Zobrazeno 1 - 10
of 21
pro vyhledávání: '"J M Danforth"'
Autor:
J M Danforth, Theodore J. Standiford
Publikováno v:
Alcoholism: Clinical and Experimental Research. 21:1212-1217
The prolonged and excessive consumption of alcohol has been shown to predispose the host to a variety of infectious complications, which may be due, in part, to the inability to produce important activating and chemotactic cytokines. In this study, w
Autor:
Steven L. Kunkel, Theodore J. Standiford, Robert M. Strieter, Marc B. Bailie, J M Danforth, Lauri L. Laichalk
Publikováno v:
Infection and Immunity. 64:5211-5218
Tumor necrosis factor (TNF) is a proinflammatory cytokine which has recently been shown to have beneficial effects in the setting of acquired host immunity. However, the role of TNF in innate immune responses, as in the setting of bacterial pneumonia
Autor:
M J Greenberger, S L Kunkel, R M Strieter, N W Lukacs, J Bramson, J Gauldie, F L Graham, M Hitt, J M Danforth, T J Standiford
Publikováno v:
The Journal of Immunology. 157:3006-3012
IL-12 is a proinflammatory cytokine that has recently been shown to have beneficial effects in the setting of acquired host immunity. To determine the role of IL-12 in innate immunity against Gram-negative bacterial organisms, CBA/J mice were challen
Publikováno v:
FEMS Immunology & Medical Microbiology. 15:181-187
Effective host defense against bacterial invasion is characterized by the vigorous recruitment and activation of inflammatory cells, which is dependent upon the coordinated expression of both pro- and anti-inflammatory cytokines. Interleukin-10 (IL-1
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 13:399-409
Tissue injury that occurs as a result of ischemia and subsequent reperfusion is characterized by endothelial cell injury, edema formation, and the influx of inflammatory leukocytes. Two macrophage-derived proinflammatory cytokines which may play a cr
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 269:H980-H987
The production of cytokines directly from cardiac myocytes has not been previously demonstrated and could represent an important mechanism and site of intervention in ischemia and reperfusion injuries. Macrophage inflammatory protein-2 (MIP-2) and mo
Autor:
T J Standiford, S L Kunkel, N W Lukacs, M J Greenberger, J M Danforth, R G Kunkel, R M Strieter
Publikováno v:
The Journal of Immunology. 155:1515-1524
Systemic exposure to LPS initiates a complex sequence of events resulting in organ-specific leukocyte recruitment and end-organ injury. We hypothesized that macrophage inflammatory protein-1 alpha (MIP-1 alpha), a C-C chemokine with leukocyte chemota
Publikováno v:
The Journal of Immunology. 155:722-729
Effective host defense against bacterial infection is dependent upon the vigorous recruitment and activation of neutrophils and macrophages. We hypothesized that IL-10 is produced in the setting of bacterial pneumonia, and this cytokine may attenuate
Autor:
G M VanOtteren, R M Strieter, S L Kunkel, R Paine, M J Greenberger, J M Danforth, M D Burdick, T J Standiford
Publikováno v:
The Journal of Immunology. 154:1900-1908
Systemic exposure to LPS initiates a complex sequence of events culminating in organ-specific leukocyte recruitment and end organ injury. We hypothesized that RANTES, a C-C chemokine with potent M phi (mononuclear phagocyte) chemotactic activity, is
Autor:
T J, Standiford, J M, Danforth
Publikováno v:
Alcoholism, clinical and experimental research. 21(7)
The prolonged and excessive consumption of alcohol has been shown to predispose the host to a variety of infectious complications, which may be due, in part, to the inability to produce important activating and chemotactic cytokines. In this study, w