Zobrazeno 1 - 10
of 23
pro vyhledávání: '"J Matthew Franklin"'
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
The transcriptional regulator YAP shuttles rapidly between the cytoplasm and nucleus, but whether and how dynamics such as amplitude and frequency affect target gene transcription is unclear. Here, using live imaging of endogenous YAP and target-gene
Externí odkaz:
https://doaj.org/article/b74055e5260d4791ba53349afa233f25
Autor:
Linfeng Yang, Rajarshi P Ghosh, J Matthew Franklin, Simon Chen, Chenyu You, Raja R Narayan, Marc L Melcher, Jan T Liphardt
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 9, p e1008193 (2020)
Segmenting cell nuclei within microscopy images is a ubiquitous task in biological research and clinical applications. Unfortunately, segmenting low-contrast overlapping objects that may be tightly packed is a major bottleneck in standard deep learni
Externí odkaz:
https://doaj.org/article/b1465e3dfd0347d695e217e01e9ead8e
Autor:
Fu‐Long Li, Zhengming Wu, Yong‐Qi Gao, Forrest Z Bowling, J Matthew Franklin, Chongze Hu, Raymond T Suhandynata, Michael A Frohman, Michael V Airola, Huilin Zhou, Kun‐Liang Guan
Publikováno v:
The EMBO journal. 41(17)
The Arf GTPase family is involved in a wide range of cellular regulation including membrane trafficking and organelle-structure assembly. Here, we have generated a proximity interaction network for the Arf family using the miniTurboID approach combin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ff547e2882f1b7c7d74775ebe9e7b50
https://pubmed.ncbi.nlm.nih.gov/35844135
https://pubmed.ncbi.nlm.nih.gov/35844135
Autor:
J Matthew, Franklin, Kun-Liang, Guan
Publikováno v:
Nature cell biology. 22(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b598567e3c560aa86193786be78b4199
https://pubmed.ncbi.nlm.nih.gov/32203417
https://pubmed.ncbi.nlm.nih.gov/32203417
Autor:
Jan Liphardt, Vivek B. Shenoy, Ovijit Chaudhuri, J. Matthew Franklin, Lucas R. Smith, Rebecca G. Wells, Ehsan Ban, Hailong Wang, Sungmin Nam
Publikováno v:
Biophysical journal, vol 114, iss 2
Contractile cells can reorganize fibrous extracellular matrices and form dense tracts of fibers between neighboring cells. These tracts guide the development of tubular tissue structures and provide paths for the invasion of cancer cells. Here, we st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68af1dc7568a80672ff81bf35f6ca403
https://doi.org/10.1016/j.bpj.2017.11.3739
https://doi.org/10.1016/j.bpj.2017.11.3739
Autor:
Kun-Liang Guan, J. Matthew Franklin
Publikováno v:
Nature Cell Biology. 22:357-358
YAP and TAZ, paralogous mammalian genes, act as the key transcriptional effectors of the Hippo pathway. Two recent reports show that both YAP and TAZ form liquid–liquid phase-separated bodies that promote gene transcription by engaging in super-enh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8716738838614f03cf36049d2525ee57
https://doi.org/10.1038/s41556-020-0498-8
https://doi.org/10.1038/s41556-020-0498-8
Segmenting cell nuclei within microscopy images is a ubiquitous task in biological research and clinical applications. Unfortunately, segmenting low-contrast overlapping objects that may be tightly packed is a major bottleneck in standard deep learni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7ddc36455a0ac84d247bb863d9c10e0
https://doi.org/10.1101/749754
https://doi.org/10.1101/749754
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications
Nature Communications
Yes-associated protein 1 (YAP) is a transcriptional regulator with critical roles in mechanotransduction, organ size control, and regeneration. Here, using advanced tools for real-time visualization of native YAP and target gene transcription dynamic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2edfdd040999efe4cd4e95f5b455e4fa
https://pubmed.ncbi.nlm.nih.gov/32917893
https://pubmed.ncbi.nlm.nih.gov/32917893
Autor:
Rajarshi P. Ghosh, Will E Draper, J. Matthew Franklin, Jan Liphardt, Quanming Shi, Bruno Beltran, Andrew J. Spakowitz
Publikováno v:
Nature chemical biology. 15(4)
We describe three optical tags, ArrayG, ArrayD and ArrayG/N, for intracellular tracking of single molecules over milliseconds to hours. ArrayG is a fluorogenic tag composed of a green fluorescent protein–nanobody array and monomeric wild-type green
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d934c0b8138da0a38e35fc547819fe
https://pubmed.ncbi.nlm.nih.gov/30858596
https://pubmed.ncbi.nlm.nih.gov/30858596
Cellular processes take place over many timescales, prompting the development of precision measurement technologies that cover milliseconds to hours. Here we describe ArrayG, a bipartite fluorogenic system composed of a GFP-nanobody array and monomer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cf6b37cdb07ad2b902667fde1f73c3b