Zobrazeno 1 - 10 of 25 pro vyhledávání: '"J M Ruppert"'
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Analysis of a Protein-Binding Domain of p53
Autor: Bruce Stillman, J. M. Ruppert
Publikováno v: Scopus-Elsevier
The tumor suppressor protein p53 was first isolated as a simian virus 40 large T antigen-associated protein and subsequently was found to function in cell proliferation control. Tumor-derived mutations in p53 occur predominantly in four evolutionaril
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d376c87ed7b86a0b9385e491a3afa3c
https://doi.org/10.1128/mcb.13.6.3811-3820.1993
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6
Scrambled exons
Autor: J M, Nigro, K R, Cho, E R, Fearon, S E, Kern, J M, Ruppert, J D, Oliner, K W, Kinzler, B, Vogelstein
Publikováno v: Cell. 64:607-613
Using a sensitive assay for RNA expression, we identified several abnormally spliced transcripts in which exons from a candidate tumor suppressor gene (DCC) were scrambled during the splicing process in vivo. Cloning and sequencing of PCR-amplified s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94dd8aa2114f25eac347d3953a5871f6
https://doi.org/10.1016/0092-8674(91)90244-s
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7
GLI3 Encodes a 190-Kilodalton Protein with Multiple Regions of GLI Similarity
Autor: Bert Vogelstein, J M Ruppert, K Arheden, Kenneth W. Kinzler
Publikováno v: Molecular and Cellular Biology. 10:5408-5415
The GLI oncogene, discovered by virtue of its amplification in human tumors, encodes a sequence-specific DNA-binding protein containing five zinc fingers. We have now characterized one member of a family of GLI-related zinc finger genes. A previously
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1883e588c7bf82d560bb71fe56af35e4
https://doi.org/10.1128/mcb.10.10.5408-5415.1990
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8
Gli1 acts through Snail and E-cadherin to promote nuclear signaling by β-catenin
Autor: Xingnan Li, Susan M. Lobo-Ruppert, W Deng, J M Ruppert
The Hedgehog pathway transcription factor Gli1 induces transformation of epithelial cells via induction of Snail, a repressor of E-cadherin (E-cad). E-cad is normally complexed with beta-catenin at the cell membrane. Loss of E-cad during developmenta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff11e4b0eaf3a1463be98d6eab090195
https://europepmc.org/articles/PMC2233601/
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9
Snail induction is an early response to Gli1 that determines the efficiency of epithelial transformation
Autor: Matthias H. Kraus, W Deng, Xingnan Li, J M Ruppert, Clinton D. Nail, Susan M. Lobo-Ruppert, Sarah K. Bailey
Gli family members mediate constitutive Hedgehog signaling in the common skin cancer, basal cell carcinoma (BCC). Snail/Snai1 is rapidly induced by Gli1 in vitro, and is coexpressed with Gli1 in human hair follicles and skin tumors. In the current st
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3481166fb192a860a52b17d89113868d
https://europepmc.org/articles/PMC1361531/
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10
Increase of GKLF messenger RNA and protein expression during progression of breast cancer
Autor: K W, Foster, A R, Frost, P, McKie-Bell, C Y, Lin, J A, Engler, W E, Grizzle, J M, Ruppert
Publikováno v: Cancer research. 60(22)
Genetic alterations found in carcinomas can alter specific regulatory pathways and provide a selective growth advantage by activation of transforming oncogenes. A subset of these genes, including wild-type alleles of GLI or c-MYC, and activated allel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c0315e3844a74f71e2e1595bea569f8a
https://pubmed.ncbi.nlm.nih.gov/11103818
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