Zobrazeno 1 - 10
of 147
pro vyhledávání: '"J Michael McCaffery"'
Publikováno v:
eLife, Vol 4 (2015)
The conserved MICOS complex functions as a primary determinant of mitochondrial inner membrane structure. We address the organization and functional roles of MICOS and identify two independent MICOS subcomplexes: Mic27/Mic10/Mic12, whose assembly is
Externí odkaz:
https://doaj.org/article/e84e32df819649d093abfcbee86f6a02
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e53523 (2012)
Mitochondrial fission in eukaryotes is mediated by protein complexes that encircle and divide mitochondrial tubules. In budding yeast, fission requires the membrane-anchored protein Fis1 and the dynamin-related GTPase Dnm1. Dnm1 is recruited to mitoc
Externí odkaz:
https://doaj.org/article/49730680cfc94f6ab87847725e66b32c
Autor:
David Ramonet, João Paulo L Daher, Brian M Lin, Klodjan Stafa, Jaekwang Kim, Rebecca Banerjee, Marie Westerlund, Olga Pletnikova, Liliane Glauser, Lichuan Yang, Ying Liu, Deborah A Swing, M Flint Beal, Juan C Troncoso, J Michael McCaffery, Nancy A Jenkins, Neal G Copeland, Dagmar Galter, Bobby Thomas, Michael K Lee, Ted M Dawson, Valina L Dawson, Darren J Moore
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18568 (2011)
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant familial Parkinson's disease (PD) and also contribute to idiopathic PD. LRRK2 mutations represent the most common cause of PD with clinical and neurochemi
Externí odkaz:
https://doaj.org/article/01d6a4bc1a0c4047be5141533aeb099b
Autor:
Sharon Gerecht, T.S. Karin Eisinger-Mathason, Kristy Weber, Zhiyong Xia, J. Michael McCaffery, Mark Ciccaglione, Nupur Jain, Hawley Pruitt, Daniel M. Lewis
This file contains additional data including material characterization, cell phenotype and migration, mechanotransduction pathway, proteases activity, tumor mechanics and human sarcoma cell migration.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aeb55b273eac749cb3b2548d6345ef1
https://doi.org/10.1158/0008-5472.22423875.v1
https://doi.org/10.1158/0008-5472.22423875.v1
Autor:
Sharon Gerecht, T.S. Karin Eisinger-Mathason, Kristy Weber, Zhiyong Xia, J. Michael McCaffery, Mark Ciccaglione, Nupur Jain, Hawley Pruitt, Daniel M. Lewis
Upregulation of collagen matrix crosslinking directly increases its ability to relieve stress under the constant strain imposed by solid tumor, a matrix property termed stress relaxation. However, it is unknown how rapid stress relaxation in response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77a1a4408968ae2d698cc01332932bd3
https://doi.org/10.1158/0008-5472.c.6511599.v1
https://doi.org/10.1158/0008-5472.c.6511599.v1
Autor:
Pin-Chao Liao, J. Michael McCaffery, Catherine A Tsang, Liza A. Pon, Enrique J. Garcia, Jason D. Vevea, Istvan R. Boldogh, Cierra N. Sing, Gary Tan
Publikováno v:
Autophagy. 17:2363-2383
Our previous studies reveal a mechanism for lipid droplet (LD)-mediated proteostasis in the endoplasmic reticulum (ER) whereby unfolded proteins that accumulate in the ER in response to lipid imbalance-induced ER stress are removed by LDs and degrade
Autor:
J. Michael McCaffery, Steven M. Claypool, Arnab Modak, Chunyan Wang, Elizabeth Calzada, Erica Avery, Pingdewinde N. Sam, Xianlin Han, Nathan N. Alder
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Of the four separate PE biosynthetic pathways in eukaryotes, one occurs in the mitochondrial inner membrane (IM) and is executed by phosphatidylserine decarboxylase (Psd1). Deletion of Psd1 is lethal in mice and compromises mitochondrial function. We
Autor:
Enrique J, Garcia, Pin-Chao, Liao, Gary, Tan, Jason D, Vevea, Cierra N, Sing, Catherine A, Tsang, J Michael, McCaffery, Istvan R, Boldogh, Liza A, Pon
Publikováno v:
Autophagy
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Our previous studies reveal a mechanism for lipid droplet (LD)-mediated proteostasis in the endoplasmic reticulum (ER) whereby unfolded proteins that accumulate in the ER in response to lipid imbalance-induced ER stress are removed by LDs and degrade
Autor:
J. Michael McCaffery, Grigor Varuzhanyan, Mark S. Ladinsky, Rebecca Rojansky, Hsiuchen Chen, David C. Chan
Publikováno v:
Biochim Biophys Acta Gen Subj
Background Mitochondrial fission counterbalances fusion to maintain organelle morphology, but its role during development remains poorly characterized. Mammalian spermatogenesis is a complex developmental process involving several drastic changes to
Autor:
Kai Loon Chen, Shixiang Gao, Yiping Feng, Liang Mao, Xitong Liu, J. Michael McCaffery, Khanh An Huynh
Publikováno v:
Environmental Science & Technology. 51:6821-6828
Heteroaggregation of graphene oxide (GO) with nanometer- and micrometer-sized hematite colloids, which are naturally present in aquatic systems, is investigated in this study. The heteroaggregation rates between GO and hematite nanoparticles (HemNPs)