Výsledky vyhledávání

Enhanced production of tissue inhibitor of metalloproteinases by peripheral blood mononuclear cells of rheumatoid arthritis patients responding to methotrexate treatment

Autor: M. Seitz, J.‐M. Dayer

Objective. To determine the effects of methotrexate (MTX ) treatment of rheumatoid arthritis (RA) patients (a) on the circulating levels and (b) on the ex vivo production of matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ccb09f749328b34b93cf5e49302037e
http://doc.rero.ch/record/292809/files/390637.pdf

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The pivotal role of interleukin-1 in the clinical manifestations of rheumatoid arthritis

Autor: J.-M. Dayer

Publikováno v: Rheumatology. 42:3ii-10

The role of the cytokine network in mediating inflammation and joint destruction in rheumatoid arthritis (RA) has been investigated extensively in recent years. Interleukin-1 (IL-1) and tumour necrosis factor alpha (TNFalpha) are two pivotal proinfla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d0bc238e318440e26dc1a5a399c911
https://doi.org/10.1093/rheumatology/keg326

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CD40-CD40 ligand (CD154) engagement is required but may not be sufficient for human T helper 1 cell induction of interleukin-2- or interleukin-15-driven, contact-dependent, interleukin-1β production by monocytes

Autor: C. Ribbens, C. Chizzolini, J.‐M. Dayer

Publikováno v: Immunology. 99:279-286

To investigate whether antigen-independent, interleukin-2 (IL-2) or IL-15 activation of polarized T helper (Th) cells would result in contact-dependent activation of monocytes, living Th1 and Th2 cell clones were co-cultured with THP-1 cells or fresh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb5927883e52b68e3eea17f9e4088c6b
https://doi.org/10.1046/j.1365-2567.2000.00948.x

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Allergen Immunotherapy: Therapeutic Vaccines for Allergic Diseases

Publikováno v: Annals of Allergy, Asthma & Immunology. 81:401-405

ABBREVIATIONS AAAAI: American Academy of Allergy, Asthma and Immunology AU: Allergy Unit BAU: Bioequivalent Allergy Unit BU: Biologic Unit CBER: Center for Biologic Evaluation and Research EAACI: European Academy of Allergy and Clinical Immunology EU

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85ae0e0e3e43e15220303c718dd6928c
https://doi.org/10.1016/s1081-1206(10)63136-5

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Superantigen-induced collagenase gene expression in human IFN-gamma-treated fibroblast-like synoviocytes involves prostaglandin E2. Evidence for a role of cyclooxygenase-2 and cytosolic phospholipase A2

Autor: K Mehindate, R al-Daccak, J M Dayer, B P Kennedy, C Kris, P Borgeat, P E Poubelle, W Mourad

Publikováno v: The Journal of Immunology. 155:3570-3577

MHC class II molecules expressed in lymphoid and nonlymphoid cells act as signal-transducer molecules. We demonstrate that engagement of MHC class II molecules on human IFN-gamma-treated fibroblast-like synoviocytes by their natural ligand, the staph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa2945241a4d4f0ada49e108e76db9eb
https://doi.org/10.4049/jimmunol.155.7.3570

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Immobilized anti-CD3 antibody activates T cell clones to induce the production of interstitial collagenase, but not tissue inhibitor of metalloproteinases, in monocytic THP-1 cells and dermal fibroblasts

Autor: A M Miltenburg, S Lacraz, H G Welgus, J M Dayer

Publikováno v: The Journal of Immunology. 154:2655-2667

In this study we have investigated whether direct cell to cell contact between activated paraformaldehyde-fixed T cell clones obtained from synovial tissue of patients with osteoarthritis (OA) or rheumatoid arthritis and target monocytic cells or der

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0cb15244443e3077de1bb8bc4d7d61da
https://doi.org/10.4049/jimmunol.154.6.2655

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Crystal-induced neutrophil activation. V. Differential production of biologically active IL-1 and IL-1 receptor antagonist

Autor: C J Roberge, R de Médicis, J M Dayer, M Rola-Pleszczynski, P H Naccache, P E Poubelle

Publikováno v: The Journal of Immunology. 152:5485-5494

Neutrophils produce IL-1 when stimulated by monosodium urate (MSU) or calcium pyrophosphate dihydrate (CPPD) crystals. Neutrophils also generate the IL-1R antagonist (IL-1Ra), especially when incubated with granulocyte-macrophage CSF (GM-CSF) or TNF-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ce769d205f4399c75c4cfccb2c2c630
https://doi.org/10.4049/jimmunol.152.11.5485

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