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Proline oxidase, encoded by p53-induced gene-6, catalyzes the generation of proline-dependent reactive oxygen species

Autor: S P, Donald, X Y, Sun, C A, Hu, J, Yu, J M, Mei, D, Valle, J M, Phang

Publikováno v: Cancer research. 61(5)

The p53-dependent initiation of apoptosis is accompanied by the induction of proline oxidase (POX), a mitochondrial enzyme catalyzing the conversion of proline to pyrroline-5-carboxylate with the concomitant transfer of electrons to cytochrome c. How

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7c21c2f43d43b37e7c85e69745fa322d
https://pubmed.ncbi.nlm.nih.gov/11280728

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Differential formation of beta-catenin/lymphoid enhancer factor-1 DNA binding complex induced by nitric oxide in mouse colonic epithelial cells differing in adenomatous polyposis coli (Apc) genotype

Autor: J M, Mei, N G, Hord, D F, Winterstein, S P, Donald, J M, Phang

Publikováno v: Cancer research. 60(13)

Increased cytoplasmic beta-catenin levels and the associated nuclear beta-catenin/T-cell factor (Tcf)-lymphoid enhancer factor (LEF) complex formation have been frequently found in colon cancer. In this context, overproduction of nitric oxide (NO) at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a2d6a71a8bd3a505f5c519719f5e8a1f
https://pubmed.ncbi.nlm.nih.gov/10910042

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Differential expression and activity of phosphatases and protein kinases in adriamycin sensitive and resistant human breast cancer MCF-7 cells

Autor: G C Yeh, J M Phang, D Ratnasinghe

Publikováno v: International Journal of Oncology.

Multidrug resistance is one of the major obstacles in cancer chemotherapy. In tumor cells, overexpression of the transmembrane P-glycoprotein 170 (P-gp) is associated with the multidrug resistance phenotype and serves as a drug efflux pump. The activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e70b58dfabd6b7729672b78a90d8eff
https://doi.org/10.3892/ijo.13.1.79

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Increased UDP-glucuronosyltransferase activity and decreased prostate specific antigen production by biochanin A in prostate cancer cells

Autor: X Y, Sun, C A, Plouzek, J P, Henry, T T, Wang, J M, Phang

Publikováno v: Cancer research. 58(11)

Our laboratory has characterized androgen metabolism in an androgen-responsive prostate cancer cell line (LNCaP) and showed that these cells accumulated intracellular testosterone primarily as glucuronidated metabolites. Using a cell-free assay with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::150b044a8fa7842a8cc2be7f1abf01e7
https://pubmed.ncbi.nlm.nih.gov/9622078

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Prolidase activity in fibroblasts is regulated by interaction of extracellular matrix with cell surface integrin receptors

Autor: J A, Palka, J M, Phang

Publikováno v: Journal of cellular biochemistry. 67(2)

Prolidase (EC 3.4.13.9) is a ubiquitously distributed imidodipeptidase that catalyzes the hydrolysis of C-terminal proline or hydroxyproline containing dipeptides. The enzyme plays an important role in the recycling of proline for collagen synthesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::663f99d1a16e7517e199d38f80076fee
https://pubmed.ncbi.nlm.nih.gov/9328822

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Calorie restriction induces a p53-independent delay of spontaneous carcinogenesis in p53-deficient and wild-type mice

Autor: S D, Hursting, S N, Perkins, C C, Brown, D C, Haines, J M, Phang

Publikováno v: Cancer research. 57(14)

We reported previously that calorie restriction (CR) delays spontaneous carcinogenesis in p53-deficient (p53-/-) mice, suggesting that CR modulates carcinogenesis by p53-independent mechanisms. To further evaluate the role of p53, we monitored tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::55256a508a7db74b4cd9b9ded738f6b8
https://pubmed.ncbi.nlm.nih.gov/9230186

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Chemoprevention of spontaneous tumorigenesis in p53-knockout mice

Autor: S D, Hursting, S N, Perkins, D C, Haines, J M, Ward, J M, Phang

Publikováno v: Cancer research. 55(18)

Spontaneous tumorigenesis was evaluated in male p53-knockout (p53-/-) mice treated with dehydroepiandrosterone (DHEA), quercetin, d-limonene, or all-trans retinoic acid to determine whether tumor development in these mice can be modulated by cancer-c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::94a73fb493354b4b50e3e1b4e3b010af
https://pubmed.ncbi.nlm.nih.gov/7664260

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Effects of estrogen on apoptotic pathways in human breast cancer cell line MCF-7

Autor: T T, Wang, J M, Phang

Publikováno v: Cancer research. 55(12)

We utilized a reverse transcription-PCR method to examine the effect of estrogen on the expression of mRNA for Bcl-2 and Bax, two modulatory proteins in the apoptotic pathway, in human breast cancer cell line MCF-7. We found that the bcl-2 mRNA level

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fe12a9d3670676eb21ea0e71b983fb80
https://pubmed.ncbi.nlm.nih.gov/7780952

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Modulation of adriamycin accumulation and efflux by flavonoids in HCT-15 colon cells. Activation of P-glycoprotein as a putative mechanism

Autor: J W, Critchfield, C J, Welsh, J M, Phang, G C, Yeh

Publikováno v: Biochemical pharmacology. 48(7)

Since P-glycoprotein (P-gp) in normal tissues may serve as a cellular defense mechanism against naturally occurring xenobiotics, we considered whether physiologically active components of commonly ingested plant foods could influence P-gp function. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a4fe89967c7e94b3791aa42e3874cb03
https://pubmed.ncbi.nlm.nih.gov/7945444

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