Zobrazeno 1 - 10 of 50 pro vyhledávání: '"J M Stadel"'
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Lysine 182 of Endothelin B Receptor Modulates Agonist Selectivity and Antagonist Affinity: Evidence for the Overlap of Peptide and Non-peptide Ligand Binding Sites
Autor: J A, Lee, J A, Brinkmann, E D, Longton, C E, Peishoff, M A, Lago, J D, Leber, R D, Cousins, A, Gao, J M, Stadel, C S, Kumar
Publikováno v: Biochemistry. 33:14543-14549
The potent vasoactive peptide hormone endothelin (ET) binds to receptors which belong to the G-protein coupled receptor family. The availability of non-peptide antagonists for ET receptors allows investigation of the relationship among the binding si
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fa4bfad310a4726df94931bd25c1e3c
https://doi.org/10.1021/bi00252a022
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3
Recombinant human secretory phospholipase A2: Purification and characterization of the enzyme for active site studies
Autor: L. Marshall, James E. Strickler, C. Jones, J. Kurdyla, A. Roshak, C. F. Bennett, Megan M. McLaughlin, George P. Livi, Keith Hoyle, S. Comer, D. A. Pfarr, J. M. Stadel
Publikováno v: Journal of Molecular Recognition. 5:145-153
A secreted form of phospholipase A2 (PLA2) is thought to play an important role in inflammatory diseases. To characterize this enzyme the cDNA encoding a low molecular weight PLA2 was cloned from a human placental cDNA library. The cDNA encoding the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c824ed52594a07a2d35834b9ae713c5
https://doi.org/10.1002/jmr.300050405
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4
Calcitonin gene-related peptide receptor independently stimulates 3',5'-cyclic adenosine monophosphate and Ca2+ signaling pathways
Autor: N, Aiyar, J, Disa, J M, Stadel, P G, Lysko
Publikováno v: Molecular and cellular biochemistry. 197(1-2)
Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse biological properties including potent vasodilating activity. Recently, we reported the cloning of complementary DNAs (cDNAs) encoding the human and porcine CGRP receptors which sh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0777718947202f393a9c7b7b449a3fd5
https://pubmed.ncbi.nlm.nih.gov/10485337
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5
Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP
Autor: D S, Woulfe, J M, Stadel
Publikováno v: The Journal of biological chemistry. 274(25)
GAIP is a regulator of G protein signaling (RGS) that accelerates the rate of GTP hydrolysis by some G protein alpha subunits. In the present studies, we have examined the structural basis for the ability of GAIP to discriminate among members of the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c6c85391f589cec72cdd693adbf321ee
https://pubmed.ncbi.nlm.nih.gov/10364213
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6
In vitro and in vivo characterization of intrinsic sympathomimetic activity in normal and heart failure rats
Autor: R N, Willette, N, Aiyar, T L, Yue, M P, Mitchell, J, Disa, B L, Storer, D P, Naselsky, J M, Stadel, E H, Ohlstein, R R, Ruffolo
Publikováno v: The Journal of pharmacology and experimental therapeutics. 289(1)
Clinical studies conducted with carvedilol suggest that beta-adrenoceptor antagonism is an effective therapeutic approach to the treatment of heart failure. However, many beta-adrenoceptor antagonists are weak partial agonists and possess significant
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::30edf1ed3b3479852cd2306c26bbe2aa
https://pubmed.ncbi.nlm.nih.gov/10086986
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8
Binding of [3H]-SKF 107260 and [3H]-SB 214857 to purified integrin alphaIIbbeta3: evidence for a common binding site for cyclic arginyl-glycinyl-aspartic acid peptides and nonpeptides
Autor: A, Wong, S M, Hwang, K, Johanson, J, Samanen, D, Bennett, S W, Landvatter, W, Chen, J R, Heys, F E, Ali, T W, Ku, W, Bondinell, A J, Nichols, D A, Powers, J M, Stadel
Publikováno v: The Journal of pharmacology and experimental therapeutics. 285(1)
The aggregation of activated platelets is mediated by the binding of fibrinogen to its cell surface receptor, the integrin alphaIIbbeta3. The recognition of fibrinogen by alphaIIbbeta3 depends, in part, on the tripeptide sequence Arg-Gly-Asp (RGD) in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::815fd085fc03796bfbb23f2e0a61be1e
https://pubmed.ncbi.nlm.nih.gov/9536015
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9
Chemokine receptors in human endothelial cells. Functional expression of CXCR4 and its transcriptional regulation by inflammatory cytokines
Autor: S K, Gupta, P G, Lysko, K, Pillarisetti, E, Ohlstein, J M, Stadel
Publikováno v: The Journal of biological chemistry. 273(7)
Chemokines play an important role in the regulation of endothelial cell (EC) function, including proliferation, migration and differentiation during angiogenesis, and re-endothelialization after injury. In this study, reverse transcriptase-polymerase
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::355e9b62182578b970ebe10c89255da5
https://pubmed.ncbi.nlm.nih.gov/9461627
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10
Studies on alpha v beta 3/ligand interactions using a [3H]SKF-107260 binding assay
Autor: A, Wong, S M, Hwang, P, McDevitt, D, McNulty, J M, Stadel, K, Johanson
Publikováno v: Molecular pharmacology. 50(3)
The vitronectin receptor (alpha v beta 3) is a member of the integrin superfamily that mediates cell attachment on arginine-glycine-aspartic acid (RGD)-containing adhesive proteins. A solid-phase microtiter assay was developed to investigate the bind
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b431636bc9abf553f9465734bdb5978c
https://pubmed.ncbi.nlm.nih.gov/8794891
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