Zobrazeno 1 - 10
of 402
pro vyhledávání: '"J Marsac"'
Publikováno v:
Pharmaceutical Research. 39:2033-2047
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76405aadfe798587a89bde65c8d96425
https://doi.org/10.1007/s11095-022-03248-4
https://doi.org/10.1007/s11095-022-03248-4
Autor:
Yongchao Su, Mingyue Li, Wei Xu, Xingyu Lu, Patrick J. Marsac, Yaqiang Wang, Matthew J Nethercott, Jing Ling, Eric J. Munson, Freddy A Arce, Xiaohuo Shi, Nico Setiawan, Heather R. Campbell
Publikováno v:
Molecular Pharmaceutics. 18:4310-4321
The introduction of solubilizing additives has historically been an attractive approach to address the ever-growing proportion of poorly water-soluble drug (PWSD) compounds within the modern drug discovery pipeline. Lipid-formulations, and more speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fda0e6a2433702628b2fac9f0f8e255
https://doi.org/10.1021/acs.molpharmaceut.1c00477
https://doi.org/10.1021/acs.molpharmaceut.1c00477
Publikováno v:
Journal of Pharmaceutical Innovation. 17:194-206
D-tagatose is an alternative sweetener with superior properties for reducing overall sugar absorption, which is especially important in the diabetic population. Large-scale production of D-tagatose remains costly, thereby limiting its commercializati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c82a357bff1ad70c0cc9d34cef3935c2
https://doi.org/10.1007/s12247-020-09507-4
https://doi.org/10.1007/s12247-020-09507-4
Autor:
Patrick J. Marsac, Freddy A Arce, Paul M. Bummer, Matthew J Nethercott, Nico Setiawan, Heather R. Campbell, Yongchao Su, Xingyu Lu
Publikováno v:
Molecular Pharmaceutics. 17:4125-4140
Enabling formulations are an attractive approach to increase the dissolution rate, solubility, and oral bioavailability of poorly soluble compounds. With the growing prevalence of poorly soluble drug compounds in the pharmaceutical pipeline, supersat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e583adcd9c4fb6c2061477d4530163
https://doi.org/10.1021/acs.molpharmaceut.0c00599
https://doi.org/10.1021/acs.molpharmaceut.0c00599
Autor:
Matthew K. Defrese, Lucas R. Timmerman, Patrick J. Marsac, Younsoo Bae, Yuhan Long, Matthew A. Farmer
Publikováno v:
Molecular pharmaceutics. 17(12)
It is well established that polymers adopt a range of conformations and solution-state organization in response to varying solution environments, although very little work has been done to understand how these effects might impact the physical stabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b4c631c471f31cf174a72cb9687929
https://pubmed.ncbi.nlm.nih.gov/32965120
https://pubmed.ncbi.nlm.nih.gov/32965120
Publikováno v:
International Journal of Heat and Mass Transfer. 122:863-876
Although spray drying is widely used to produce active pharmaceutical ingredients, its operation and improvement is often difficult to assess because of complex interactions between the chemical and physical properties of the solutions, and the ensui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94cf6aa810c52892f090608ed1d339fb
https://doi.org/10.1016/j.ijheatmasstransfer.2018.02.043
https://doi.org/10.1016/j.ijheatmasstransfer.2018.02.043
Publikováno v:
Powder Technology. 333:439-448
The scaling-up of spray drying processes is an important and challenging step in commercializing specialty products with an ensured quality because it mandates a comprehensive understanding of several steps in the process such as atomization, efficie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11a0085d6acc43214ac6200dee97f046
https://doi.org/10.1016/j.powtec.2018.04.064
https://doi.org/10.1016/j.powtec.2018.04.064
Publikováno v:
Chemical Engineering Science. 180:42-51
Spray drying as a commonly used process to produce amorphous solid dispersions of poorly water soluble active pharmaceutical ingredients (API) involves dissolution of the API and often a polymer, surfactant, and/or other functional excipient(s) into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a25effdd2a4994a3601b81a29afd63a
https://doi.org/10.1016/j.ces.2018.01.033
https://doi.org/10.1016/j.ces.2018.01.033
Autor:
Haichen Nie, Patrick J. Marsac, Yongchao Su, Hang Lau, Nico Setiawan, Lynne S. Taylor, Matthew K. Defrese, Jonas Alin, James DiNunzio, Hanmi Xi, Nathan Hesse, Lisa Lupton
Publikováno v:
Polymer. 135:50-60
The utility of amorphization of drug molecules, such as enhanced solubility, dissolution rate and oral bioavailability, has been well exemplified in the literature. Yet, the application of this technique is often hindered by the crystallization liabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2579c68485d1841a71e5ed4bbec19b5a
https://doi.org/10.1016/j.polymer.2017.11.056
https://doi.org/10.1016/j.polymer.2017.11.056
Autor:
Lynne S. Taylor, Elise Miller, Patrick J. Marsac, Niraj S. Trasi, Narayan Variankaval, Clara Correa-Soto, Garth J. Simpson, Paul D. Schmitt, Yongchao Su, Zhen Liu
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 146:86-95
Various techniques have been used to detect crystallization in amorphous solid dispersions (ASD). However, most of these techniques do not enable the detection of very low levels of crystallinity (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6019cf141bcbbff06e00edf6bb28af33
https://doi.org/10.1016/j.jpba.2017.07.066
https://doi.org/10.1016/j.jpba.2017.07.066