Zobrazeno 1 - 10
of 26
pro vyhledávání: '"J M Grisar"'
Publikováno v:
European Journal of Pharmacology. 255:215-222
Oxygen-derived free radicals are involved in myocardial reperfusion injury. In the present study MDL 74,405 (S-(-)-3,4-dihydro-6-hydroxy-N,N,N-2,5,7,8-heptamethyl-2H-1-benzo pyran-2-ethanaminium 4-methylbenzenesulfonate), a hydrophilic derivative of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d91bf1373294a21fead8a4f183a380
https://doi.org/10.1016/0014-2999(94)90100-7
https://doi.org/10.1016/0014-2999(94)90100-7
Publikováno v:
ChemInform. 26
Analogues of alpha-tocopherol and ascorbic acid with permanently cationic substituents, i.e., phosphonium (8, 9), sulfonium (11), acylhydrazinium (13, 14), and ammonium (1, 16, 21), were synthesized, and the 2R and 2S enantiomers of the alpha-tocophe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28fae251f7017d99c2433a7ecccc2848
https://doi.org/10.1002/chin.199547286
https://doi.org/10.1002/chin.199547286
Autor:
E. R. Wagner, M. A. Petty, J. Dow, Joseph Wagner, J. M. Grisar, W. De Jong, K. D. Haegele, Frank Bolkenius
Publikováno v:
Journal of Medicinal Chemistry. 34:257-260
The alpha-tocopherol analogue 3,4-dihydro-6-hydroxy-N,N,N,2,5,7,8- heptamethyl-2H-1-benzopyran-2-ethanaminium 4-methylbenzenesulfonate (1a, MDL 73404) and its O-acetate 1b (MDL 74270) were synthesized. Compound 1a was found to be hydrophilic (log P =
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::549304761bc0ba92021f0f638f78db93
https://doi.org/10.1021/jm00105a040
https://doi.org/10.1021/jm00105a040
Publikováno v:
Journal of medicinal chemistry. 38(15)
Analogues of alpha-tocopherol and ascorbic acid with permanently cationic substituents, i.e., phosphonium (8, 9), sulfonium (11), acylhydrazinium (13, 14), and ammonium (1, 16, 21), were synthesized, and the 2R and 2S enantiomers of the alpha-tocophe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa57f1385ed1af44b5b765c6aed68ad0
https://pubmed.ncbi.nlm.nih.gov/7636848
https://pubmed.ncbi.nlm.nih.gov/7636848
Publikováno v:
Journal of medicinal chemistry. 38(3)
A series of alpha-tocopherol analogues was synthesized with potential therapeutic value for such pathological conditions as stroke and trauma. A set of criteria such as the inhibition of in vitro lipid peroxidation, superoxyl radical scavenging, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac1f8c8e24e045560e636a088a52a68b
https://pubmed.ncbi.nlm.nih.gov/7853338
https://pubmed.ncbi.nlm.nih.gov/7853338
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 19(6)
MDL74270 (6-acetyloxy-3,4-dihydro-N,N,N,2,5,7, 8-heptamethyl-2H-1-benzopyran-2-ethanaminium, 4-methylbenzenesulfonate) is a quaternary amine analogue of alpha-tocopherol with free radical scavenger properties. Rats were injected iv with [14C]MDL74270
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::87e51c4d5789ec61027061f9ae133c8c
https://pubmed.ncbi.nlm.nih.gov/1687008
https://pubmed.ncbi.nlm.nih.gov/1687008
Publikováno v:
European journal of pharmacology. 179(1-2)
A free radical scavenger can prevent the initiation, or terminate the propagation of free radical chain reactions such as lipid peroxidation. In view of the fast rate of these reactions and the short half-life of oxygen-derived free radicals, a scave
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec44092df82ad51aa56c27c5d36ea2e
https://pubmed.ncbi.nlm.nih.gov/2364988
https://pubmed.ncbi.nlm.nih.gov/2364988
Publikováno v:
Journal of Medicinal Chemistry. 17:721-725
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79f5ad8c3de16b464f9dac3610562055
https://doi.org/10.1021/jm00253a012
https://doi.org/10.1021/jm00253a012
Publikováno v:
Life Sciences. 27:2529-2534
Medroxalol is a new antihypertensive agent with combined α- and β-adrenergic receptor blocking properties. We have examined the antihypertensive and adrenergic receptor blocking properties of the enriched medroxalol enantiomers in the spontaneously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd7a612f1fd3aa50bf0b54a1755fe190
https://doi.org/10.1016/0024-3205(80)90534-2
https://doi.org/10.1016/0024-3205(80)90534-2
Publikováno v:
Journal of medicinal chemistry. 25(12)
A series of 4-aroyl-1,3-dihydro-2H-imidazol-2-ones was synthesized and evaluated for pharmacological activity in the anesthetized dog. Most members of this series produced dose-related increases in cardiac contractile force as well as relatively mino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9758103bb2ac5667913a239c81c72c39
https://pubmed.ncbi.nlm.nih.gov/7154009
https://pubmed.ncbi.nlm.nih.gov/7154009