Zobrazeno 1 - 10
of 1 883
pro vyhledávání: '"J Mahoney A"'
Autor:
Jahanara Rajwani, Daniil Vishnevskiy, Madison Turk, Victor Naumenko, Chris Gafuik, Dae-Sun Kim, Laura K. Mah, Shannon Snelling, Gerone A. Gonzales, Jingna Xue, Ayan Chanda, Kyle G. Potts, Hayley M. Todesco, Keith C. K. Lau, Karys M. Hildebrand, Jennifer A. Chan, Shan Liao, Michael J. Monument, Martin Hyrcza, Pinaki Bose, Craig N. Jenne, Johnathan Canton, Franz J. Zemp, Douglas J. Mahoney
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Oncolytic viruses (OV) are designed to selectively infect and kill cancer cells, while simultaneously eliciting antitumour immunity. The mechanism is expected to originate from infected cancer cells. However, recent reports of tumour regress
Externí odkaz:
https://doaj.org/article/e1b4ff19dd154ae59c5ddb76c77964d0
Autor:
Sicong Tu, Tiffany Li, Antonia S. Carroll, Colin J. Mahoney, William Huynh, Susanna B. Park, Robert Henderson, Steve Vucic, Matthew C. Kiernan, Cindy S-Y Lin
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Spinal and bulbar muscular atrophy (SBMA), or Kennedy’s disease (KD), is a rare hereditary neuromuscular disorder demonstrating commonalities with amyotrophic lateral sclerosis (ALS). The current study aimed to define functional and centra
Externí odkaz:
https://doaj.org/article/3a729a0a8aaa4b3e9eddf7e3187b6ec6
Autor:
Sahar Nasr, Lin Li, Mohammad Asad, Mahroo Moridi, Megan Wang, Franz J. Zemp, Douglas J. Mahoney, Edwin Wang
Publikováno v:
EBioMedicine, Vol 104, Iss , Pp 105167- (2024)
Summary: Background: Tumour-infiltrating lymphocytes (TILs) are crucial for effective immune checkpoint blockade (ICB) therapy in solid tumours. However, ∼70% of these tumours exhibit poor lymphocyte infiltration, rendering ICB therapies less effec
Externí odkaz:
https://doaj.org/article/177976b0157f46519e49a5171c255ca9
Autor:
Amir Pozner, Li Li, Shiv Prakash Verma, Shuxin Wang, Jared J. Barrott, Mary L. Nelson, Jamie S. E. Yu, Gian Luca Negri, Shane Colborne, Christopher S. Hughes, Ju-Fen Zhu, Sydney L. Lambert, Lara S. Carroll, Kyllie Smith-Fry, Michael G. Stewart, Sarmishta Kannan, Bodrie Jensen, Cini M. John, Saif Sikdar, Hongrui Liu, Ngoc Ha Dang, Jennifer Bourdage, Jinxiu Li, Jeffery M. Vahrenkamp, Katelyn L. Mortenson, John S. Groundland, Rosanna Wustrack, Donna L. Senger, Franz J. Zemp, Douglas J. Mahoney, Jason Gertz, Xiaoyang Zhang, Alexander J. Lazar, Martin Hirst, Gregg B. Morin, Torsten O. Nielsen, Peter S. Shen, Kevin B. Jones
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract The t(X,17) chromosomal translocation, generating the ASPSCR1::TFE3 fusion oncoprotein, is the singular genetic driver of alveolar soft part sarcoma (ASPS) and some Xp11-rearranged renal cell carcinomas (RCCs), frustrating efforts to identif
Externí odkaz:
https://doaj.org/article/22b004d19a254382bdb0a79d65c8bcf2
Autor:
Hayley M. Todesco, Chris Gafuik, Cini M. John, Erin L. Roberts, Breanna S. Borys, Alexis Pawluk, Michael S. Kallos, Kyle G. Potts, Douglas J. Mahoney
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101189- (2024)
The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic highlighted the importance of vaccine innovation in public health. Hundreds of vaccines built on numerous technology platforms have been rapidly developed against SARS-CoV-2 si
Externí odkaz:
https://doaj.org/article/fdb3ab36b00a41dab43e9dd75f45b765
A bioinformatics screen reveals hox and chromatin remodeling factors at the Drosophila histone locus
Autor:
Lauren J. Hodkinson, Connor Smith, H. Skye Comstra, Bukola A. Ajani, Eric H. Albanese, Kawsar Arsalan, Alvaro Perez Daisson, Katherine B. Forrest, Elijah H. Fox, Matthew R. Guerette, Samia Khan, Madeleine P. Koenig, Shivani Lam, Ava S. Lewandowski, Lauren J. Mahoney, Nasserallah Manai, JonCarlo Miglay, Blake A. Miller, Olivia Milloway, Nhi Ngo, Vu D. Ngo, Nicole F. Oey, Tanya A. Punjani, HaoMin SiMa, Hollis Zeng, Casey A. Schmidt, Leila E. Rieder
Publikováno v:
BMC Genomic Data, Vol 24, Iss 1, Pp 1-18 (2023)
Abstract Background Cells orchestrate histone biogenesis with strict temporal and quantitative control. To efficiently regulate histone biogenesis, the repetitive Drosophila melanogaster replication-dependent histone genes are arrayed and clustered a
Externí odkaz:
https://doaj.org/article/5b0e819b71584a1997530f7d6cd28354
Autor:
Ana Nikolic, Francesca Maule, Anna Bobyn, Katrina Ellestad, Seungil Paik, Sajid A. Marhon, Parinaz Mehdipour, Xueqing Lun, Huey-Miin Chen, Claire Mallard, Alexander J. Hay, Michael J. Johnston, Christopher J. Gafuik, Franz J. Zemp, Yaoqing Shen, Nicoletta Ninkovic, Katalin Osz, Elodie Labit, N. Daniel Berger, Duncan K. Brownsey, John J. Kelly, Jeff Biernaskie, Peter B. Dirks, Darren J. Derksen, Steven J. M. Jones, Donna L. Senger, Jennifer A. Chan, Douglas J. Mahoney, Daniel D. De Carvalho, Marco Gallo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Self-renewal is a crucial property of glioblastoma cells that is enabled by the choreographed functions of chromatin regulators and transcription factors. Identifying targetable epigenetic mechanisms of self-renewal could therefore represent
Externí odkaz:
https://doaj.org/article/028fa80da48448499589471060a20e19
Autor:
James J. Mahoney, Marc W. Haut, Jeffrey Carpenter, Manish Ranjan, Daisy G. Y. Thompson-Lake, Jennifer L. Marton, Wanhong Zheng, James H. Berry, Padma Tirumalai, Ashley Mears, Pierre D’Haese, Victor S. Finomore, Sally L. Hodder, Ali R. Rezai
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2023)
IntroductionWhile current treatments for substance use disorder (SUD) are beneficial, success rates remain low and treatment outcomes are complicated by co-occurring SUDs, many of which are without available medication treatments. Research involving
Externí odkaz:
https://doaj.org/article/65aadc344600486dba1085fa810dfbf4
Publikováno v:
GIScience & Remote Sensing, Vol 59, Iss 1, Pp 1266-1280 (2022)
Airborne LiDAR has become an essential data source for large-scale, high-resolution modeling of forest aboveground biomass and carbon stocks, enabling predictions with much higher resolution and accuracy than can be achieved using optical imagery alo
Externí odkaz:
https://doaj.org/article/42d7ffa2d5c04ea49bd9b36e1dacba2a
Autor:
Victor Naumenko, Jahanara Rajwani, Madison Turk, Chunfen Zhang, Mandy Tse, Rachelle P. Davis, Daesun Kim, Andrea Rakic, Himika Dastidar, Shinia Van, Laura K. Mah, Esha K. Kaul, Vladimir P. Chekhonin, Douglas J. Mahoney, Craig N. Jenne
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
A secondary (but not primary) dose of the oncolytic virus, VSV, is captured by monocytes and promotes CD8 + T cell recruitment, thereby revealing a mechanism underlying the clinical benefit of repeat dosing in oncolytic virus therapy.
Externí odkaz:
https://doaj.org/article/d1efee03275f465b9340ba163d0ab897