Zobrazeno 1 - 10
of 78
pro vyhledávání: '"J M McIntosh"'
Autor:
Manju Karthikeyan, Jortan O. Tun, Kevin Chase, Lee S. Leavitt, Albebson L. Lim, Shrinivasan Raghuraman, Cheryl Dowell, Ronald W. Hughen, Alan R. Light, Baldomero M. Olivera, J. M. McIntosh, Jie Zhang, Noemi D. Paguigan, Eric W. Schmidt, Christopher A. Reilly, Zhenjian Lin, Cassandra E. Deering-Rice, Randall T. Peterson
In our efforts to discover new drugs to treat pain, we identified molleamines A-E (1-5) as major neuroactive components of the sea slug, Pleurobranchus forskalii and their prey, Didemnum molle tunicates. The chemical structures of molleamines were el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a93867834e3506529c91e592477639ba
https://doi.org/10.1101/2021.05.17.444536
https://doi.org/10.1101/2021.05.17.444536
Autor:
Alisa Agné, Anna I Chaveiro, Klaus-Dieter Schlüter, Matthias Hecker, Ivan Manzini, Sigrid Wilker, Andreas Hecker, Martin Reichert, Veronika Grau, Günther Schmalzing, J. M. McIntosh, Raymond Ogiemwonyi-Schaefer, Winfried Padberg, Anca-Laura Amati, Katrin Richter
Publikováno v:
The FASEB Journal. 35
Autor:
Sara Sanz-Lázaro, C. Gonzalez-Enguita, J. Medina-Polo, Amanda Jiménez-Pompa, Jesús Blázquez, J. M. McIntosh, Agustín Albillos
α7 nicotinic receptors have been involved in numerous pathologies. A hallmark of these receptors is their extremely fast desensitization, a process not fully understood yet. Here we show that human native α7 and α3β4 nicotinic receptors physicall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f794c4a4658605bcd98bc7bb4df272c2
https://doi.org/10.1101/2020.11.11.360537
https://doi.org/10.1101/2020.11.11.360537
Publikováno v:
Neuroscience. 295:187-197
l -Dopa-induced dyskinesias (LIDs) are a serious side effect of dopamine replacement therapy for Parkinson’s disease. The mechanisms that underlie LIDs are currently unclear. However, preclinical studies indicate that nicotinic acetylcholine recept
Autor:
Mara Dierssen, Rafael Maldonado, J. M. McIntosh, Susanna Molas, M. I. Damaj, H Anwar, Erika E. Perez, Michael F. Miles, Xiangning Chen, Pretal P. Muldoon, Uwe Maskos, N T Zaveri, M. De Biasi, B Rais, Kia J. Jackson, Jo Lynne Harenza
Publikováno v:
British Journal of Pharmacology. 171:3845-3857
Background and Purpose Recent data have indicated that α3β4* neuronal nicotinic (n) ACh receptors may play a role in morphine dependence. Here we investigated if nACh receptors modulate morphine physical withdrawal. Experimental Approaches To asses
Publikováno v:
Journal of Neuroscience
Journal of Neuroscience, Society for Neuroscience, 2012, 32 (7), pp.2352-6. ⟨10.1523/JNEUROSCI.4985-11.2012⟩
Journal of Neuroscience, 2012, 32 (7), pp.2352-6. ⟨10.1523/JNEUROSCI.4985-11.2012⟩
Journal of Neuroscience, Society for Neuroscience, 2012, 32 (7), pp.2352-6. ⟨10.1523/JNEUROSCI.4985-11.2012⟩
Journal of Neuroscience, 2012, 32 (7), pp.2352-6. ⟨10.1523/JNEUROSCI.4985-11.2012⟩
International audience; Polymorphisms in the gene for the α5 nicotinic acetylcholine receptor (nAChR) subunit are associated with vulnerability to nicotine addiction. However, the underlying normal functions of α5-containing nAChRs in the brain are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::728fac44377da5b414fdc504f9d76d19
https://ora.ox.ac.uk/objects/uuid:e6f02abe-b899-4add-a6a4-f6803a55d83b
https://ora.ox.ac.uk/objects/uuid:e6f02abe-b899-4add-a6a4-f6803a55d83b
Autor:
K. Richter, V. Mathes, M. Fronius, M. Althaus, A. Hecker, G. Krasteva-Christ, W. Padberg, A. J. Hone, J. M. McIntosh, A. Zakrzewicz, V. Grau
Publikováno v:
Scientific Reports
We demonstrated previously that phosphocholine and phosphocholine-modified macromolecules efficiently inhibit ATP-dependent release of interleukin-1β from human and murine monocytes by a mechanism involving nicotinic acetylcholine receptors (nAChR).
Autor:
J. M. McIntosh, Glen R. Hanson, Annette E. Fleckenstein, Michelle G. Baladi, Shannon M. Nielsen
Publikováno v:
Behavioural pharmacology. 27(5)
Preclinical studies have demonstrated that oral nicotine exposure attenuates long-term dopaminergic damage induced by toxins, including repeated, high doses of methamphetamine. It is suggested that alterations in nicotinic acetylcholine receptor (nAC
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 331:547-554
The alpha6 nicotinic acetylcholine receptor (nAChR) subunit is involved in nicotine-stimulated dopamine release in the striatum. It is expressed in brain regions and coexpressed with nAChR subtypes implicated in nicotine dependence behaviors; hence,
Autor:
Q. Cheng, Xin Wang, David Mendelowitz, Christopher Gorini, Olga Dergacheva, Heather Jameson, J. M. McIntosh, Harriet Kamendi
Publikováno v:
Journal of Neurophysiology. 101:1141-1150
Cardioinhibitory cardiac vagal neurons (CVNs) do not receive inspiratory-related excitatory inputs under normal conditions. However, excitatory purinergic and serotonergic pathways are recruited during inspiratory activity after episodes of hypoxia a