Zobrazeno 1 - 10
of 370
pro vyhledávání: '"J Michael McIntosh"'
Autor:
Santhosh Sethuramanujam, Akihiro Matsumoto, Geoff deRosenroll, Benjamin Murphy-Baum, J Michael McIntosh, Miao Jing, Yulong Li, David Berson, Keisuke Yonehara, Gautam B. Awatramani
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Cholinergic neurons may transmit information via fast synaptic, point-to-point signaling or diffuse, slow extra-synaptic signaling. The authors show that ACh from a single vesicle triggers synchronous miniature currents in two neurons, showing that A
Externí odkaz:
https://doaj.org/article/5b4feb7a3c6b447298dcba902c79f327
Altered nicotine reward-associated behavior following α4 nAChR subunit deletion in ventral midbrain.
Autor:
Can Peng, Staci E Engle, Yijin Yan, Marcus M Weera, Jennifer N Berry, Matthew C Arvin, Guiqing Zhao, J Michael McIntosh, Julia A Chester, Ryan M Drenan
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0182142 (2017)
Nicotinic acetylcholine receptors containing α4 subunits (α4β2* nAChRs) are critical for nicotinic cholinergic transmission and the addictive action of nicotine. To identify specific activities of these receptors in the adult mouse brain, we coupl
Externí odkaz:
https://doaj.org/article/5a4fdee2b9f645bd89d000874dc2acce
Autor:
Alicia Hernández-Vivanco, Arik J Hone, Mick L Scadden, Beatriz Carmona-Hidalgo, J Michael McIntosh, Almudena Albillos
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94142 (2014)
Nicotinic acetylcholine receptors (nAChRs) that contain α6 and β4 subunits have been demonstrated functionally in human adrenal chromaffin cells, rat dorsal root ganglion neurons, and on noradrenergic terminals in the hippocampus of adolescent mice
Externí odkaz:
https://doaj.org/article/382a78ac57c8414f9c6b09511bb074ad
Autor:
Sulan Luo, Sean Christensen, Dongting Zhangsun, Yong Wu, Yuanyan Hu, Xiaopeng Zhu, Sandeep Chhabra, Raymond S Norton, J Michael McIntosh
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54648 (2013)
Conotoxins (CTxs) selectively target a range of ion channels and receptors, making them widely used tools for probing nervous system function. Conotoxins have been previously grouped into superfamilies according to signal sequence and into families b
Externí odkaz:
https://doaj.org/article/071262f77a984f7b9d57050e454cfa8c
Autor:
Olena Filchakova, J Michael McIntosh
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64655 (2013)
Nicotinic acetylcholine receptors (nAChRs) containing the α9 subunit are expressed in a wide variety of non-neuronal tissues ranging from immune cells to breast carcinomas. The α9 subunit is able to assemble into a functional homomeric nAChR and al
Externí odkaz:
https://doaj.org/article/bba9fe3d74cf47e282e631e40695f947
Autor:
Sravanthi Gundavarapu, Neerad C Mishra, Shashi P Singh, Raymond J Langley, Ali Imran Saeed, Carol A Feghali-Bostwick, J Michael McIntosh, Julie Hutt, Ramakrishna Hegde, Shilpa Buch, Mohan L Sopori
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77160 (2013)
Lung diseases such as chronic obstructive pulmonary disease (COPD), asthma, and lung infections are major causes of morbidity and mortality among HIV-infected patients even in the era of antiretroviral therapy (ART). Many of these diseases are strong
Externí odkaz:
https://doaj.org/article/f0f2d8fa80d6449ca974fa8503dda8ec
Autor:
Jorge L. B. Neves, Cristoval Urcino, Kevin Chase, Cheryl Dowell, Arik J. Hone, David Morgenstern, Victor M. Chua, Iris Bea L. Ramiro, Julita S. Imperial, Lee S. Leavitt, Jasmine Phan, Fernando A. Fisher, Maren Watkins, Shrinivasan Raghuraman, Jortan O. Tun, Beatrix M. Ueberheide, J. Michael McIntosh, Vitor Vasconcelos, Baldomero M. Olivera, Joanna Gajewiak
Publikováno v:
Marine Drugs, Vol 22, Iss 3, p 118 (2024)
The venom of cone snails has been proven to be a rich source of bioactive peptides that target a variety of ion channels and receptors. α-Conotoxins (αCtx) interact with nicotinic acetylcholine receptors (nAChRs) and are powerful tools for investig
Externí odkaz:
https://doaj.org/article/eb10793f322b4e929d26fb3a31f6499e
Autor:
Huanbai Wang, Xiaodan Li, Yamin Qiao, Meiting Wang, Wen Wang, J. Michael McIntosh, Dongting Zhangsun, Sulan Luo
Publikováno v:
Marine Drugs, Vol 22, Iss 1, p 49 (2024)
Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting painful neuropathy that occurs commonly during cancer management, which often leads to the discontinuation of medication. Previous studies suggest that the α9α10 nicotinic acetylc
Externí odkaz:
https://doaj.org/article/ba09a33718214b9dbeb5fce718ed0258
Autor:
Arik J. Hone, J. Michael McIntosh
Publikováno v:
Pharmacological Research, Vol 190, Iss , Pp 106715- (2023)
Nicotinic acetylcholine receptors (nAChRs) have been historically defined as ligand-gated ion channels and function as such in the central and peripheral nervous systems. Recently, however, non-ionic signaling mechanisms via nAChRs have been demonstr
Externí odkaz:
https://doaj.org/article/e3dca2c0dcc244888c3c7ab7f37cf7d2
Autor:
Arik J. Hone, J. Michael McIntosh
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
In the nervous system, nicotinic acetylcholine receptors (nAChRs) rapidly transduce a chemical signal into one that is electrical via ligand-gated ion flux through the central channel of the receptor. However, some nAChR subunits are expressed by non
Externí odkaz:
https://doaj.org/article/13e4de7b005b4f66b4ce7b2e24b69f0e