Zobrazeno 1 - 10
of 457
pro vyhledávání: '"J Melia"'
Publikováno v:
Contact, Vol 4 (2021)
Recent studies have identified the metazoan ER-resident proteins, TMEM41B and VMP1, and so structurally related VTT-domain proteins, as glycerolipid scramblases.
Externí odkaz:
https://doaj.org/article/c8a4606359e543418ee3e933b811e0e5
Autor:
Qi Shen, Qiancheng Xiong, Kaifeng Zhou, Qingzhou Feng, Longfei Liu, Taoran Tian, Chunxiang Wu, Yong Xiong, Thomas J. Melia, C. Patrick Lusk, Chenxiang Lin
Publikováno v:
Journal of the American Chemical Society. 145:1292-1300
The DNA-origami technique has enabled the engineering of transmembrane nanopores with programmable size and functionality, showing promise in building biosensors and synthetic cells. However, it remains challenging to build large (10 nm), functionali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::511277ef72e7e499a1ccac33fe82bc64
https://doi.org/10.1021/jacs.2c11226
https://doi.org/10.1021/jacs.2c11226
Autor:
Petter Holland, Helene Knævelsrud, Kristiane Søreng, Benan J. Mathai, Alf Håkon Lystad, Serhiy Pankiv, Gunnveig T. Bjørndal, Sebastian W. Schultz, Viola H. Lobert, Robin B. Chan, Bowen Zhou, Knut Liestøl, Sven R. Carlsson, Thomas J. Melia, Gilbert Di Paolo, Anne Simonsen
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Autophagy must be tightly controlled at each step of the process. Here the authors show that HS1BP3 binds phosphatidic acid (PA) at autophagosome precursors and negatively regulates autophagosome formation by modulating the activity and localization
Externí odkaz:
https://doaj.org/article/f353cc30440843249f823e8e4c1b2f7c
Autor:
Taryn J. Olivas, Yumei Wu, Shenliang Yu, Lin Luan, Peter Choi, Emily D. Guinn, Shanta Nag, Pietro V. De Camilli, Kallol Gupta, Thomas J. Melia
Publikováno v:
Journal of Cell Biology. 222
As the autophagosome forms, its membrane surface area expands rapidly, while its volume is kept low. Protein-mediated transfer of lipids from another organelle to the autophagosome likely drives this expansion, but as these lipids are only introduced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c4029f6141e26eef6d3a805a6eb055e
https://doi.org/10.1083/jcb.202208088
https://doi.org/10.1083/jcb.202208088
Akademický článek
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Autor:
Devin M Fuller, Thomas J Melia
Publikováno v:
The EMBO journalReferences.
In their recent article, Polyansky et al identify phosphatidylcholine (PC) as the most abundant lipid in the autophagosome membrane and demonstrate that eliminating de novo PC synthesis sharply impairs autophagic processing. In the absence of PC synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dabfaef0b8a14dc499834b046706bd3a
https://pubmed.ncbi.nlm.nih.gov/36478568
https://pubmed.ncbi.nlm.nih.gov/36478568
Akademický článek
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Autor:
Chenxiang Lin, Patrick D Ellis Fisher, Yong Xiong, Qiancheng Xiong, C. Patrick Lusk, Taoran Tian, Qi Shen, Thomas J. Melia
Publikováno v:
J Am Chem Soc
DNA nanotechnology provides a versatile and powerful tool to dissect the structure-function relationship of biomolecular machines like the nuclear pore complex (NPC), an enormous protein assembly that controls molecular traffic between the nucleus an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e26679ab64de3821a8c9d5a0777c6669
https://doi.org/10.1021/jacs.1c05550
https://doi.org/10.1021/jacs.1c05550
Autor:
Taryn J. Olivas, Yumei Wu, Shenliang Yu, Lin Luan, Peter Choi, Shanta Nag, Pietro De Camilli, Kallol Gupta, Thomas J. Melia
During autophagosome biogenesis, the incorporation of transmembrane proteins into the expanding phagophore is not readily observed. In addition, the membrane surface area of the organelle expands rapidly, while the volume of the autophagosome is kept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e5273c7083615c1c919165315f554bd
https://doi.org/10.1101/2022.08.16.504143
https://doi.org/10.1101/2022.08.16.504143
Autor:
Zhouping Hong, Jyoti Adlakha, Emily Guinn, Fabian Giska, Kallol Gupta, Thomas J. Melia, Karin M. Reinisch
Lipid transport proteins at membrane contact sites, where organelles are closely apposed, are critical in redistributing lipids from the endoplasmic reticulum (ER), where they are made, to other cellular membranes. Such protein mediated transfer is e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb7c732c9a2d66a16cec35644e7b08a1
https://doi.org/10.1101/2022.07.08.499339
https://doi.org/10.1101/2022.07.08.499339