, Anaïs Marconnet, Vincent L. G. Postis

Membrane proteins are essential for cellular growth, signalling and homeostasis, making up a large proportion of therapeutic targets. However, the necessity for a solubilising agent to extract them from the membrane creates challenges in their struct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17aee626adaa24e1c6e4bda7be361131
https://doi.org/10.21203/rs.3.rs-131488/v1

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Pollinator monitoring more than pays for itself

Publikováno v: Journal of Applied Ecology
Journal of Applied Ecology, Wiley, 2021, 58 (1), pp.44-57. ⟨10.1111/1365-2664.13755⟩

International audience; This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.1. Resilient pollination

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952f3b1063700a7686fc1d62f18f583b
http://doi.org/10.1111/1365-2664.13755

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Prevalence and predictors of spontaneous bacterial peritonitis due to ceftriaxone-resistant organisms at a large tertiary centre in the USA

Autor: Rachel J. Musgrove, Kevin W. Garey, Todd M. Lasco, Raymond Yau, Nicholas D. Beyda, Amelia K. Sofjan, Hannah Palmer Russo, Alejandro Restrepo

Publikováno v: Journal of Global Antimicrobial Resistance. 15:41-47

Objectives The epidemiology of spontaneous bacterial peritonitis (SBP) due to ceftriaxone-resistant organisms has not been well studied in the USA. The primary objective of this study was to assess the prevalence and predictors of ceftriaxone-resista

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af5a5bdec4a967db6cf1f68a59d82197
https://doi.org/10.1016/j.jgar.2018.05.015

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Overcoming the challenges of public data archiving for citizen science biodiversity recording and monitoring schemes

Autor: Simon Gillings, Aleksi Lehikoinen, Robert A. Robinson, Andy J. Musgrove, Stephen R. Baillie, Kevin J. Walker, James W. Pearce-Higgins, Katherine L. Boughey, Ruud P. B. Foppen, Tom Hunt, Richard D. Gregory, David B. Roy, Gavin M. Siriwardena, Jeremy D. Wilson, Frédéric Jiguet, Nigel A. D. Bourn

Publikováno v: Journal of Applied Ecology, 2018, 1-8
Journal of Applied Ecology, 2018, pp. 1-8

1. Public data archiving (PDA) is widely advocated as a means of achieving open data standards, leading to improved data preservation, increased scientific reproducibility, and transparency, as well as additional data use. 2. Public data archiving wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5d1db856d06563ac3a0f97d759e6b79
https://doi.org/10.1111/1365-2664.13180

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Comparison of Pharmacist-Directed Management of Multiplex PCR Blood Culture Results with Conventional Microbiology Methods on Effective and Optimal Therapy within a Community Hospital

Autor: Geneen M Gibson, Sabrina R. Croft, Christopher M. Bland, Parks W. Miller, Rachel J. Musgrove, Henry N. Young, Emilee M. Robertson, David R. Allen, Allison M. Porter, R. Ellen Gayheart

Publikováno v: Antimicrobial Agents and Chemotherapy. 63

Multiplex PCR combined with a pharmacist-driven reporting protocol was compared to the standard of care within a community hospital to evaluate initial changes after notification of a positive blood culture. The intervention group demonstrated decrea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a7ee64b33d73b0df3272c02bf53aa8
https://doi.org/10.1128/aac.01575-18

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Akademický článek

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Long-term changes in the migration phenology of UK breeding birds detected by large-scale citizen science recording schemes

Autor: James W. Pearce-Higgins, Stephen R. Baillie, Simon Gillings, Andy J. Musgrove, Stuart E. Newson, Mark J. Grantham, Philip W. Atkinson, Nick J. Moran, Ryan Miller

Publikováno v: Ibis. 158:481-495

The timing of migration is one of the key life-history parameters of migratory birds. It is expected to be under strong selection, to be sensitive to changing environmental conditions and to have implications for population dynamics. However, most ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a40716aae13fe5a36b4524b44d096507
https://doi.org/10.1111/ibi.12367

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