Zobrazeno 1 - 10
of 96
pro vyhledávání: '"J Melhorn"'
Autor:
Mauricio D. Dorfman, Thomas Monfeuga, Susan J. Melhorn, Jenny E. Kanter, Jeremy M. Frey, Rachael D. Fasnacht, Anandhakumar Chandran, Emaad Lala, Inmaculada Velasco, Katya B. Rubinow, Thomas H. Meek, Ellen A. Schur, Karin E. Bornfeldt, Joshua P. Thaler
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 324:E461-E475
This study provides evidence that hypothalamic gliosis is a key early event through which androgen deficiency in combination with a Western-style diet might lead to cardiometabolic dysregulation in males. Furthermore, this work provides the first evi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2cf192827031d3cb0f0a3266ee84dbd
https://doi.org/10.1152/ajpendo.00059.2023
https://doi.org/10.1152/ajpendo.00059.2023
Autor:
Leticia E Sewaybricker, Alyssa Huang, Suchitra Chandrasekaran, Susan J Melhorn, Ellen A Schur
Publikováno v:
Endocr Rev
Accumulated preclinical literature demonstrates that hypothalamic inflammation and gliosis are underlying causal components of diet-induced obesity in rodent models. This review summarizes and synthesizes available translational data to better unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ca49a26747616e42ab8576665d0595f
https://doi.org/10.1210/endrev/bnac023
https://doi.org/10.1210/endrev/bnac023
Autor:
Christian L Roth, Susan J Melhorn, Mary Rosalynn B De Leon, Maya G Rowland, Clinton T Elfers, Alyssa Huang, Brian E Saelens, Ellen A Schur
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 107:2254-2266
Context Obesity interventions often result in increased motivation to eat. Objective We investigated relationships between obesity outcomes and changes in brain activation by visual food cues and hormone levels in response to obesity intervention by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c63b2124eb031b4cca719f46c2e1cfdb
https://doi.org/10.1210/clinem/dgac299
https://doi.org/10.1210/clinem/dgac299
Evidence That Hypothalamic Gliosis Is Related to Impaired Glucose Homeostasis in Adults With Obesity
Autor:
Mary Rosalynn B. De Leon, Stefan Schoen, Ellen A. Schur, Kristina M. Utzschneider, Madelaine Humphreys, Susan J. Melhorn, Jennifer L. Rosenbaum, Mary F. Webb
Publikováno v:
Diabetes Care
OBJECTIVE Preclinical research implicates hypothalamic glial cell responses in the pathogenesis of obesity and type 2 diabetes (T2D). In the current study we sought to translate such findings to humans by testing whether radiologic markers of gliosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3bda2e87f728a6e28413cb02a7481a
https://doi.org/10.2337/dc21-1535
https://doi.org/10.2337/dc21-1535
Publikováno v:
10.01 - Respiratory infections and bronchiectasis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec4b42eb29e3dbda7c2e95b24fba2910
https://doi.org/10.1183/13993003.congress-2022.4475
https://doi.org/10.1183/13993003.congress-2022.4475
Autor:
KIMBERLY M. ALONGE, MAURICIO D. DORFMAN, JARRAD M. SCARLETT, SUSAN J. MELHORN, YUANCHAO YE, SHANNON J.W. HU, KENDRA L. FRANCIS, AARUN HENDRICKSON, KATHERINE CUI, GREGORY J. MORTON, ELLEN SCHUR, JOSHUA THALER, MICHAEL W. SCHWARTZ
Publikováno v:
Diabetes. 71
Defective neurocircuit activity within the hypothalamic arcuate nucleus (ARC) , a crucial brain area for the regulation of metabolism, is implicated in obesity pathogenesis. Perineuronal nets (PNNs) are extracellular matrix structures that regulate n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3939d4e5d681996f6a9112c3b4675f93
https://doi.org/10.2337/db22-152-or
https://doi.org/10.2337/db22-152-or
Autor:
LETICIA E. SEWAYBRICKER, KELSEY OLERICH, SARAH L. KEE, SUSAN J. MELHORN, SUCHITRA CHANDRASEKARAN, ELLEN SCHUR
Publikováno v:
Diabetes. 71
In utero exposure to gestational diabetes (GDM) or hypertension (HYP) is associated with child obesity. These maternal conditions alter the in utero milieu and may predispose offspring to obesity via an effect on the brain. Cellular inflammation (gli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64644bc485f24c251cdded67b1e0c17f
https://doi.org/10.2337/db22-343-or
https://doi.org/10.2337/db22-343-or
Autor:
Mary K. Askren, Trevor K McAllister-Day, Natalie eKoh, Zoe eMestre, Jennifer N Dines, Benjamin A Korman, Susan J Melhorn, Daniel J Peterson, Matthew ePeverill, Xiaoyan eQin, Swati D Rane, Melissa A Reilly, Maya A Reiter, Kelly A Sambrook, Karl A Woelfer, Thomas J Grabowski, Tara M Madhyastha
Publikováno v:
Frontiers in Neuroinformatics, Vol 10 (2016)
The contribution of this paper is to describe how we can program neuroimaging workflow using Make, a software development tool designed for describing how to build executables from source files. We show that we can achieve many of the features of mor
Externí odkaz:
https://doaj.org/article/8743eba0560c4e92ad3ba16b03d3b033
Autor:
Kelley Scholz, Brian E. Saelens, Mary Rosalynn B. De Leon, Christian L. Roth, Susan J. Melhorn, Clinton Elfers, Maya Rowland, Ellen A. Schur
Publikováno v:
International journal of obesity (2005)
Background and Objectives: Family-based behavioral treatment (FBT) is the recommended treatment for children with common obesity. However, there is a large variability in short- and long-term treatment response and mechanisms for unsuccessful treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b87e31a2f6906cbfedea625baf8bda05
http://europepmc.org/articles/PMC7530004
http://europepmc.org/articles/PMC7530004
