Zobrazeno 1 - 10
of 118
pro vyhledávání: '"J Martinko"'
Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers
Autor:
Shion A. Lim, Jie Zhou, Alexander J. Martinko, Yung-Hua Wang, Ekaterina V. Filippova, Veronica Steri, Donghui Wang, Soumya G. Remesh, Jia Liu, Byron Hann, Anthony A. Kossiakoff, Michael J. Evans, Kevin K. Leung, James A. Wells
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 4 (2022)
Extracellular proteolysis is frequently dysregulated in disease and can generate proteoforms with unique neoepitopes not found in healthy tissue. Here, we demonstrate that Abs that selectively recognize a proteolytic neoepitope on CUB domain containi
Externí odkaz:
https://doaj.org/article/185e24f5d7a047799beb370607485344
Autor:
Alexander J. Martinko, Hai L. Tran, Erin F. Simonds, Allison L. Cooke, Zhong Huang, Sruthi Raguveer, Judit Pina Agullet, Suchitra Prasad, Catherine Going, Lisa Marshall, Timothy Park, Sunandan Banerjee, Ramsay Macdonald, Mike Jian, Kenneth Ng, Akhila Palakodaty, Manpreet Kaur, Alberto Ponce, Mohammad Tabrizi, Zachary B. Hill
We present the Indinavir Ligand Induced Transient Engagement switch (IDV LITE Switch), a fully synthetic Chemically Induced Dimerization (CID) system wherein two humanized antibody fragments are heterodimerized by the antiviral drug indinavir. The ID
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aec52542b6a41c94cab1387fad21768d
https://doi.org/10.1101/2023.04.11.536272
https://doi.org/10.1101/2023.04.11.536272
Autor:
Michael J. Evans, James A. Wells, Kimberly S. Kirkwood, Eric A. Collisson, Kevin K. Leung, Sean Carlin, Youngho Seo, Lydia H. Zhang, Shion A. Lim, Jie Zhuo, Alexander J. Martinko, Zhuo Chen, Yangjie Huang, Ning Zhao, Junnian Wei, Jeremy M. Sharib, Yung-Hua Wang, Anna Moroz
Purpose:The recent emergence of radioligand therapies for cancer treatment has increased enthusiasm for developing new theranostic strategies coupling both imaging and cytotoxicity in the same entity. In this study, we evaluated whether CUB domain co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a058b3064dd4e9ecfa3f980c0898668c
https://doi.org/10.1158/1078-0432.c.6528857
https://doi.org/10.1158/1078-0432.c.6528857
Autor:
Michael J. Evans, James A. Wells, Kimberly S. Kirkwood, Eric A. Collisson, Kevin K. Leung, Sean Carlin, Youngho Seo, Lydia H. Zhang, Shion A. Lim, Jie Zhuo, Alexander J. Martinko, Zhuo Chen, Yangjie Huang, Ning Zhao, Junnian Wei, Jeremy M. Sharib, Yung-Hua Wang, Anna Moroz
Supplemental methods, figures, and tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd76320a99a43971b362aaab78f2138e
https://doi.org/10.1158/1078-0432.22474655
https://doi.org/10.1158/1078-0432.22474655
Autor:
Alexander J Martinko, Charles Truillet, Olivier Julien, Juan E Diaz, Max A Horlbeck, Gordon Whiteley, Josip Blonder, Jonathan S Weissman, Sourav Bandyopadhyay, Michael J Evans, James A Wells
Publikováno v:
eLife, Vol 7 (2018)
While there have been tremendous efforts to target oncogenic RAS signaling from inside the cell, little effort has focused on the cell-surface. Here, we used quantitative surface proteomics to reveal a signature of proteins that are upregulated on ce
Externí odkaz:
https://doaj.org/article/effb67b1d9ed4b8785dee707219f397c
Autor:
Alexander J. Martinko, Erin F. Simonds, Suchitra Prasad, Alberto Ponce, Colton J. Bracken, Junnian Wei, Yung-Hua Wang, Tiffany-Lynn Chow, Zhong Huang, Michael J. Evans, James A. Wells, Zachary B. Hill
Publikováno v:
Proceedings of the National Academy of Sciences. 119
The antigen specificity and long serum half-life of monoclonal antibodies have made them a critical part of modern therapeutics. These properties have been coopted in a number of synthetic formats, such as antibody-drug conjugates, bispecific antibod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a6ed10a79114365899c2f9172d7d10
https://doi.org/10.1073/pnas.2117402119
https://doi.org/10.1073/pnas.2117402119
Autor:
Mark J. Martinko, Jeremy D. Mackey
Publikováno v:
Journal of Organizational Behavior. 40:523-527
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::706559a841c827149ea47d8290406207
https://doi.org/10.1002/job.2397
https://doi.org/10.1002/job.2397
Autor:
Kevin Leung, Michael J. Evans, Soumya G. Remesh, J. Liu, Alexander J. Martinko, James A. Wells, Byron Hann, Doris D. Wang, Shion A. Lim, Steri, Anthony A. Kossiakoff, Yong Qiang Wang, Jie Zhou, Ekaterina V Filippova
A central challenge for any therapeutic is targeting diseased over normal cells. Proteolysis is frequently upregulated in disease and can generate proteoforms with unique neo-epitopes. We hypothesize that targeting proteolytic neo-epitopes can enable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a25087b46dc59256c3105471e797405
https://doi.org/10.1101/2021.06.14.448427
https://doi.org/10.1101/2021.06.14.448427
Autor:
Leonel Torres, James Byrnes, Anum A. Glasgow, Michael J. Peluso, Taia T. Wang, Timothy J. Henrich, Kevin Leung, Alexander J. Martinko, Nikita S. Iyer, Xin X. Zhou, James A. Wells, Katarina Pance, Keirstinne Turcios, Cristina M. Tato, Bryan Greenhouse, Jeff E. Glasgow, Susanna K. Elledge, Shion A. Lim, Irene Lui
Publikováno v:
Nat Biotechnol
medRxiv
article-version (status) pre
article-version (number) 1
Nature biotechnology, vol 39, iss 8
medRxiv
article-version (status) pre
article-version (number) 1
Nature biotechnology, vol 39, iss 8
Current serology tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies mainly take the form of enzyme-linked immunosorbent assays, chemiluminescent microparticle immunoassays or lateral flow assays, which are either labori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f1c6c05844561f1bb9ccc000d7b7cef
https://europepmc.org/articles/PMC8355051/
https://europepmc.org/articles/PMC8355051/
Publikováno v:
Journal of leadershiporganizational studies. 29(2)
In the current series of studies, we draw upon implicit leadership theories, social learning theory, and research on decision making to investigate whether affect toward President Trump explains U.S. residents’ evaluations of his leadership during
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d1c6681bf31d1025bb19ae6295e2b4
https://pubmed.ncbi.nlm.nih.gov/35516095
https://pubmed.ncbi.nlm.nih.gov/35516095