Zobrazeno 1 - 10
of 861
pro vyhledávání: '"J Magill"'
Autor:
Jeffrey Stedehouder, Bradley M. Roberts, Shinil Raina, Simon Bossi, Alan King Lun Liu, Natalie M. Doig, Kevin McGerty, Peter J. Magill, Laura Parkkinen, Stephanie J. Cragg
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Astrocytes are increasingly appreciated to possess underestimated and important roles in modulating neuronal circuits. Astrocytes in striatum can regulate dopamine transmission by governing the extracellular tone of axonal neuromodulators, i
Externí odkaz:
https://doaj.org/article/6aeb3ac2bdaf4b678bd9203fe41e062b
Publikováno v:
Neurobiology of Disease, Vol 201, Iss , Pp 106652- (2024)
Defining spatial synchronisation of pathological beta oscillations is important, given that many theories linking them to parkinsonian symptoms propose a reduction in the dimensionality of the coding space within and/or across cortico-basal ganglia s
Externí odkaz:
https://doaj.org/article/3493040dbaec47f6af013ec8f8b6a635
Autor:
Riccardo Avvisati, Anna-Kristin Kaufmann, Callum J. Young, Gabriella E. Portlock, Sophie Cancemi, Rui Ponte Costa, Peter J. Magill, Paul D. Dodson
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114080- (2024)
Summary: Midbrain dopamine neurons are thought to play key roles in learning by conveying the difference between expected and actual outcomes. Recent evidence suggests diversity in dopamine signaling, yet it remains poorly understood how heterogeneou
Externí odkaz:
https://doaj.org/article/756bc0140341414b838ae3a42e99d3de
Autor:
Damian J. Magill, Timofey A. Skvortsov
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-11 (2023)
Abstract Biofilm production plays a clinically significant role in the pathogenicity of many bacteria, limiting our ability to apply antimicrobial agents and contributing in particular to the pathogenesis of chronic infections. Bacteriophage depolyme
Externí odkaz:
https://doaj.org/article/f21524db3f7f41efb211699ff5209bde
Autor:
Christoph Wiest, Flavie Torrecillos, Alek Pogosyan, Manuel Bange, Muthuraman Muthuraman, Sergiu Groppa, Natasha Hulse, Harutomo Hasegawa, Keyoumars Ashkan, Fahd Baig, Francesca Morgante, Erlick A Pereira, Nicolas Mallet, Peter J Magill, Peter Brown, Andrew Sharott, Huiling Tan
Publikováno v:
eLife, Vol 12 (2023)
Periodic features of neural time-series data, such as local field potentials (LFPs), are often quantified using power spectra. While the aperiodic exponent of spectra is typically disregarded, it is nevertheless modulated in a physiologically relevan
Externí odkaz:
https://doaj.org/article/7387dc14ba204a988e5ed94e7914e603
Autor:
Bradley M. Roberts, Natalie M. Doig, Katherine R. Brimblecombe, Emanuel F. Lopes, Ruth E. Siddorn, Sarah Threlfell, Natalie Connor-Robson, Nora Bengoa-Vergniory, Nicholas Pasternack, Richard Wade-Martins, Peter J. Magill, Stephanie J. Cragg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
GABA transporters expressed in the striatum may affect behaviour. Here the authors investigate the contribution of GABA transporters on astrocytes to the regulation of dopamine release in the striatum, and show decreased expression of GAT-1 and GAT-3
Externí odkaz:
https://doaj.org/article/f4c24c167c97494e92ebdf24a5229496
Autor:
Timothy O West, Peter J Magill, Andrew Sharott, Vladimir Litvak, Simon F Farmer, Hayriye Cagnan
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 3, p e1009887 (2022)
Synchronization of neural oscillations is thought to facilitate communication in the brain. Neurodegenerative pathologies such as Parkinson's disease (PD) can result in synaptic reorganization of the motor circuit, leading to altered neuronal dynamic
Externí odkaz:
https://doaj.org/article/84c4474a19554467833683b450b75837
Autor:
Polina Kosillo, Natalie M. Doig, Kamran M. Ahmed, Alexander H.C.W. Agopyan-Miu, Corinna D. Wong, Lisa Conyers, Sarah Threlfell, Peter J. Magill, Helen S. Bateup
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Tuberous Sclerosis Complex (TSC) is a neurodevelopmental disorder caused by mutations in the TSC1 or TSC2 genes, which negatively regulate mTORC1 signalling. Here the authors selectively delete Tsc1 from dopamine neurons in mice and find impairments
Externí odkaz:
https://doaj.org/article/8f206497b65e4d93a92d89d476e37c28
Autor:
Koós T, Peter J. Magill, Daniela Calvigioni, Natalie M. Doig, Konstantinos Meletis, Krishnakanth Kondabolu, Ayeko O, Torres A, Bakhtawer Khan
The striatum and subthalamic nucleus (STN) are considered to be the primary input nuclei of the basal ganglia. Projection neurons of both striatum and STN can extensively interact with other basal ganglia nuclei, and there is growing anatomical evide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45061522a5848162a9522c317fc8f8e4
https://ora.ox.ac.uk/objects/uuid:44bf4707-cabc-465b-89ae-561289ef8b25
https://ora.ox.ac.uk/objects/uuid:44bf4707-cabc-465b-89ae-561289ef8b25
Autor:
Patrick J. Magill, Elizabeth Anderson, Elsa M. Cora, Sarah Bacus, Claire Watkins, Elizabeth Curcio, Joan F. Kroener, Francis P. Arena, Ian Rabinowitz, Melanie Royce, Aroop Mangalik, Vicente Valero, Massimo Cristofanilli
Purpose: This phase II randomized trial evaluated the efficacy and tolerability of anastrozole combined with gefitinib or anastrozole with placebo in women with hormone receptor–positive metastatic breast cancer (MBC).Experimental Design: Postmenop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04eef7a44323438f83c0b2e5c9a2110a
https://doi.org/10.1158/1078-0432.c.6517791
https://doi.org/10.1158/1078-0432.c.6517791