Výsledky vyhledávání - "J M Glendening"

PTEN inactivation is rare in melanoma tumours but occurs frequently in melanoma cell lines

Autor: T Que Noy, Graeme J. Walker, N C Bloch, J M Glendening, Pamela M. Pollock, Jane W. Fountain, Nicholas K. Hayward

Publikováno v: Melanoma Research. 12:565-575

Deletions detected in cytogenetic and loss of heterozygosity (LOH) studies indicate that at least one tumour suppressor gene maps to the long arm of chromosome 10. Previous deletion mapping studies have observed LOH on 10q in about 30% of melanomas a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dd6db650cd48a0504626f8c4b3cfb67
https://doi.org/10.1097/00008390-200212000-00006

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Advanced glycation end products contribute to amyloidosis in Alzheimer disease

Autor: J. M. Glendening, Helen Vlassara, Keshab Bhattacharya, Michael P. Vitek, A. Cerami, Kirk R. Manogue, Richard Bucala, Edward G. Stopa

Publikováno v: Proceedings of the National Academy of Sciences. 91:4766-4770

Alzheimer disease (AD) is characterized by deposits of an aggregated 42-amino-acid beta-amyloid peptide (beta AP) in the brain and cerebrovasculature. After a concentration-dependent lag period during in vitro incubations, soluble preparations of syn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5ffab345c9e672a2ba94eb52c10f83
https://doi.org/10.1073/pnas.91.11.4766

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Virtually 100% of melanoma cell lines harbor alterations at the DNA level within CDKN2A, CDKN2B, or one of their downstream targets

Autor: G J, Walker, J F, Flores, J M, Glendening, A H, Lin, I D, Markl, J W, Fountain

Publikováno v: Genes, chromosomescancer. 22(2)

The cyclin-dependent kinase inhibitor 2A (CDKN2A), or p16INK4a, gene on 9p21 is important in the genesis of both familial and sporadic melanoma. Homozygous deletions and intragenic mutations of this gene have been identified in both melanoma cell lin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b97b5dab0bb5430828388de09f90e94b
https://pubmed.ncbi.nlm.nih.gov/9598804

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Low frequency of p16/CDKN2A methylation in sporadic melanoma: comparative approaches for methylation analysis of primary tumors

Autor: M L, Gonzalgo, C M, Bender, E H, You, J M, Glendening, J F, Flores, G J, Walker, N K, Hayward, P A, Jones, J W, Fountain

Publikováno v: Cancer research. 57(23)

Methylation of the 5' CpG island of the p16 tumor suppressor gene represents one possible mechanism for inactivation of this cell cycle regulatory gene that is also a melanoma predisposition locus. We have investigated the potential contribution of s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5157c6a6f8e57bb607de21d38207e8b1
https://pubmed.ncbi.nlm.nih.gov/9393758

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Loss of the p16INK4a and p15INK4b genes, as well as neighboring 9p21 markers, in sporadic melanoma

Autor: J F, Flores, G J, Walker, J M, Glendening, F G, Haluska, J S, Castresana, M P, Rubio, G C, Pastorfide, L A, Boyer, W H, Kao, M L, Bulyk, R L, Barnhill, N K, Hayward, D E, Housman, J W, Fountain

Publikováno v: Cancer research. 56(21)

Although homozygous deletions of the cyclin-dependent kinase inhibitor 2 gene p16INK4a on 9p21 have been reported frequently in metastatic melanoma cell lines, and intragenic mutations within the p16INK4a gene have been detected in familial melanoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5ad9faeedfba984b7f5ca56d41d686e3
https://pubmed.ncbi.nlm.nih.gov/8895759

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Artifactual strain-specific signs of incipient brain amyloidosis in APP transgenic mice

Autor: Patty Gonzalez-DeWhitt, David E. Lowery, H. G. Polites, Barry D. Greenberg, S. M. Ali, R. A. Altman, J. M. Glendening, Mary J. Savage, Sandra L. Siedlak, George Perry

Publikováno v: Neurobiology of aging. 17(2)

In an attempt to generate transgenic mice modeling Alzheimer-type amyloidogenesis, the COOH-terminal 103 residue human APP segment was expressed in brain regions known to be vulnerable in AD. Transfected cells overexpressing this transgene were previ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf669a533d0dd84002209b2fa77f455
https://pubmed.ncbi.nlm.nih.gov/8744403

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Mutations of the CDKN2/p16INK4 gene in Australian melanoma kindreds

Autor: Flores Jf, C J Hussussian, Frank G. Haluska, Jane W. Fountain, J M Glendening, Nicholas C. Dracopoli, Nicholas K. Hayward, Walker Gj

Publikováno v: Human molecular genetics. 4(10)

The cyclin dependent kinase inhibitor 2 (CDKN2) gene on chromosome 9p21 is potentially involved in the genesis of many cancers and is currently under intense investigation as a possible melanoma susceptibility locus. We have analyzed 18 Australian me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9924276c66678d1229b41be1f13c9e1d
https://pubmed.ncbi.nlm.nih.gov/8595405

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