Výsledky vyhledávání

Immune response against serial infusion of factor VIII antigen through an implantable venous-access device system in haemophilia A mice

Autor: S, Madoiwa, E, Kobayashi, Y, Kashiwakura, A, Sakata, A, Yasumoto, T, Ohmori, J, Mimuro, Y, Sakata

Publikováno v: Haemophilia : the official journal of the World Federation of Hemophilia. 18(3)

Haemophilia A is a life long bleeding disorder caused by an inherited deficiency of factor VIII (FVIII). About 30% of haemophilia A patients develop neutralizing antibodies as a consequence of treatment with FVIII concentrates. Immune tolerance proto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fd880f631d6ded72adf390f796b94e23
https://pubmed.ncbi.nlm.nih.gov/22044430

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Interactions between type 1 plasminogen activator inhibitor, extracellular matrix and vitronectin

Autor: Raymond R. Schleef, J. Mimuro, Dietmar Seiffert, David J. Loskutoff

Publikováno v: Cell Differentiation and Development. 32:287-292

Regulation of plasminogen activation is a key process in controlling proteolytic events in the extracellular matrix (ECM) and this regulation is achieved through the action of specific plasminogen activator (PA) inhibitors (PAIs). Type I PAI (PAI-1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f355a7c19a11098dd3dc3fc3cdb0feb1
https://doi.org/10.1016/0922-3371(90)90041-t

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Detection of vitronectin by ligand blotting with type 1 plasminogen activator inhibitor

Autor: J. Mimuro, David J. Loskutoff, Dietmar Seiffert

Publikováno v: Fibrinolysis. 4:197-202

Ligand blotting procedures were developed for the detection of type 1 plasminogen activator inhibitor (PAI-1) binding protein(s) (BPs) transferred to nitrocellulose sheets after sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). Pu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5798321e37ced9da0753db3cee47a740
https://doi.org/10.1016/0268-9499(90)90014-b

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The majority of type 1 plasminogen activator inhibitor associated with cultured human endothelial cells is located under the cells and is accessible to solution-phase tissue-type plasminogen activator

Autor: J. Mimuro, David J. Loskutoff, Raymond R. Schleef, Eileen Dunne, T J Podor

Publikováno v: The Journal of Cell Biology

The interactions between exogenously added tissue-type plasminogen activator (t-PA) and the active form of type 1 plasminogen activator inhibitor (PAI-1) produced by and present in cultured human umbilical vein endothelial cells (HUVECs) were investi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4fba17a873789b9fc40b16cb006ca11
https://doi.org/10.1083/jcb.110.1.155

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End-linked homodimers in fibrinogen Osaka VI with a B beta-chain extension lead to fragile clot structure

Autor: T, Sugo, C, Nakamikawa, N, Yoshida, K, Niwa, M, Sameshima, J, Mimuro, J W, Weisel, A, Nagita, M, Matsuda

Publikováno v: Blood. 96(12)

The authors have identified a 12-residue carboxyl-terminal extension of Lys-Ser-Pro-Met-Arg-Arg-Phe-Leu-Leu-Phe-Cys-Met in a dysfibrinogen derived from a woman heterozygotic for this abnormality and associated with severe bleeding. This extension is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0c6ac268ffb0b5274288df33ca40c74e
https://pubmed.ncbi.nlm.nih.gov/11090060

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Fibrinogen Niigata with impaired fibrin assembly: an inherited dysfibrinogen with a Bbeta Asn-160 to Ser substitution associated with extra glycosylation at Bbeta Asn-158

Autor: T, Sugo, C, Nakamikawa, H, Takano, J, Mimuro, S, Yamaguchi, M W, Mosesson, D A, Meh, J P, DiOrio, N, Takahashi, H, Takahashi, K, Nagai, M, Matsuda

Publikováno v: Blood. 94(11)

A novel BbetaAsn-160 (TAA) to Ser (TGA) substitution has been identified in fibrinogen Niigata derived from a 64-year-old asymptomatic woman, who is heterozygotic for this abnormality. The mutation creates an Asn-X-Ser-type glycosylation sequence, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eed7567c6bcbbe65a68ba9a675045ead
https://pubmed.ncbi.nlm.nih.gov/10572095

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A new type of Ser substitution for gamma Arg-275 in fibrinogen Kamogawa I characterized by impaired fibrin assembly

Autor: J, Mimuro, Y, Kawata, K, Niwa, S, Muramatsu, S, Madoiwa, H, Takano, T, Sugo, Y, Sakata, T, Sugimoto, K, Nose, M, Matsuda

Publikováno v: Thrombosis and haemostasis. 81(6)

A new type of substitution, Arg to Ser at gamma275, has been found in a heterozygous dysfibrinogen derived from a 23-year-old woman with no major bleeding or thrombosis. By sequence analyses of the affected gamma-chain and its gene. we found a single

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9875b1401eada72e8f6220c3995c0670
https://pubmed.ncbi.nlm.nih.gov/10404772

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A gamma Gly-268 to Glu substitution is responsible for impaired fibrin assembly in a homozygous dysfibrinogen Kurashiki I

Autor: K, Niwa, M, Takebe, T, Sugo, Y, Kawata, J, Mimuro, S, Asakura, Y, Sakata, J, Mizushima, A, Maeda, H, Endo, M, Matsuda

Publikováno v: Blood. 87(11)

A new type of gamma Gly-268 (GGA) to Glu (GAA) substitution has been identified in a homozygous dysfibrinogen by analyses of the affected polypeptide and its encoding gene derived from a 58 year-old man manifesting no major bleeding or thrombosis. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::db15115ccc61cd794f00ff630678cf09
https://pubmed.ncbi.nlm.nih.gov/8639838

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