Výsledky vyhledávání - "J M Le Doussal"

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Comparison of the prognostic value of genomic grade index, Ki67 expression and mitotic activity index in early node-positive breast cancer patients

Autor: J. M. Le Doussal, Patrice Viens, Hélène Peyro-Saint-Paul, François Bertucci, Henri Roché, Frédérique Penault-Llorca, Anne-Laure Martin, Christos Sotiriou, Pascal Finetti, Daniel Birnbaum, Cécile Blanc-Fournier, Jocelyne Jacquemier, Laetitia Marisa, Magali Lacroix-Triki

Publikováno v: Annals of Oncology. 24:625-632

Background The genomic grade index (GGI) completes the prognostic value of histological grade (HG). Other proliferation markers include the mitotic activity index (MAI) and the Ki67 immunohistochemistry (IHC) status. We compared the prognostic value

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b15dda0f9e7e96b2cc349546a82b76
https://doi.org/10.1093/annonc/mds510

Zobrazit plný text záznamu

Enhanced in vivo targeting of an asymmetric bivalent hapten to double-antigen-positive mouse B cells with monoclonal antibody conjugate cocktails

Autor: J M Le Doussal, E Gautherot, M Martin, J Barbet, M Delaage

Publikováno v: The Journal of Immunology. 146:169-175

In order to target specifically double-Ag-positive cells in vivo, we synthesized chemically two mAb conjugates with specificities for both an allelic murine B cell-surface Ag and for a synthetic hapten. One conjugate was designed for its specificitie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc17eb76afef1f061e9742adf8d92d0f
https://doi.org/10.4049/jimmunol.146.1.169

Zobrazit plný text záznamu

Delivery of therapeutic doses of radioiodine using bispecific antibody-targeted bivalent haptens

Autor: E, Gautherot, J M, Le Doussal, J, Bouhou, C, Manetti, M, Martin, E, Rouvier, J, Barbet

Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 39(11)

Two-step pretargeting strategies have been designed to deliver radioisotopes to tumors more selectively than directly labeled antibodies or fragments. In this article, we compare quantitatively the potential of these strategies for the radioimmunothe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::46613a3309c8ab16099ff302bbb09f7f
https://pubmed.ncbi.nlm.nih.gov/9829586

Zobrazit plný text záznamu

Therapy for colon carcinoma xenografts with bispecific antibody-targeted, iodine-131-labeled bivalent hapten

Autor: E, Gautherot, J, Bouhou, J M, Le Doussal, C, Manetti, M, Martin, E, Rouvier, J, Barbet

Publikováno v: Cancer. 80

One of the main limitations of radioimmunotherapy (RIT) is the secondary toxicity related to the poor therapeutic indices achieved with labeled whole immunoglobulin (Ig)G or F(ab')2 fragments. To overcome this problem, we have developed a two-step ta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::50b645fcb0b56cd2440e9a160f3d1d54
https://pubmed.ncbi.nlm.nih.gov/9406716

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

'Peptabody': A new type of high avidity binding protein

Autor: Reto Crameri, J M Le Doussal, Alexey Terskikh, I Fisch, Jean-Pierre Mach, Andrey V. Kajava

A new type of high avidity binding molecule, termed “peptabody” was created by harnessing the effect of multivalent interaction. A short peptide ligand was fused via a semi-rigid hinge region with the coiled-coil assembly domain of the cartilage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47659ebb38703e69f2a84d7eac33097c
https://europepmc.org/articles/PMC19973/

Zobrazit plný text záznamu

Preliminary study of the metal binding site of an anti-DTPA-indium antibody by equilibrium binding immunoassays and immobilized metal ion affinity chromatography

Autor: J M Le Doussal, Valerie Boden, Jacques Barbet, Mookambeswaran A. Vijayalakshmi, Carole Colin

Publikováno v: Bioconjugate chemistry. 6(4)

Creating metal coordination sites by modifying an existing enzyme or by eliciting antibodies against metal chelate haptens is of great interest in biotechnology to create enzyme catalysts with novel specificities. Here, we investigate the metal bindi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df3194988b94c077515eac24147a909
https://pubmed.ncbi.nlm.nih.gov/7578356

Zobrazit plný text záznamu

Anti-idiotypic monoclonal antibody AB3, reacting with the primary antigen (CEA), can localize in human colon-carcinoma xenografts as efficiently as AB1

Autor: Jean-Pierre Mach, J Z de Moraes, José Daniel Lopes, J L Gesztesi, P. Westermann, J M Le Doussal

Publikováno v: International journal of cancer. 57(4)

BALB/c mice were immunized with anti-idiotypic monoclonal (MAb) antibody (anti-Id or Ab2) directed against an AB1 MAb anti-carcinoembryonic (CEA) in order to obtain AB3 MAbs (anti-anti-Id). AB3 MAbs were shown to recognise the primary antigen (CEA) a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c5ceaf7c5790b54212810a967bdc4cf
https://pubmed.ncbi.nlm.nih.gov/8181861

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání