Zobrazeno 1 - 10
of 130
pro vyhledávání: '"J Mark, Wilkinson"'
Autor:
Joanna McLaughlin, Ruth Kipping, Amanda Owen-Smith, Hugh McLeod, Samuel Hawley, J. Mark Wilkinson, Andrew Judge
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-13 (2023)
Abstract Background Despite their widespread use, the impact of commissioners’ policies for body mass index (BMI) for access to elective surgery is not clear. Policy use varies by locality, and there are concerns that these policies may worsen heal
Externí odkaz:
https://doaj.org/article/ea775f4c57664fc1b69668200806a4f3
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-13 (2023)
Abstract Background Investigation of cartilage and chondrocytes has revealed that the osteoarthritis risk marked by the independent DNA variants rs11583641 and rs1046934 mediate their effects by decreasing the methylation status of CpG dinucleotides
Externí odkaz:
https://doaj.org/article/d3db7e5027b6495781391d28190ee6fc
Autor:
Tesfaye H Leta, Anne Marie Fenstad, Stein Håkon L Lygre, Stein Atle Lie, Martin Lindberg-Larsen, Alma B Pedersen, Annette W-Dahl, Ola Rolfson, Erik Bülow, James A Ashforth, Liza N van Steenbergen, Rob G H H Nelissen, Dylan Harries, Richard De Steiger, Olav Lutro, Emmi Hakulinen, Keijo Mäkelä, Jinny Willis, Michael Wyatt, Chris Frampton, Alexander Grimberg, Arnd Steinbrück, Yinan Wu, Cristiana Armaroli, Marco Molinari, Roberto Picus, Kyle Mullen, Richard Illgen, Ioan C Stoica, Andreea E Vorovenci, Dan Dragomirescu, Håvard Dale, Christian Brand, Bernhard Christen, Joanne Shapiro, J Mark Wilkinson, Richard Armstrong, Kate Wooster, Geir Hallan, Jan-Erik Gjertsen, Richard N Chang, Heather A Prentice, Elizabeth W Paxton, Ove Furnes
Publikováno v:
Acta Orthopaedica, Vol 94 (2023)
Background and purpose: Antibiotic-loaded bone cement (ALBC) and systemic antibiotic prophylaxis (SAP) have been used to reduce periprosthetic joint infection (PJI) rates. We investigated the use of ALBC and SAP in primary total knee arthroplasty (TK
Externí odkaz:
https://doaj.org/article/b21cbc13a46b4c84a55c71ec58b5cb3b
Autor:
Christopher Boulton, Carol Harrison, Timothy Wilton, Richard Armstrong, Elaine Young, Derek Pegg, J. Mark Wilkinson
Publikováno v:
Bone & Joint Open, Vol 3, Iss 9, Pp 716-725 (2022)
Data of high quality are critical for the meaningful interpretation of registry information. The National Joint Registry (NJR) was established in 2002 as the result of an unexpectedly high failure rate of a cemented total hip arthroplasty. The NJR be
Externí odkaz:
https://doaj.org/article/225344d6512f4fd39f5104f0fa031dc0
Autor:
Alan J Silman, Christophe Combescure, Rory J Ferguson, Stephen E Graves, Elizabeth W Paxton, Chris Frampton, Ove Furnes, Anne Marie Fenstad, Gary Hooper, Anne Garland, Anneke Spekenbrink-Spooren, J Mark Wilkinson, Keijo Mäkelä, Anne Lübbeke, Ola Rolfson
Publikováno v:
Acta Orthopaedica, Vol 92, Iss 3, Pp 304-310 (2021)
Background and purpose — A challenge comparing outcomes from total hip arthroplasty between countries is variation in preoperative characteristics, particularly comorbidity. Therefore, we investigated between-country variation in comorbidity in pat
Externí odkaz:
https://doaj.org/article/7d54d5af1b564d11be5c6f704bf24f71
Autor:
Julia Steinberg, Lorraine Southam, Theodoros I. Roumeliotis, Matthew J. Clark, Raveen L. Jayasuriya, Diane Swift, Karan M. Shah, Natalie C. Butterfield, Roger A. Brooks, Andrew W. McCaskie, J. H. Duncan Bassett, Graham R. Williams, Jyoti S. Choudhary, J. Mark Wilkinson, Eleftheria Zeggini
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Understanding the molecular effects of disease variants in relevant tissues is essential to understanding and treating disease. Here, the authors discover expression and protein quantitative trait loci in cartilage and synovium from 115 osteoarthriti
Externí odkaz:
https://doaj.org/article/dcec7e1450ec48c58e6b36aa6fd093ff
Autor:
Natalie C. Butterfield, Katherine F. Curry, Julia Steinberg, Hannah Dewhurst, Davide Komla-Ebri, Naila S. Mannan, Anne-Tounsia Adoum, Victoria D. Leitch, John G. Logan, Julian A. Waung, Elena Ghirardello, Lorraine Southam, Scott E. Youlten, J. Mark Wilkinson, Elizabeth A. McAninch, Valerie E. Vancollie, Fiona Kussy, Jacqueline K. White, Christopher J. Lelliott, David J. Adams, Richard Jacques, Antonio C. Bianco, Alan Boyde, Eleftheria Zeggini, Peter I. Croucher, Graham R. Williams, J. H. Duncan Bassett
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Osteoarthritis is a chronic, heritable disease with no available treatment. Here, the authors show that a validated, rapid-throughput joint phenotyping pipeline detects osteoarthritis in the mouse knee following surgical provocation, in aging and aft
Externí odkaz:
https://doaj.org/article/edbe1f565dfb4cb59b5b96ecd707f7bc
Autor:
Joanna McLaughlin, Ruth Kipping, Amanda Owen-Smith, Hugh McLeod, Samuel Hawley, J Mark Wilkinson, Andrew Judge
Publikováno v:
PLoS ONE, Vol 17, Iss 6, p e0270274 (2022)
ObjectiveTo assess the impact of local commissioners' policies for body mass index on access to knee replacement surgery in England.MethodsA Natural Experimental Study using interrupted time series and difference-in-differences analysis. We used Nati
Externí odkaz:
https://doaj.org/article/38b4d44275bb474a974bc7ac8b7e0508
Autor:
Diane Lefley, Faith Howard, Fawaz Arshad, Steven Bradbury, Hannah Brown, Claudia Tulotta, Rachel Eyre, Denis Alférez, J. Mark Wilkinson, Ingunn Holen, Robert B. Clarke, Penelope Ottewell
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-21 (2019)
Abstract Background Late-stage breast cancer preferentially metastasises to bone; despite advances in targeted therapies, this condition remains incurable. The lack of clinically relevant models for studying breast cancer metastasis to a human bone m
Externí odkaz:
https://doaj.org/article/9c41d0f7f3c5497c955ee94df5a3474b
Autor:
Albert Prats-Uribe, Spyros Kolovos, Klara Berencsi, Andrew Carr, Andrew Judge, Alan Silman, Nigel Arden, Irene Petersen, Ian J Douglas, J Mark Wilkinson, David Murray, Jose M Valderas, David J Beard, Sarah E Lamb, M Sanni Ali, Rafael Pinedo-Villanueva, Victoria Y Strauss, Daniel Prieto-Alhambra
Publikováno v:
Health Technology Assessment, Vol 25, Iss 66 (2021)
Background: Although routine NHS data potentially include all patients, confounding limits their use for causal inference. Methods to minimise confounding in observational studies of implantable devices are required to enable the evaluation of patien
Externí odkaz:
https://doaj.org/article/08119d74bbdd4f1f89c190f51944fe4c