Zobrazeno 1 - 10
of 527
pro vyhledávání: '"J Michael McIntosh"'
Autor:
Jorge L. B. Neves, Cristoval Urcino, Kevin Chase, Cheryl Dowell, Arik J. Hone, David Morgenstern, Victor M. Chua, Iris Bea L. Ramiro, Julita S. Imperial, Lee S. Leavitt, Jasmine Phan, Fernando A. Fisher, Maren Watkins, Shrinivasan Raghuraman, Jortan O. Tun, Beatrix M. Ueberheide, J. Michael McIntosh, Vitor Vasconcelos, Baldomero M. Olivera, Joanna Gajewiak
Publikováno v:
Marine Drugs, Vol 22, Iss 3, p 118 (2024)
The venom of cone snails has been proven to be a rich source of bioactive peptides that target a variety of ion channels and receptors. α-Conotoxins (αCtx) interact with nicotinic acetylcholine receptors (nAChRs) and are powerful tools for investig
Externí odkaz:
https://doaj.org/article/eb10793f322b4e929d26fb3a31f6499e
Autor:
Huanbai Wang, Xiaodan Li, Yamin Qiao, Meiting Wang, Wen Wang, J. Michael McIntosh, Dongting Zhangsun, Sulan Luo
Publikováno v:
Marine Drugs, Vol 22, Iss 1, p 49 (2024)
Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting painful neuropathy that occurs commonly during cancer management, which often leads to the discontinuation of medication. Previous studies suggest that the α9α10 nicotinic acetylc
Externí odkaz:
https://doaj.org/article/ba09a33718214b9dbeb5fce718ed0258
Autor:
Arik J. Hone, J. Michael McIntosh
Publikováno v:
Pharmacological Research, Vol 190, Iss , Pp 106715- (2023)
Nicotinic acetylcholine receptors (nAChRs) have been historically defined as ligand-gated ion channels and function as such in the central and peripheral nervous systems. Recently, however, non-ionic signaling mechanisms via nAChRs have been demonstr
Externí odkaz:
https://doaj.org/article/e3dca2c0dcc244888c3c7ab7f37cf7d2
Autor:
Fabian Edinger, Christoph Schmitt, Christian Koch, J. Michael McIntosh, Sabina Janciauskiene, Melanie Markmann, Michael Sander, Winfried Padberg, Veronika Grau
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Extracorporeal membrane oxygenation (ECMO) is a life-saving intervention for patients suffering from respiratory or cardiac failure. The ECMO-associated morbidity and mortality depends to a large extent on the underlying disease and is often
Externí odkaz:
https://doaj.org/article/44e41d8a7d1447bc9dba3cdba4e8e8d2
Autor:
Arik J. Hone, J. Michael McIntosh
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
In the nervous system, nicotinic acetylcholine receptors (nAChRs) rapidly transduce a chemical signal into one that is electrical via ligand-gated ion flux through the central channel of the receptor. However, some nAChR subunits are expressed by non
Externí odkaz:
https://doaj.org/article/13e4de7b005b4f66b4ce7b2e24b69f0e
Autor:
Santhosh Sethuramanujam, Akihiro Matsumoto, Geoff deRosenroll, Benjamin Murphy-Baum, J Michael McIntosh, Miao Jing, Yulong Li, David Berson, Keisuke Yonehara, Gautam B. Awatramani
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Cholinergic neurons may transmit information via fast synaptic, point-to-point signaling or diffuse, slow extra-synaptic signaling. The authors show that ACh from a single vesicle triggers synchronous miniature currents in two neurons, showing that A
Externí odkaz:
https://doaj.org/article/5b4feb7a3c6b447298dcba902c79f327
Autor:
Katrin Richter, Roger L. Papke, Clare Stokes, Danika C. Roy, Eduardo S. Espinosa, Philipp M. K. Wolf, Andreas Hecker, Juliane Liese, Vijay K. Singh, Winfried Padberg, Klaus-Dieter Schlüter, Marius Rohde, J. Michael McIntosh, Barbara J. Morley, Nicole A. Horenstein, Veronika Grau, Alain R. Simard
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Activation of nicotinic acetylcholine receptors (nAChRs) expressed by innate immune cells can attenuate pro-inflammatory responses. Silent nAChR agonists, which down-modulate inflammation but have little or no ionotropic activity, are of outstanding
Externí odkaz:
https://doaj.org/article/1f0c695d5b094b88ab15c35a1caca9c0
Autor:
Francesco Margiotta, Laura Micheli, Clara Ciampi, Carla Ghelardini, J. Michael McIntosh, Lorenzo Di Cesare Mannelli
Publikováno v:
Marine Drugs, Vol 20, Iss 12, p 773 (2022)
Conus regius is a marine venomous mollusk of the Conus genus that captures its prey by injecting a rich cocktail of bioactive disulfide bond rich peptides called conotoxins. These peptides selectively target a broad range of ion channels, membrane re
Externí odkaz:
https://doaj.org/article/82eb9b1775144173b059daeeb6e3aa2d
Publikováno v:
Cells, Vol 11, Iss 22, p 3561 (2022)
Chemotherapy-induced neuropathic pain is a debilitating and dose-limiting side effect. Oxaliplatin is a third-generation platinum and antineoplastic compound that is commonly used to treat colorectal cancer and commonly yields neuropathic side effect
Externí odkaz:
https://doaj.org/article/165c463e528e41af82b78b74428a39c5
Autor:
Fernando Fisher, Yuanyuan Zhang, Philippe F. Y. Vincent, Joanna Gajewiak, Thomas J. Gordon, Elisabeth Glowatzki, Paul Albert Fuchs, J. Michael McIntosh
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Efferent cholinergic neurons inhibit sensory hair cells of the vertebrate inner ear through the combined action of calcium-permeable α9α10-containing nicotinic acetylcholine receptors (nAChRs) and associated calcium-dependent potassium channels. Th
Externí odkaz:
https://doaj.org/article/387b50ea22dd45509aeb0bc2aefdcc6c