Zobrazeno 1 - 10
of 602
pro vyhledávání: '"J Marc, Simard"'
Autor:
Chenyu Zhang, Volodymyr Gerzanich, Ruth Cruz-Cosme, Jiantao Zhang, Orest Tsymbalyuk, Cigdem Tosun, Bhargava Teja Sallapalli, Dongxiao Liu, Kaspar Keledjian, John C. Papadimitriou, Cinthia B. Drachenberg, Mohamed Nasr, Yanjin Zhang, Qiyi Tang, J. Marc Simard, Richard Y. Zhao
Publikováno v:
mBio, Vol 15, Iss 11 (2024)
ABSTRACT The primary challenge posed by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is COVID-19-related mortality, often exacerbated by additional medical complications, such as COVID-19-associated kidney injuries (CAKIs).
Externí odkaz:
https://doaj.org/article/900650a8a1e74d1dae1d954fd7e47921
Autor:
Tapas K. Makar, Poornachander R. Guda, Sugata Ray, Sanketh Andhavarapu, Kaspar Keledjian, Volodymyr Gerzanich, J. Marc Simard, Vamshi K. C. Nimmagadda, Christopher T. Bever
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Endoplasmic reticulum (ER) stress and mitochondrial dysfunction are found in lesions of multiple sclerosis (MS) and animal models of MS such as experimental autoimmune encephalomyelitis (EAE), and may contribute to the neuronal loss that und
Externí odkaz:
https://doaj.org/article/ec5ae10a586a4fbf80b3041178566058
Autor:
Jessica Cummings, Yijen L. Wu, C. Edward Dixon, Jeremy Henchir, J. Marc Simard, Ashok Panigrahy, Patrick M. Kochanek, Ruchira M. Jha, Rajesh K. Aneja
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-11 (2023)
Abstract Sepsis-associated brain injury (SABI) is characterized by an acute deterioration of mental status resulting in cognitive impairment and acquisition of new and persistent functional limitations in sepsis survivors. Previously, we reported tha
Externí odkaz:
https://doaj.org/article/09fef268cec240d990a9cc47f2ca7af1
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-16 (2022)
Abstract Background Pathophysiological consequences of traumatic brain injury (TBI) mediated secondary injury remain incompletely understood. In particular, the impact of TBI on the differentiation and maintenance of dendritic cells (DCs), which are
Externí odkaz:
https://doaj.org/article/452503069c4a4d45aaef5f0613a16b04
Autor:
Shenqi Zhang, Bin Peng, Zeming Chen, Jiang Yu, Gang Deng, Youmei Bao, Chao Ma, Fengyi Du, Wendy C. Sheu, W. Taylor Kimberly, J. Marc Simard, Daniel Coman, Qianxue Chen, Fahmeed Hyder, Jiangbing Zhou, Kevin N. Sheth
Publikováno v:
Bioactive Materials, Vol 16, Iss , Pp 57-65 (2022)
Stroke is the leading cause of death and disability. Currently, there is no effective pharmacological treatment for this disease, which can be partially attributed to the inability to efficiently deliver therapeutics to the brain. Here we report the
Externí odkaz:
https://doaj.org/article/b2d82bb2d70f483b9966733478e29137
Autor:
J. Marc Simard, Bradley Wilhelmy, Natalya Tsymbalyuk, Bosung Shim, Jesse A. Stokum, Madison Evans, Anandita Gaur, Cigdem Tosun, Kaspar Keledjian, Prajwal Ciryam, Riccardo Serra, Volodymyr Gerzanich
Publikováno v:
Brain Sciences, Vol 14, Iss 3, p 229 (2024)
In human stroke, brain swelling is an important predictor of neurological outcome and mortality, yet treatments to reduce or prevent brain swelling are extremely limited, due in part to an inadequate understanding of mechanisms. In preclinical studie
Externí odkaz:
https://doaj.org/article/c88f3a70ab504422be2af4e18e61d667
Autor:
Jiantao Zhang, Kellie Hom, Chenyu Zhang, Mohamed Nasr, Volodymyr Gerzanich, Yanjin Zhang, Qiyi Tang, Fengtian Xue, J. Marc Simard, Richard Y. Zhao
Publikováno v:
Pathogens, Vol 13, Iss 1, p 75 (2024)
The COVID-19 pandemic caused by SARS-CoV-2 has posed unparalleled challenges due to its rapid transmission, ability to mutate, high mortality and morbidity, and enduring health complications. Vaccines have exhibited effectiveness, but their efficacy
Externí odkaz:
https://doaj.org/article/2064859716c941f99d4567ae8e898eb7
Autor:
Riccardo Serra, J. Marc Simard
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
IntroductionThe movement of fluids and solutes across the ependymal barrier, and their changes in physiologic and disease states are poorly understood. This gap in knowledge contributes strongly to treatment failures and complications in various neur
Externí odkaz:
https://doaj.org/article/28b065af4646423595c0ab7cecaed60f
Autor:
Bosung Shim, Jesse A. Stokum, Mitchell Moyer, Natalya Tsymbalyuk, Orest Tsymbalyuk, Kaspar Keledjian, Svetlana Ivanova, Cigdem Tosun, Volodymyr Gerzanich, J. Marc Simard
Publikováno v:
Cells, Vol 12, Iss 18, p 2221 (2023)
Brain swelling is a major cause of death and disability in ischemic stroke. Drugs of the gliflozin class, which target the Na+-coupled D-glucose cotransporter, SGLT2, are approved for type 2 diabetes mellitus (T2DM) and may be beneficial in other con
Externí odkaz:
https://doaj.org/article/a4ba6993b6224859895e1d4f7697e548
Autor:
Natallia Makarava, Olga Mychko, Kara Molesworth, Jennifer Chen-Yu Chang, Rebecca J. Henry, Natalya Tsymbalyuk, Volodymyr Gerzanich, J. Marc Simard, David J. Loane, Ilia V. Baskakov
Publikováno v:
Cells, Vol 12, Iss 17, p 2172 (2023)
The transformation of astrocytes into reactive states constitutes a biological response of the central nervous system under a variety of pathological insults. Astrocytes display diverse homeostatic identities that are developmentally predetermined an
Externí odkaz:
https://doaj.org/article/5e70c87ed62d438aa49588aacb632718