Zobrazeno 1 - 10
of 173
pro vyhledávání: '"J Mummery"'
Autor:
Roger M. Lane, Taher Darreh-Shori, Candice Junge, Dan Li, Qingqing Yang, Amanda L. Edwards, Danielle L. Graham, Katrina Moore, Catherine J. Mummery
Publikováno v:
BMC Neurology, Vol 24, Iss 1, Pp 1-16 (2024)
Abstract Background The authors sought to examine the impact of the K-variant of butyrylcholinesterase (BCHE-K) carrier status on age-at-diagnosis of Alzheimer disease (AD) in APOE4 carriers. Methods Patients aged 50–74 years with cerebrospinal flu
Externí odkaz:
https://doaj.org/article/730fc122897643a1aee9109ee499d3ab
Autor:
Catherine J Mummery, Henrik Zetterberg, Rury R Holman, Brian Tom, Ivan Koychev, Peter Hellyer, Amanda I Adler, Elizabeth Coulthard, Benjamin R Underwood, Adam Hampshire, Charles Marshall, Paul Edison, Joanne E Milton, Joe Butchart, Francesca Cormack
Publikováno v:
BMJ Open, Vol 14, Iss 6 (2024)
Introduction Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), currently marketed for type 2 diabetes and obesity, may offer novel mechanisms to delay or prevent neurotoxicity associated with Alzheimer’s disease (AD). The impact of semaglutide
Externí odkaz:
https://doaj.org/article/16420298a11d448f9195b369edad8d96
Autor:
Janice M. Ranson, Timothy Rittman, Shabina Hayat, Carol Brayne, Frank Jessen, Kaj Blennow, Cornelia van Duijn, Frederik Barkhof, Eugene Tang, Catherine J. Mummery, Blossom C. M. Stephan, Daniele Altomare, Giovanni B. Frisoni, Federica Ribaldi, José Luis Molinuevo, Philip Scheltens, David J. Llewellyn, on behalf of the European Task Force for Brain Health Services
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-12 (2021)
Abstract We envisage the development of new Brain Health Services to achieve primary and secondary dementia prevention. These services will complement existing memory clinics by targeting cognitively unimpaired individuals, where the focus is on risk
Externí odkaz:
https://doaj.org/article/b32cfaafd9ce4f9999e42323b5763f5f
Autor:
Andrew J. Aschenbrenner, Jason Hassenstab, Guoqiao Wang, Yan Li, Chengjie Xiong, Eric McDade, David B. Clifford, Stephen Salloway, Martin Farlow, Roy Yaari, Eden Y. J. Cheng, Karen C. Holdridge, Catherine J. Mummery, Colin L. Masters, Ging-Yuek Hsiung, Ghulam Surti, Gregory S. Day, Sandra Weintraub, Lawrence S. Honig, James E. Galvin, John M. Ringman, William S. Brooks, Nick C. Fox, Peter J. Snyder, Kazushi Suzuki, Hiroyuki Shimada, Susanne Gräber, Randall J. Bateman
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Demonstrating a slowing in the rate of cognitive decline is a common outcome measure in clinical trials in Alzheimer’s disease (AD). Selection of cognitive endpoints typically includes modeling candidate outcome measures in the many, richly phenoty
Externí odkaz:
https://doaj.org/article/729c320574be4f4a868a3bad97db96d9
Autor:
Laura A. Benjamin, Ross W. Paterson, Rachel Moll, Charis Pericleous, Rachel Brown, Puja R. Mehta, Dilan Athauda, Oliver J. Ziff, Judith Heaney, Anna M. Checkley, Catherine F. Houlihan, Michael Chou, Amanda J. Heslegrave, Arvind Chandratheva, Benedict D. Michael, Kaj Blennow, Vinojini Vivekanandam, Alexander Foulkes, Catherine J. Mummery, Michael P. Lunn, Stephen Keddie, Moira J. Spyer, Tom Mckinnon, Melanie Hart, Francesco Carletti, Hans Rolf Jäger, Hadi Manji, Michael S. Zandi, David J. Werring, Eleni Nastouli, Robert Simister, Tom Solomon, Henrik Zetterberg, Jonathan M. Schott, Hannah Cohen, Maria Efthymiou
Publikováno v:
EClinicalMedicine, Vol 39, Iss , Pp 101070- (2021)
Background: A high prevalence of antiphospholipid antibodies has been reported in case series of patients with neurological manifestations and COVID-19; however, the pathogenicity of antiphospholipid antibodies in COVID-19 neurology remains unclear.
Externí odkaz:
https://doaj.org/article/3eef6c9f06c243ceb51ecb95ba2fa15f
Autor:
Catherine J. Mummery, Anne Börjesson-Hanson, Daniel J. Blackburn, Everard G. B. Vijverberg, Peter Paul De Deyn, Simon Ducharme, Michael Jonsson, Anja Schneider, Juha O. Rinne, Albert C. Ludolph, Ralf Bodenschatz, Holly Kordasiewicz, Eric E. Swayze, Bethany Fitzsimmons, Laurence Mignon, Katrina M. Moore, Chris Yun, Tiffany Baumann, Dan Li, Daniel A. Norris, Rebecca Crean, Danielle L. Graham, Ellen Huang, Elena Ratti, C. Frank Bennett, Candice Junge, Roger M. Lane
Publikováno v:
Nature medicine 29(6), 1437-1447 (2023). doi:10.1038/s41591-023-02326-3
Mummery, C J, Börjesson-Hanson, A, Blackburn, D J, Vijverberg, E G B, de Deyn, P P, Ducharme, S, Jonsson, M, Schneider, A, Rinne, J O, Ludolph, A C, Bodenschatz, R, Kordasiewicz, H, Swayze, E E, Fitzsimmons, B, Mignon, L, Moore, K M, Yun, C, Baumann, T, Li, D, Norris, D A, Crean, R, Graham, D L, Huang, E, Ratti, E, Bennett, C F, Junge, C & Lane, R M 2023, ' Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease : a phase 1b, randomized, placebo-controlled trial ', Nature Medicine, vol. 29, no. 6, pp. 1437-1447 . https://doi.org/10.1038/s41591-023-02326-3
Nature Medicine. Nature Publishing Group
Nature Medicine, 29, 1437-1447. Nature Publishing Group
Mummery, C J, Börjesson-Hanson, A, Blackburn, D J, Vijverberg, E G B, de Deyn, P P, Ducharme, S, Jonsson, M, Schneider, A, Rinne, J O, Ludolph, A C, Bodenschatz, R, Kordasiewicz, H, Swayze, E E, Fitzsimmons, B, Mignon, L, Moore, K M, Yun, C, Baumann, T, Li, D, Norris, D A, Crean, R, Graham, D L, Huang, E, Ratti, E, Bennett, C F, Junge, C & Lane, R M 2023, ' Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease : a phase 1b, randomized, placebo-controlled trial ', Nature Medicine, vol. 29, no. 6, pp. 1437-1447 . https://doi.org/10.1038/s41591-023-02326-3
Nature Medicine. Nature Publishing Group
Nature Medicine, 29, 1437-1447. Nature Publishing Group
Tau plays a key role in Alzheimer’s disease (AD) pathophysiology, and accumulating evidence suggests that lowering tau may reduce this pathology. We sought to inhibit MAPT expression with a tau-targeting antisense oligonucleotide (MAPTRx) and reduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a4826e86379fe0686cd40f5d60108ba
https://doi.org/10.1038/s41591-023-02326-3
https://doi.org/10.1038/s41591-023-02326-3
Autor:
Ross W. Paterson, Catherine F. Slattery, Teresa Poole, Jennifer M. Nicholas, Nadia K. Magdalinou, Jamie Toombs, Miles D. Chapman, Michael P. Lunn, Amanda J. Heslegrave, Martha S Foiani, Philip S. J. Weston, Ashvini Keshavan, Jonathan D. Rohrer, Martin N. Rossor, Jason D. Warren, Catherine J. Mummery, Kaj Blennow, Nick C. Fox, Henrik Zetterberg, Jonathan M. Schott
Publikováno v:
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-11 (2018)
Abstract Background Cerebrospinal fluid (CSF) biomarkers are increasingly being used to support a diagnosis of Alzheimer’s disease (AD). Their clinical utility for differentiating AD from non-AD neurodegenerative dementias, such as dementia with Le
Externí odkaz:
https://doaj.org/article/cd0b740c050b4d6384bd565c2c72b223
Autor:
Charles R. Marshall, Chris J. D. Hardy, Lucy L. Russell, Camilla N. Clark, Rebecca L. Bond, Katrina M. Dick, Emilie V. Brotherhood, Cath J. Mummery, Jonathan M. Schott, Jonathan D. Rohrer, James M. Kilner, Jason D. Warren
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract Automatic motor mimicry is essential to the normal processing of perceived emotion, and disrupted automatic imitation might underpin socio-emotional deficits in neurodegenerative diseases, particularly the frontotemporal dementias. However,
Externí odkaz:
https://doaj.org/article/affe7645504d492b9b80b54899f603aa
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Autor:
Sanjay Budhdeo, Anderson Rodrigues Brandão de Paiva, Charles Wade, Laura Cardia Gomes Lopes, Bruno Della-Ripa, Indran Davagnanam, Leandro Lucato, Catherine J. Mummery, Fernando Kok, Henry Houlden, David J. Werring, David S. Lynch
Publikováno v:
Journal of Neurology. 269:6673-6677
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::420197dc99d40402eea8bb11873cf590
https://doi.org/10.1007/s00415-022-11302-9
https://doi.org/10.1007/s00415-022-11302-9