Zobrazeno 1 - 10
of 346
pro vyhledávání: '"J Mole"'
Autor:
Alastair J. Hayes, Xiaozhong Zheng, James O’Kelly, Lucile P.A. Neyton, Natalia A. Bochkina, Iain Uings, John Liddle, J. Kenneth Baillie, George Just, Margaret Binnie, Natalie Z.M. Homer, Toby B.J. Murray, James Baily, Kris McGuire, Christos Skouras, O. James Garden, Scott P. Webster, John P. Iredale, Sarah E.M. Howie, Damian J. Mole
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112763- (2023)
Summary: Kynurenine monooxygenase (KMO) blockade protects against multiple organ failure caused by acute pancreatitis (AP), but the link between KMO and systemic inflammation has eluded discovery until now. Here, we show that the KMO product 3-hydrox
Externí odkaz:
https://doaj.org/article/60fcd40d031a4ce4a162a97e4de568a3
Publikováno v:
Heliyon, Vol 9, Iss 4, Pp e15335- (2023)
Circadian rhythms are responsible for governing various physiological processes, including hormone secretion, immune responses, metabolism, and the sleep/wake cycle. In critical illnesses such as acute pancreatitis (AP), circadian rhythms can become
Externí odkaz:
https://doaj.org/article/24366f4cc77846fab13ef1bf28ba5f74
Autor:
Noelle J. Molé
Psychological harassment at work, or'mobbing,'has become a significant public policy issue in Italy and elsewhere in Europe. Mobbing has given rise to specialized counseling clinics, a new field of professional expertise, and new labor laws. For Noel
Autor:
Marc‐Olivier Deguise, Giovanni Baranello, Chiara Mastella, Ariane Beauvais, Jean Michaud, Alessandro Leone, Ramona De Amicis, Alberto Battezzati, Christopher Dunham, Kathryn Selby, Jodi Warman Chardon, Hugh J. McMillan, Yu‐Ting Huang, Natalie L. Courtney, Alannah J. Mole, Sabrina Kubinski, Peter Claus, Lyndsay M. Murray, Melissa Bowerman, Thomas H. Gillingwater, Simona Bertoli, Simon H. Parson, Rashmi Kothary
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 6, Iss 8, Pp 1519-1532 (2019)
Abstract Objective Spinal muscular atrophy (SMA) is an inherited neuromuscular disorder leading to paralysis and subsequent death in young children. Initially considered a motor neuron disease, extra‐neuronal involvement is increasingly recognized.
Externí odkaz:
https://doaj.org/article/fc27db022435433fb87c7d2bb5016994
Autor:
Xiaozhong Zheng, Ailiang Zhang, Margaret Binnie, Kris McGuire, Scott P. Webster, Jeremy Hughes, Sarah E. M. Howie, Damian J. Mole
Publikováno v:
Experimental and Molecular Medicine, Vol 51, Iss 2, Pp 1-14 (2019)
Kidney disease: drug target for acute injury following reperfusion Inhibition of a metabolic enzyme linked to inflammation could be a novel treatment approach for sudden kidney failure following a “reperfusion” injury caused by blood flow returni
Externí odkaz:
https://doaj.org/article/ecd0d27bbf6d459ca7a317a69807af0d
Autor:
Soudabeh Rad Pour, Hiromasa Morikawa, Narsis A. Kiani, David Gomez-Cabrero, Alistair Hayes, Xiaozhong Zheng, Maria Pernemalm, Janne Lehtiö, Damian J. Mole, Johan Hansson, Hanna Eriksson, Jesper Tegnér
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Dysregulation of the kynurenine pathway has been regarded as a mechanism of tumor immune escape by the enzymatic activity of indoleamine 2, 3 dioxygenase and kynurenine production. However, the immune-modulatory properties of other kynurenine metabol
Externí odkaz:
https://doaj.org/article/a3a931a5829443e5bdad59c2b11dd4a5
Autor:
Damian J Mole, Jonathan A Fallowfield, Ahmed E Sherif, Timothy Kendall, Scott Semple, Matt Kelly, Gerard Ridgway, John J Connell, John McGonigle, Rajarshi Banerjee, J Michael Brady, Xiaozhong Zheng, Michael Hughes, Lucile Neyton, Joanne McClintock, Garry Tucker, Hilary Nailon, Dilip Patel, Anthony Wackett, Michelle Steven, Fenella Welsh, Myrddin Rees, HepaT1ca Study Group
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0238568 (2020)
The risk of poor post-operative outcome and the benefits of surgical resection as a curative therapy require careful assessment by the clinical care team for patients with primary and secondary liver cancer. Advances in surgical techniques have impro
Externí odkaz:
https://doaj.org/article/efe9d90ff055482e9e64951c38de830b
Autor:
Dolors Puigoriol-Illamola, Júlia Companys-Alemany, Kris McGuire, Natalie Z. M. Homer, Rosana Leiva, Santiago Vázquez, Damian J. Mole, Christian Griñán-Ferré, Mercè Pallàs
Publikováno v:
Pharmaceuticals, Vol 14, Iss 10, p 1040 (2021)
Impaired glucocorticoid (GC) signaling is a significant factor in aging, stress, and neurodegenerative diseases such as Alzheimer’s disease. Therefore, the study of GC-mediated stress responses to chronic moderately stressful situations, which occu
Externí odkaz:
https://doaj.org/article/215b208ba57149ba94865e604599c448
Autor:
Jonathan P. Hutchinson, Paul Rowland, Mark R. D. Taylor, Erica M. Christodoulou, Carl Haslam, Clare I. Hobbs, Duncan S. Holmes, Paul Homes, John Liddle, Damian J. Mole, Iain Uings, Ann L. Walker, Scott P. Webster, Christopher G. Mowat, Chun-wa Chung
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Kynurenine-3-monooxygenase (KMO) is an emerging clinical target for treatment of neurodegenerative diseases and acute pancreatitis. Here, the authors report potent inhibitors that bind KMO in an unexpected conformation, offering structural and mechan
Externí odkaz:
https://doaj.org/article/6a2d1e05cbf54050aa6e26f4834e4b9a
Autor:
J. Mole-Bajer
Publikováno v:
Acta Societatis Botanicorum Poloniae, Vol 22, Iss 4, Pp 811-828 (2017)
Externí odkaz:
https://doaj.org/article/5b1acc1f4a3c41b7b1579b7442d593d8