Zobrazeno 1 - 10
of 84
pro vyhledávání: '"J Mark Skehel"'
Autor:
Sara Alvira, Daniel W Watkins, Luca A Troman, William J Allen, James S Lorriman, Gianluca Degliesposti, Eli J Cohen, Morgan Beeby, Bertram Daum, Vicki AM Gold, J Mark Skehel, Ian Collinson
Publikováno v:
eLife, Vol 9 (2020)
The outer-membrane of Gram-negative bacteria is critical for surface adhesion, pathogenicity, antibiotic resistance and survival. The major constituent – hydrophobic β-barrel Outer-Membrane Proteins (OMPs) – are first secreted across the inner-m
Externí odkaz:
https://doaj.org/article/f24b1cd117cb40268b4bfbcedb0b00c8
Autor:
Anna Olivieri, Christine R Collins, Fiona Hackett, Chrislaine Withers-Martinez, Joshua Marshall, Helen R Flynn, J Mark Skehel, Michael J Blackman
Publikováno v:
PLoS Pathogens, Vol 7, Iss 12, p e1002448 (2011)
The malarial life cycle involves repeated rounds of intraerythrocytic replication interspersed by host cell rupture which releases merozoites that rapidly invade fresh erythrocytes. Apical membrane antigen-1 (AMA1) is a merozoite protein that plays a
Externí odkaz:
https://doaj.org/article/315023ec66314c8f90517f6adb5ede7a
Autor:
Andreas Hadjicharalambous, Philip Zegerman, Geylani Can, Alex J. Whale, Jonathan M. Houseley, J. Mark Skehel
Publikováno v:
Wellcome Open Research, Vol 8 (2023)
Background: In eukaryotes, replication stress activates a checkpoint response, which facilitates genome duplication by stabilising the replisome. How the checkpoint kinases regulate the replisome remains poorly understood. The aim of this study is to
Externí odkaz:
https://doaj.org/article/c1551f0907c54050b2cc46ae7dc9d569
Autor:
Tim Nierhaus, Stephen H. McLaughlin, Frank Bürmann, Danguole Kureisaite-Ciziene, Sarah L. Maslen, J. Mark Skehel, Conny W. H. Yu, Stefan M. V. Freund, Louise F. H. Funke, Jason W. Chin, Jan Löwe
Publikováno v:
Nature Microbiology. 7:1686-1701
During bacterial cell division, filaments of tubulin-like FtsZ form the Z-ring, which is the cytoplasmic scaffold for divisome assembly. In Escherichia coli, the actin homologue FtsA anchors the Z-ring to the membrane and recruits divisome components
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c86d9870695cc5a6de38f025a15dd11
https://doi.org/10.1038/s41564-022-01206-9
https://doi.org/10.1038/s41564-022-01206-9
Autor:
Christopher J. Staples, Giancarlo Barone, Katie N. Myers, Anil Ganesh, Ian Gibbs-Seymour, Abhijit A. Patil, Ryan D. Beveridge, Caroline Daye, Richard Beniston, Sarah Maslen, Ivan Ahel, J. Mark Skehel, Spencer J. Collis
Publikováno v:
Cell Reports, Vol 16, Iss 10, Pp 2565-2575 (2016)
Through an RNAi-based screen for previously uncharacterized regulators of genome stability, we have identified the human protein C5orf45 as an important factor in preventing the accumulation of DNA damage in human cells. Here, we functionally charact
Externí odkaz:
https://doaj.org/article/364b3ced153a49d6af34bb714c11f64b
Autor:
Zuzana Hořejší, Lasse Stach, Thomas G. Flower, Dhira Joshi, Helen Flynn, J. Mark Skehel, Nicola J. O’Reilly, Roksana W. Ogrodowicz, Stephen J. Smerdon, Simon J. Boulton
Publikováno v:
Cell Reports, Vol 7, Iss 1, Pp 19-26 (2014)
The R2TP cochaperone complex plays a critical role in the assembly of multisubunit machines, including small nucleolar ribonucleoproteins (snoRNPs), RNA polymerase II, and the mTORC1 and SMG1 kinase complexes, but the molecular basis of substrate rec
Externí odkaz:
https://doaj.org/article/0bd16e8c92024324bc3a105974c3400b
Autor:
Venki Ramakrishnan, Yuliya Gordiyenko, Jailson Brito Querido, Masaaki Sokabe, Sebastian Kraatz, J. Mark Skehel, Christopher S. Fraser
Publikováno v:
Science
Science (New York, N.Y.), vol 369, iss 6508
Science (New York, N.Y.), vol 369, iss 6508
Finding the start Eukaryotic translation involves many players in a dynamic and well-orchestrated process. A 43 S preinitiation complex (PIC) comprises the 40 S ribosomal subunit; initiation factors, including the eIF3 complex, which is known to play
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4b331fad5070599c757af01039be1d6
https://doi.org/10.1126/science.aba4904
https://doi.org/10.1126/science.aba4904
Autor:
Marina Serna, Ana González-Corpas, Sofía Cabezudo, Andrés López-Perrote, Gianluca Degliesposti, Eduardo Zarzuela, J Mark Skehel, Javier Muñoz, Oscar Llorca
Publikováno v:
Repisalud
Instituto de Salud Carlos III (ISCIII)
Nucleic Acids Research
Instituto de Salud Carlos III (ISCIII)
Nucleic Acids Research
Biogenesis of the U5 small nuclear ribonucleoprotein (snRNP) is an essential and highly regulated process. In particular, PRPF8, one of U5 snRNP main components, requires HSP90 working in concert with R2TP, a cochaperone complex containing RUVBL1 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::042da87a0d69814c00aecbb6141dd6c6
https://hdl.handle.net/20.500.12105/13716
https://hdl.handle.net/20.500.12105/13716
Autor:
Byron Andrews, Alan E. Murphy, Michele Stofella, Sarah Maslen, Leonardo Almeida-Souza, J. Mark Skehel, Nathan G. Skene, Frank Sobott, René A.W. Frank
Neurodegenerative diseases are characterized by the abnormal accumulation of aggregated proteins in the brain. Using in vivo pulse isotope labeling, we screened the proteome for changes in protein turnover and abundance in multiple mouse models of ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ea7dc04ce65e99e1f8cb116d222e1e
http://hdl.handle.net/10138/356000
http://hdl.handle.net/10138/356000
Autor:
J. Mark Skehel, Ian L. Dale, Mark S. B. McAlister, Christopher D. Stubbs, Francesca Malvezzi, Jon P. DeGnore, Thomas A. Jowitt, Xieyang Guo, Andrew J. Bannister, Gianluca Degliesposti
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Communications Biology
Communications Biology
Funder: AstraZeneca; doi: https://doi.org/10.13039/100004325
Funder: AstraZeneca postdoc fund
Bromodomain-containing protein 4 (BRD4) is an epigenetic reader and oncology drug target that regulates gene transcription through binding to acet
Funder: AstraZeneca postdoc fund
Bromodomain-containing protein 4 (BRD4) is an epigenetic reader and oncology drug target that regulates gene transcription through binding to acet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed0831170bd5bba64f873b650d080de1