Zobrazeno 1 - 10
of 43
pro vyhledávání: '"J Michael, Ellis"'
Autor:
Steven A. Saenz, Andrea Local, Tiffany Carr, Arvind Shakya, Shivsmriti Koul, Haiqing Hu, Lisa Chourb, Justin Stedman, Jenna Malley, Laura Akullian D’Agostino, Veerabahu Shanmugasundaram, John Malona, C. Eric Schwartz, Lisa Beebe, Meghan Clements, Ganesh Rajaraman, John Cho, Lan Jiang, Alex Dubrovskiy, Matt Kreilein, Roman Shimanovich, Lawrence G. Hamann, Laure Escoubet, J. Michael Ellis
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
Retinoic acid receptor-related orphan nuclear receptor (ROR) γt is a member of the RORC nuclear hormone receptor family of transcription factors. RORγt functions as a critical regulator of thymopoiesis and immune responses. RORγt is expressed in m
Externí odkaz:
https://doaj.org/article/c77d178e9fdf4a27bb6fc2263243c22d
Autor:
David A. Candito, Vladimir Simov, Anmol Gulati, Solomon Kattar, Ryan W. Chau, Blair T. Lapointe, Joey L. Methot, Duane E. DeMong, Thomas H. Graham, Ravi Kurukulasuriya, Mitchell H. Keylor, Ling Tong, Gregori J. Morriello, John J. Acton, Barbara Pio, Weiguo Liu, Jack D. Scott, Michael J. Ardolino, Theodore A. Martinot, Matthew L. Maddess, Xin Yan, Hakan Gunaydin, Rachel L. Palte, Spencer E. McMinn, Lisa Nogle, Hongshi Yu, Ellen C. Minnihan, Charles A. Lesburg, Ping Liu, Jing Su, Laxminarayan G. Hegde, Lily Y. Moy, Janice D. Woodhouse, Robert Faltus, Tina Xiong, Paul Ciaccio, Jennifer A. Piesvaux, Karin M. Otte, Matthew E. Kennedy, David Jonathan Bennett, Erin F. DiMauro, Matthew J. Fell, Santhosh Neelamkavil, Harold B. Wood, Peter H. Fuller, J. Michael Ellis
Publikováno v:
Journal of Medicinal Chemistry. 65:16801-16817
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::365ba0e1a6a6d085b4344b637344b726
https://doi.org/10.1021/acs.jmedchem.2c01605
https://doi.org/10.1021/acs.jmedchem.2c01605
Autor:
Cristina St Pierre, Jane Guo, John D Shin, Laura W Engstrom, Hyun-Hee Lee, Alan Herbert, Laura Surdi, James Baker, Michael Salmon, Sanjiv Shah, J Michael Ellis, Hani Houshyar, Michael A Crackower, Melanie A Kleinschek, Dallas C Jones, Alexandra Hicks, Dennis M Zaller, Stephen E Alves, Ravisankar A Ramadas
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180870 (2017)
While the immune system is essential for the maintenance of the homeostasis, health and survival of humans, aberrant immune responses can lead to chronic inflammatory and autoimmune disorders. Pharmacological modulation of drug targets in the immune
Externí odkaz:
https://doaj.org/article/a511e5553a1e4c19982a055d21745012
Autor:
Frederique M. Poulet, J. Michael Ellis, Matthew E. Kennedy, Carrie G. Markgraf, Lauren M Timmins, Dianne K. Bryce, Sabu Kuruvilla, Janice D Woodhouse, Matthew J. Fell, Karin M. Otte, Christopher Ware, Laxminarayan G Hegde, Matthew L. Maddess, Paul J Ciaccio
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 377:11-19
Gain-of-function mutations in leucine-rich kinase 2 (LRRK2) are associated with increased incidence of Parkinson disease (PD); thus, pharmacological inhibition of LRRK2 kinase activity is postulated as a disease-modifying treatment of PD. Histomorpho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f51a63a6fe69d40bfa5ed39544e2dd
https://doi.org/10.1124/jpet.120.000217
https://doi.org/10.1124/jpet.120.000217
Publikováno v:
Chemical Science
This work describes an expedient access to sp3-rich nitrogen heterocycles via mild photoredox cleavage of 4-alkyl-1,4-dihydropyridines followed by cyclization of the resultant carbon-centered radicals with tethered imines.
A large proportion of
A large proportion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd588e77e0364242bfd11f27f893a1a
https://doi.org/10.1039/c9sc03429c
https://doi.org/10.1039/c9sc03429c
Optimization of brain-penetrant picolinamide derived leucine-rich repeat kinase 2 (LRRK2) inhibitors
Autor:
Blair T. Lapointe, Jack D. Scott, Xin Cindy Yan, Haiqun Tang, Janice D Woodhouse, Kaleen Konrad Childers, Robert Faltus, Erin F. DiMauro, Solomon Kattar, Charles S. Yeung, Ravi Kurukulasuriya, Vladimir Simov, Hakan Gunaydin, Anmol Gulati, Joey L. Methot, Rachel L. Palte, Ellen C. Minnihan, Greg Morriello, J. Michael Ellis, Harold B. Wood, Santhosh Neelamkavil, Karin M. Otte, Michael J. Ardolino, Barbara Pio, Ping Liu, Laxminarayan G Hegde, Matthew J. Fell, Vanessa L. Rada, Peter Fuller, Paul J Ciaccio
Publikováno v:
RSC Med Chem
The discovery of potent, kinome selective, brain penetrant LRRK2 inhibitors is the focus of extensive research seeking new, disease-modifying treatments for Parkinson's disease (PD). Herein, we describe the discovery and evolution of a picolinamide-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8d45ea7dd7adda70471298a4476afa
https://europepmc.org/articles/PMC8292993/
https://europepmc.org/articles/PMC8292993/
Autor:
Philip R. D. Murray, Geraint Davies, J. Michael Ellis, Farid W. van der Mei, Willem M. M. Bussink, Alyssa H. Antropow, Laura Akullian D’Agostino, Fedor Romanov-Michailidis, Jacob T. Edwards, Robert R. Knowles, Lawrence G. Hamann
Publikováno v:
Journal of the American Chemical Society. 143(10)
This paper describes an intermolecular cross-selective [2 + 2] photocycloaddition reaction of exocyclic arylidene oxetanes, azetidines, and cyclobutanes with simple electron-deficient alkenes. The reaction takes place under mild conditions using a co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9baabfab15f34d6ff58bf2ada9fb3002
https://pubmed.ncbi.nlm.nih.gov/33666086
https://pubmed.ncbi.nlm.nih.gov/33666086
Autor:
Shivsmriti Koul, John Malona, Lisa Beebe, Laure Escoubet, Meghan Clements, Arvind Shakya, Veerabahu Shanmugasundaram, Lan Jiang, Lawrence G. Hamann, Matt M. Kreilein, Jenna Malley, C. Eric Schwartz, Roman Shimanovich, Ganesh Rajaraman, Alex Dubrovskiy, Laura Akullian D’Agostino, Justin Stedman, Andrea Local, J. Michael Ellis, Tiffany Carr, Steven A. Saenz, Haiqing Hu, John Cho, Lisa Chourb
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE, Vol 16, Iss 11, p e0248034 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 11, p e0248034 (2021)
PLoS ONE
Retinoic acid receptor-related orphan nuclear receptor (ROR) γt is a member of the RORC nuclear hormone receptor family of transcription factors. RORγt functions as a critical regulator of thymopoiesis and immune responses. RORγt is expressed in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43fdb7715b2c933851e25206e28f0210
https://doi.org/10.1101/2021.02.19.431952
https://doi.org/10.1101/2021.02.19.431952
Autor:
Kyle F. Biegasiewicz, Claire G. Page, Lawrence G. Hamann, Kevin M. Oberg, Gregory D. Scholes, Evan J. Horn, Simon J. Cooper, Daniel G. Oblinsky, Alyssa H. Antropow, Jacob S. Dehovitz, J. Michael Ellis, Todd K. Hyster, Kurt W. Armbrust
Publikováno v:
Journal of the American Chemical Society, vol 143, iss 1
J Am Chem Soc
J Am Chem Soc
Intermolecular C-C bond-forming reactions are underdeveloped transformations in the field of biocatalysis. Here we report a photoenzymatic intermolecular hydroalkylation of olefins catalyzed by flavin-dependent 'ene'-reductases. Radical initiation oc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2453e3684efab0c71e9d3671a592869b
https://escholarship.org/uc/item/4j59h787
https://escholarship.org/uc/item/4j59h787
Autor:
Hakan Gunaydin, Scott A. Johnson, Brian R. Lahue, Blair T. Lapointe, J. Michael Ellis, Michael D. Altman, Peter Fuller
Publikováno v:
ACS Medicinal Chemistry Letters. 9:528-533
[Image: see text] Preclinical optimization of compounds toward viable drug candidates requires an integrated understanding of properties that impact predictions of the clinically efficacious dose. The importance of optimizing half-life, unbound clear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a60921a58f824cb5af8f2a1fc42b5a38
https://doi.org/10.1021/acsmedchemlett.8b00018
https://doi.org/10.1021/acsmedchemlett.8b00018